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Hello, ladies and gents Roberts 
like sceeto Savage.com. 

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And today I've got special guest
dr. 

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Stephen gun drawn, the line. 
He is known for his book, The 

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Plant Paradox, he's got, he's 
got several books, he's got a 

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new one, coming out to this 
March unlocking, the keto code, 

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and we dive into all kinds of 
things. 

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We talked about lectins, we 
talked about uncoupling, 

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mitochondria, we talked about 
all kinds of things, enjoy the 

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conversation, not going to lie, 
I'm not sure that I agree with 

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him on everything. 
We, I definitely did not agree 

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with him on everything that we 
talked about, but that's Of the 

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beauty of the conversation, I 
intentionally bring people on to

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the podcast that I have 
differing opinions on so that I 

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can pick their brain, see where 
they're, when they're staying on

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certain things, understand why 
they stand on certain things. 

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I just dive deeper and learn 
more. 

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That's how we can all grow and 
get better and improve our 

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health and nutrition and 
optimize our lives. 

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So I learned a lot, I'm going to
be diving deeper into some of 

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the research articles. 
He mentions in the podcast, 

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highly encourage you all to do 
the same but yeah. 

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I think you'll I think you'll 
take something from this podcast

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without a Doubt. 
So that for their do. 

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Sit back, relax. 
Enjoy the conversation with dr. 

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Steven gundry 
And we are live doctor gundry. 

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How are you, sir? 
Very good. 

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Thanks for having me. 
I'm excited to have you get a 

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lot of things and work for now. 
You've got a book coming out in 

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March. 
I definitely want to dive into 

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that. 
But I feel like we got a touch a

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little bit on your first great 
successful book The Plant 

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Paradox if like that's where a 
lot of people in the keto low 

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carb space have probably heard 
of you and familiarize himself 

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with your work. 
So, can you Before you can dive 

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into that. 
Can you kind of give that 

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listeners a little context and 
background as to what got you 

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into the health and nutrition 
space in the first place? 

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Yeah. 
Yeah. 

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I was a professor and chairman 
of cardiothoracic surgery at 

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Loma Linda University and very 
famous for doing baby heart 

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transplants and doing a lot of 
redo operations on adults and I 

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would be asked to take On 
patients that nobody really want

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to take on. 
There are a few of us idiots 

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that would kind of volunteer for
hazardous duty. 

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If a patient wanted to try and 
about truth 25 years ago now, a 

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gentleman by the who I call Big 
Ed from Miami 48 year old 

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gentleman was referred to me 
with inoperable coronary artery 

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disease. 
That means Literally all of his 

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blood vessels were clogged up, 
you couldn't put stents in them,

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you couldn't do bypasses because
there wasn't any place to do a 

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bypass, and he'd been going 
around the country, looking for 

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a center to take him on. 
And he spent about six months 

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doing this, and everybody who 
saw him turned him down, and he 

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ended up in my office after 
about six months, and I looked 

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at the angiogram, the movie of 
his Coronary artery vessels that

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from six months earlier and I 
said, you know, I agree with 

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everybody else. 
There's nothing I can do for 

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you, I'm sorry there's just 
nothing there and he said well 

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yeah but look I've it's been six
months, I've been on a diet, I 

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lost 45 pounds this, he was 265 
pounds when I met him and he 

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says I've gone to a health food 
store. 

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I'm taking lots of supplements 
and he literally brought in this

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big shopping bag full of 
supplements. 

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He said, you know, maybe I did 
something to my heart and I go, 

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wow, you know, good for you for 
losing weight but that's really 

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not going to help what we have 
to do. 

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And and I know what you did with
those supplements, you made 

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expensive urine, which I firmly 
believed back then. 

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And he said, well, what the 
heck? 

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I've come all this way, why 
can't we get another angiogram? 

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Why can't we do a cardiac 
catheterization? 

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So we did and this guy in six 
months time a cleaned out 50% of

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the blockages in his coronary 
arteries and six months 

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literally gone. 
And I had never seen anything 

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like that. 
And I said, you know, tell me 

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about this diet ears and let me 
look at those supplements. 

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Well I had a special major back 
in the Dark Ages as an 

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undergraduate at Yale 
University, where I had a thesis

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that you could take a grade-a 
manipulated, A food supply, 

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manipulate its environment, 
prove you arrived in a human 

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being and I got an honors for my
thesis and gave it to my parents

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and one out to be a famous heart
surgeon. 

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So big and starts telling me 
about the diet he was on, right?

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I stopped and I said, wait a 
minute. 

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That's the diet that I described
made us human. 

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And what's in your bag is 
supplements. 

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So I started looking in his bag 
of supplements and I was famous 

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for keeping Hearts Alive for 48 
hours and a bucket of ice water 

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for heart transplant and we put 
various Solutions and stuff down

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the arteries and veins of the 
heart to do this and lo and 

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behold he was swallowing some of
the stuff I was Putting down the

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veins and arteries and never 
occurred to me to swallow these 

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things. 
So, long story short, I was a 

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big fat guy even though I was 
running 30 miles a week going 

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the gym one hour every day, 
eating healthy, low-fat, mostly 

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vegetarian diet and couldn't 
figure out why. 

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I was such a big fat guy. 
So long story short, I put 

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myself on my thesis from college
and started taking a bunch of 

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supplements and the first year I
lost 50 pounds so I'm just going

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lost another 20 and I kept it 
off for 25 years now. 

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So I started teaching my 
patients that I operated on this

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program and they are high blood 
pressure went away, their 

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diabetes went away or their 
arthritis, went away. 

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And after about a year of this 
at Loma Linda, I had the stupid 

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idea, one Friday that I was 
doing this all wrong, I 

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shouldn't operate on people 
first and then teach them how to

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eat. 
I should teach them how to eat, 

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and then I wouldn't have to 
operate on them for a heart 

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surgeon. 
That's a really bad career 

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choice. 
The left liquid about it, but I 

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get, yeah, I quit my position 
and set up a clinic here in Palm

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Springs, California. 
And now we have one in Santa 

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Barbara to and I actually 
approached it as a research 

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project and I asked people to 
avoid certain foods, primarily 

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and go to Costco or Trader. 
Joe's or wasn't an Amazon back 

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then in by some supplements. 
And every, every three months we

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track their blood work that 
insurance or Medicare would pay 

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for and we could see and do 
Document. 

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And I started publishing what 
was happening with these people.

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And after about 15 years of 
this, that resulted in the plant

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Paradox, which is now five years
old, this this April and That 

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Shook things up, in in the 
nutrition World, subsequently 

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we've had seven books in the 
series, the most recent one, See

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how you like you mentioned in 
March unlocking the keto code 

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and there you go. 
Definitely dive into a few areas

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here with regard to the diet 
that big Ed was eaten and you 

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were thesis paper. 
What did that look like? 

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Like if you were to describe 
that diets what does that 

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consist of? 
Well, most people probably in 

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the keto community and know that
no human being being a to grain 

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or a bean until about 10,000 
years ago, they did not exist as

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a food. 
What a lot of people don't know 

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is that all of us are originally
from Africa, Asia or Europe and 

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it wasn't until 500 years ago 
when Columbus started Colombian 

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trade of new world. 
Products and foods that were 

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completely foreign to all human 
beings, most human beings until 

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500 years ago, and that includes
the nightshade family. 

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Like tomatoes like eggplant like
peppers. 

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Like potatoes includes corn and 
quinoa includes most of the 

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squash family and all of these 
different grains. 

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Different American Products, 
all, we're brand new foods, and 

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all of them in one way or 
another. 

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Had plant proteins that plants 
use as their fence against being

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eaten. 
One of which got my attention, 

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which is a lectins, and we, in 
the program, remove most lectin 

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containing foods from people's 
diets. 

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And if we can't remove them, we 
defuse them. 

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We typed detoxify them. 
If you will. 

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I got you, I got you a lot of 
people especially they're 

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following a standard, American 
diets are so out of touch with 

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their body and how they feel 
based off the nutrition. 

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They're consuming that they 
don't even know what they're 

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looking for half the time. 
So if someone is not optimized 

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so to speak and it may be a 
result of too much lectin 

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consumption. 
What are some you know 

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phenotypical things that they're
probably experiencing? 

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Well you know, Hippocrates 2500 
years ago, said all disease 

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begins in the gut and he was 
absolutely right. 

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I've paraphrased him as well as 
dr. 

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Alessio Fasano, who's now at 
Harvard? 

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We say that all disease begins 
with a leaky gut and I have 

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published a lot, he's published 
a lot that in fact, if You have 

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a disease. 
I can virtually guarantee you, 

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you have leaky gut, if you have 
an autoimmune disease, 

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psoriasis, rheumatoid, 
arthritis, lupus Hashimoto's 

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thyroiditis, I can guarantee 
you, you have leaky gut and the 

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good news is when we seal leaky 
gut, All of these problems go 

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away. 
I used to have horrible migraine

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headaches for example and he's 
do baby heart transplants with 

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migraines. 
I don't recommend it and those 

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went away 25 years ago and have 
never come back. 

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My used to have horrible, 
heartburn used to travel around 

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with Tom's. 
Heartburn is actually caused by 

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lectins and once I stopped 
eating them and months. 

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My patient stop eating them, 
their heartburn goes away. 

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There's there's more and more 
work, that depression and 

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anxiety, and many things that we
call. 

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Mental. 
Health issues are actually 

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probably gut health issues first
that then affects the brain. 

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So Epocrates was right all 
disease begins in the gut and 

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good news is all Is can end in 
the gut. 

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So what's happening like from a 
minute mechanistic standpoint 

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with these elections in the guy 
doesn't like I just inflamed 

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flama, Tory response, it's 
happening there. 

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Yeah, it's actually better than 
that dr. 

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Fasano proved, that lectins and 
gluten, and it happens to be a 

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lectin can bind to the surface 
of the wall of our gut, which is

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literally the same surface area 
as a tennis court. 

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Art. 
And that surface is only one 

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cell thick, we've got kind of a 
design flaw and these cells are 

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all held together. 
Locked arms, like the kids game 

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Red Rover, Red Rover and lectins
can bind to the wall of the gut,

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and they literally can flip a 
switch and make a compound. 

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Called zanya learn which can 
break these tight junctions. 

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And so you then have literal 
gaps between these cells that 

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line the gut. 
And so not only can lectins get 

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through these gaps. 
And electrons are proteins, but 

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they're foreign proteins and our
immune system, 80% of all our 

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white blood cells line, our got 
80% and that's because This is 

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actually where trouble can come 
through first. 

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So lectins can get through, the 
immune system, sees them as a 

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foreign particle and they 
literally start attacking these 

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particles and it's that Warfare 
if you will, that is 

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inflammation. 
Not only that but pieces of 

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bacteria and whole bacteria can 
leak through The wall of the 

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gut. 
And quite frankly, they're not 

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supposed to be on the other side
of the gut and our immune system

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goes after them and lastly, 
what's even more? 

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Fascinating is normally the food
we eat is digested into sugar 

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molecules amino acids from 
proteins, and fatty acids from 

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fats and then absorbed through 
the wall of our gut. 

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00:14:48,800 --> 00:14:54,900
But if we actually have spaces 
between these cells, Then 

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undigested food particles of 
perfectly, normal food. 

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00:15:00,300 --> 00:15:05,700
Let's just use an example like a
piece of broccoli could get 

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across the wall of our gut and 
your immune system sees this guy

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piece of broccoli. 
And so what the heck? 

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00:15:12,000 --> 00:15:16,000
I have never seen a piece of 
broccoli before in my life that 

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is foreign. 
And I'm going to attack it. 

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So we now and we can measure 
these things now. 

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And so we can now I actually 
identify the sort of foods that 

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are actually causing the problem
in the great thing is, once you 

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00:15:35,800 --> 00:15:41,500
remove these troublemakers, the 
got literally can heal itself. 

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It can take up to a year to do 
it, but once it's healed. 

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Then people can read tolerate, a
lot of foods that were actually 

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00:15:52,700 --> 00:15:54,800
troublemakers for them when they
first come. 

226
00:15:54,800 --> 00:15:57,700
See me and have all the 
Troublemaker foods that are 

227
00:15:57,700 --> 00:16:01,000
speak lectins are kind of one of
the top of the totem pole. 

228
00:16:01,700 --> 00:16:05,100
Yeah, yeah. 
It's it's amazing. 

229
00:16:05,500 --> 00:16:09,700
You know when people read the 
plant Paradox whom have never 

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00:16:09,700 --> 00:16:14,200
met me and then I'll you know 
I'll get a email from them or 

231
00:16:14,200 --> 00:16:18,900
they'll write to our podcast, 
the doctor Andre podcast that, 

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00:16:18,900 --> 00:16:22,500
you know, son of a gun, you 
know, I, you know, you saved my 

233
00:16:22,500 --> 00:16:25,200
life. 
I took these Foods away that I 

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00:16:25,200 --> 00:16:30,000
thought were, I was told were 
really good for me and Son of a 

235
00:16:30,008 --> 00:16:35,300
god, they, they were the cause 
of my depression or they were to

236
00:16:35,300 --> 00:16:39,800
the cause of my arthritis or 
they were the cause of my 

237
00:16:39,800 --> 00:16:43,000
coronary artery disease, like 
Big Ed's example. 

238
00:16:43,800 --> 00:16:46,100
And you can resolve these 
things. 

239
00:16:46,100 --> 00:16:50,900
That's what's exciting. 
So when you remove all the foods

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00:16:50,900 --> 00:16:54,200
that contain lectins from your 
diet, what does that leave you 

241
00:16:54,200 --> 00:16:55,600
with from a vegetation 
standpoint? 

242
00:16:55,600 --> 00:16:57,200
Like do you eat a lot of 
vegetables? 

243
00:16:57,200 --> 00:17:03,600
Personally, yes, indeed. 
I am a plant predator and anyone

244
00:17:03,600 --> 00:17:09,000
who's been with me knows that I 
eat a lot of plants. 

245
00:17:09,000 --> 00:17:17,800
Mainly leaves nuts, a Consume 
ton of olive oil but all of the 

246
00:17:17,800 --> 00:17:22,300
all the leaves a lot of lot of 
you know. 

247
00:17:22,300 --> 00:17:28,300
For instance an avocado is a 
fruit but it's a great fruit. 

248
00:17:28,300 --> 00:17:32,100
Artichokes are a phenomenal 
food. 

249
00:17:32,100 --> 00:17:37,400
The Chicory family. 
Many people have heard of 

250
00:17:37,400 --> 00:17:43,400
Radicchio or seen this kind of 
red ball of Italian. 

251
00:17:43,700 --> 00:17:48,400
Let us is not lettuce in the 
grocery store and these things 

252
00:17:48,400 --> 00:17:53,000
actually not only are great for 
you but they actually feed 

253
00:17:53,200 --> 00:17:57,700
friendly bacteria in our gut. 
You know, my last few books have

254
00:17:57,700 --> 00:18:03,700
been really devoted to the care 
and feeding of the of 

255
00:18:03,700 --> 00:18:11,000
microbiome, the gut buddies as I
call them and getting rid of the

256
00:18:11,000 --> 00:18:13,900
bad bugs in our gut. 
The gang members, And 

257
00:18:14,000 --> 00:18:21,600
interestingly enough, we now 
know that the types of bacteria 

258
00:18:21,600 --> 00:18:27,800
in your gut have different 
desires for different foods and 

259
00:18:28,400 --> 00:18:35,800
the gang members actually love 
simple carbohydrates and fats 

260
00:18:35,800 --> 00:18:41,400
saturated fats. 
And these they actually send 

261
00:18:41,700 --> 00:18:46,900
text messages to your brain. 
Brain to get more of these form 

262
00:18:46,900 --> 00:18:50,200
themselves. 
On the other hand, the gut 

263
00:18:50,200 --> 00:18:53,700
buddies. 
Can't use those Foods on the 

264
00:18:53,700 --> 00:18:58,800
other they want soluble fibers. 
Like are some of the foods. 

265
00:18:58,800 --> 00:19:02,800
I was just talking about and 
there's actually some really 

266
00:19:02,900 --> 00:19:07,700
cool human data not to mention 
animal data that you can take 

267
00:19:09,500 --> 00:19:15,600
bacteria from an obese human. 
And do a fecal transplant to a 

268
00:19:15,600 --> 00:19:21,600
skinny human and that skinny 
human will become obese strictly

269
00:19:21,600 --> 00:19:28,500
because the bacteria took over 
their willpower is a nice way to

270
00:19:28,500 --> 00:19:31,700
say it. 
So they isn't lending them to 

271
00:19:31,700 --> 00:19:34,200
just over consume calories in 
general. 

272
00:19:34,200 --> 00:19:35,600
Or is there something on a 
deeper level? 

273
00:19:35,600 --> 00:19:38,200
They're great. 
Question two things they 

274
00:19:38,200 --> 00:19:44,100
actually make you seek out 
high-calorie foods high sugar 

275
00:19:44,100 --> 00:19:49,400
foods, high fat foods. 
But as I showed in the energy 

276
00:19:49,400 --> 00:19:55,300
Paradox, my last book, these 
bacteria are actually very 

277
00:19:55,300 --> 00:20:02,700
efficient at extracting more 
More calories out of the food, 

278
00:20:02,700 --> 00:20:08,500
you eat and literally processing
it for you. 

279
00:20:09,300 --> 00:20:15,600
On the other hand, the good 
bacteria, actually keep most of 

280
00:20:15,600 --> 00:20:19,100
the calories that you eat as 
long as they're the right ones 

281
00:20:19,100 --> 00:20:24,300
for themselves to make more of 
themselves. 

282
00:20:24,300 --> 00:20:31,400
So the surprising thing is I've 
never had a calorie In any of my

283
00:20:31,400 --> 00:20:33,700
books. 
I've never had a macro in any of

284
00:20:33,700 --> 00:20:39,000
my books we just tell people. 
Okay, here's here's the foods 

285
00:20:39,000 --> 00:20:40,700
you want to avoid. 
Here's the food. 

286
00:20:40,700 --> 00:20:44,700
You want to eat and eat as much 
as you want of them. 

287
00:20:45,000 --> 00:20:50,200
And people are shocked that 
they're eating a lot of food. 

288
00:20:50,500 --> 00:20:54,000
And for the most part, losing 
weight and that actually 

289
00:20:54,000 --> 00:20:58,600
prompted the latest book. 
I definitely want to dive into 

290
00:20:58,600 --> 00:21:00,900
that before. 
Oh, that when it comes to like 

291
00:21:01,200 --> 00:21:03,500
carnivore diets, for instance, 
like carnivores gained a lot of 

292
00:21:03,508 --> 00:21:06,700
momentum and people seem to have
a tremendous success with that, 

293
00:21:06,700 --> 00:21:10,000
is that in your opinion, mostly 
results at the complete removal 

294
00:21:10,000 --> 00:21:13,400
of lectins or do you think 
they're missing out by not 

295
00:21:13,400 --> 00:21:15,000
incorporating vegetables back 
in? 

296
00:21:16,500 --> 00:21:21,900
Well, I yeah, I some people have
called me the, in an inadvertent

297
00:21:21,900 --> 00:21:26,800
father of the carnivore diet 
because a carnivore diet in 

298
00:21:26,800 --> 00:21:30,400
general eliminates most lectin 
containing foods. 

299
00:21:31,800 --> 00:21:37,500
There's a few exceptions to 
that, but I don't mind a 

300
00:21:37,600 --> 00:21:42,200
carnivore diet as an Elimination
Diet, but as I've written about 

301
00:21:42,200 --> 00:21:46,100
in all my books, there are some 
some real long. 

302
00:21:46,300 --> 00:21:52,500
Term. 
Even short-term disturbing 

303
00:21:53,000 --> 00:22:01,800
effects of a carnivore diet and 
just to name one beef lamb and 

304
00:22:01,800 --> 00:22:13,000
pork have a sugar molecules 
called neu5gc and four. 

305
00:22:13,000 --> 00:22:22,000
People want to remember to say 
who knew And it's in eu5 GC, our

306
00:22:22,000 --> 00:22:26,100
blood vessels, on the other 
hand, have a sugar molecule 

307
00:22:26,500 --> 00:22:31,700
called, new 5ac. 
We share that Sugar molecule 

308
00:22:31,700 --> 00:22:39,300
with fish and poultry. 
So interestingly enough these 

309
00:22:39,300 --> 00:22:47,000
molecules are very similar. 
And we can actually make and 

310
00:22:47,100 --> 00:22:54,100
auto antibody to our sugar 
molecule lining, our gut and 

311
00:22:54,100 --> 00:22:58,500
lining, our blood vessels and 
attack our blood vessels. 

312
00:22:58,500 --> 00:23:05,500
When we eat beef lamb or pork 
and that may be one of the 

313
00:23:05,500 --> 00:23:11,600
reasons why eating red meat 
Associates with coronary 

314
00:23:11,600 --> 00:23:14,000
arteries, It's that to one 
possibility. 

315
00:23:14,600 --> 00:23:18,200
The other thing we know is that 
cancer cells. 

316
00:23:18,800 --> 00:23:28,300
Tumors use neu5gc to cloak 
themselves and hide from the 

317
00:23:28,300 --> 00:23:31,500
immune system and this has been 
known for years. 

318
00:23:32,200 --> 00:23:38,100
The only problem is, we don't 
manufacture neu5gc, we only 

319
00:23:38,100 --> 00:23:44,000
manufacture new 5ac. 
So The cancer cells have to 

320
00:23:44,000 --> 00:23:53,700
acquire neu5gc via US eating 
beef, lamb or pork and that may 

321
00:23:53,700 --> 00:24:00,200
account for why red meat eaters 
have a higher incidence of 

322
00:24:00,200 --> 00:24:04,600
cancer. 
So those are I think that's a 

323
00:24:05,900 --> 00:24:10,100
that's that's enough of a worry.
The second worry that I write 

324
00:24:10,100 --> 00:24:15,300
about in the book so that's been
discovered by the Cleveland 

325
00:24:15,300 --> 00:24:21,500
Clinic for many years now is 
that animal proteins and fats 

326
00:24:22,400 --> 00:24:28,000
are converted in by our 
intestinal bacteria into a 

327
00:24:28,000 --> 00:24:36,100
compound called tmao. 
And tmao is a pretty Nasty, 

328
00:24:36,100 --> 00:24:38,300
compound, that damages blood 
vessels. 

329
00:24:38,900 --> 00:24:43,200
It's recently been associated 
with dementia and Parkinson's. 

330
00:24:43,800 --> 00:24:51,300
It's been associated with kidney
damage and it does not occur in 

331
00:24:51,300 --> 00:25:00,000
vegans, it only occurs in meat 
eaters, and We can measure that 

332
00:25:00,000 --> 00:25:04,800
we measure routinely in our 
patients and it's fascinating to

333
00:25:04,800 --> 00:25:13,500
them if we ask them to just for 
two weeks, give up animal 

334
00:25:13,500 --> 00:25:17,500
products, and we measure tmao 
before and after, and they're 

335
00:25:17,500 --> 00:25:20,300
shocked that the tmao 
disappears. 

336
00:25:20,400 --> 00:25:25,300
Once they do that, and they're 
shocked when it reappears, after

337
00:25:25,300 --> 00:25:28,500
they go back and start eating, 
even something as simple. 

338
00:25:28,600 --> 00:25:33,500
Is a couple of bags. 
So those are to me, particularly

339
00:25:34,100 --> 00:25:36,000
as art, surgeons and 
cardiologists. 

340
00:25:36,000 --> 00:25:41,700
Pretty compelling reasons that 
long-term a carnivore diet. 

341
00:25:41,800 --> 00:25:49,800
Probably isn't a very good idea.
Also, since I study longevity 

342
00:25:49,800 --> 00:25:58,500
and long living humans, there is
not a human tribe culture that 

343
00:25:58,700 --> 00:26:04,000
Is heavily meet Laden that has 
longevity. 

344
00:26:04,500 --> 00:26:08,800
There's there isn't one and you 
would think if this was such a 

345
00:26:08,808 --> 00:26:13,400
good idea that some culture 
would have thrived doing this 

346
00:26:13,400 --> 00:26:15,800
and they unfortunately known 
exist. 

347
00:26:16,400 --> 00:26:21,300
Now a lot of the studies that 
cast meet in a negative light 

348
00:26:21,300 --> 00:26:23,000
with regard to cancer research 
and whatnot. 

349
00:26:23,400 --> 00:26:26,700
Those are often times in the 
context of a population size of 

350
00:26:26,700 --> 00:26:29,100
that's also consuming a lot of 
hydrate, right? 

351
00:26:29,100 --> 00:26:33,000
And there's not really been 
studied, then looking at meet 

352
00:26:33,000 --> 00:26:35,800
and obeys consumption 
independent of a high 

353
00:26:35,800 --> 00:26:38,100
carbohydrate or higher 
carbohydrate diet as well, 

354
00:26:38,100 --> 00:26:41,300
correct? 
No, that's not correct. 

355
00:26:42,200 --> 00:26:49,700
The studies looking at neu5gc, 
which is all only present and 

356
00:26:49,700 --> 00:26:54,800
beef lamb and pork and its 
association with tumor. 

357
00:26:54,800 --> 00:26:59,600
Cloaking is, I mean, it's pretty
impressive, scary evidence. 

358
00:26:59,700 --> 00:27:05,900
So so that's regardless of, you 
know, what else is being eaten. 

359
00:27:06,800 --> 00:27:09,400
So in other words, I'm number 
one. 

360
00:27:09,600 --> 00:27:12,800
Don't particularly want to 
develop cancer and if I do, I 

361
00:27:12,800 --> 00:27:19,500
certainly don't want the cancer 
cells to evade my immune systems

362
00:27:19,500 --> 00:27:22,000
detection. 
Yeah, definitely have to read up

363
00:27:22,000 --> 00:27:25,200
on that up to have you send it 
to me via email or something 

364
00:27:25,200 --> 00:27:26,900
after this is over. 
I'll do some reading on that 

365
00:27:27,300 --> 00:27:29,100
actually. 
It's in the black Paradox. 

366
00:27:29,100 --> 00:27:30,600
You can notice references. 
Yep. 

367
00:27:30,600 --> 00:27:34,400
Nice neu5gc. 
So, what is your, I mean, are 

368
00:27:34,400 --> 00:27:37,000
you not eating much red? 
Meat, are you sticking mostly 

369
00:27:37,000 --> 00:27:38,500
like fish and things of that 
nature? 

370
00:27:38,800 --> 00:27:44,900
Well, I am a what I describe as 
a veg. 

371
00:27:45,000 --> 00:27:52,800
Aquarian I eat mostly plants and
then you see on the weekends, my

372
00:27:52,800 --> 00:28:02,000
wife and I eat wild, shellfish 
mollusk, clams, oysters, wild 

373
00:28:02,400 --> 00:28:08,000
shrimp, wild Lobster. 
And we do so for reasons that I 

374
00:28:08,000 --> 00:28:12,800
go into in In the new book, but 
I grew up in Omaha Nebraska. 

375
00:28:12,900 --> 00:28:18,800
And so about every about every 
three months, so we'll share a 

376
00:28:18,800 --> 00:28:27,000
grass-fed grass-finished, steak,
we will eat pastured poultry. 

377
00:28:27,000 --> 00:28:31,400
It's hard to find, but we will, 
and but that's about it. 

378
00:28:33,400 --> 00:28:36,900
What about the the concern with 
cholesterol as relates to eat 

379
00:28:36,900 --> 00:28:39,500
more saturated fats? 
I mean, you being a cardiologist

380
00:28:39,500 --> 00:28:42,200
and carnivores, for instance, 
eating lots of animals high in 

381
00:28:42,200 --> 00:28:44,900
saturated fats, is there a 
pretty big red flag there in 

382
00:28:44,900 --> 00:28:48,400
your opinion? 
So it's not so cholesterol, 

383
00:28:48,400 --> 00:28:52,700
really has nothing to do with 
coronary artery disease. 

384
00:28:54,200 --> 00:29:00,300
What, what does produce coronary
artery disease is inflammation 

385
00:29:00,600 --> 00:29:04,000
on the surface of blood. 
Oils and cholesterol. 

386
00:29:04,000 --> 00:29:08,300
Just happens to be an innocent 
bystander that if you will, is, 

387
00:29:08,300 --> 00:29:12,600
is spackling compound, that 
patches these areas of 

388
00:29:12,600 --> 00:29:17,600
inflammation. 
So you could have patience, and 

389
00:29:17,600 --> 00:29:21,600
I have them who have total 
cholesterol is of over, 500 and 

390
00:29:22,000 --> 00:29:30,100
ldls of 250-300 but they have, 
absolutely, no inflammation on 

391
00:29:30,100 --> 00:29:33,000
the surface of their blood 
vessels, which we Can measure 

392
00:29:34,300 --> 00:29:38,300
and they do not oxidize their 
cholesterol. 

393
00:29:38,300 --> 00:29:41,600
And if you like the cholesterol 
theory of heart disease 

394
00:29:42,100 --> 00:29:46,500
cholesterol has to be oxidized 
to stick to blood vessels and we

395
00:29:46,500 --> 00:29:50,200
can measure that other doctors 
can measure that and I've 

396
00:29:50,200 --> 00:29:56,900
published data that simple 
supplements, like polyphenol 

397
00:29:56,900 --> 00:30:03,000
containing foods like olive oil 
like grape seed extract Like a 

398
00:30:03,000 --> 00:30:07,000
supplement called pycnogenol 
which is French Maritime tree. 

399
00:30:07,000 --> 00:30:13,300
Bart can actually eliminate 
inflammation on the surface of 

400
00:30:13,300 --> 00:30:19,100
blood vessels and when people 
stop taking these compounds it 

401
00:30:19,100 --> 00:30:24,200
comes back. 
So yeah I really could care less

402
00:30:24,500 --> 00:30:30,200
about cholesterol. 
As long as people don't have 

403
00:30:30,200 --> 00:30:32,000
inflammation on the inside of 
their blood. 

404
00:30:32,100 --> 00:30:34,300
Puzzles. 
And since you brought up 

405
00:30:34,300 --> 00:30:40,600
lectins, earlier lectins are one
of the known reasons to have 

406
00:30:41,600 --> 00:30:44,300
inflammation on the surface of 
blood vessels lectins. 

407
00:30:44,600 --> 00:30:49,500
Actually stick to sugar 
molecules on the surface of 

408
00:30:49,508 --> 00:30:53,700
blood vessels just like they 
stick to the lining of joints 

409
00:30:53,700 --> 00:30:58,900
and just like they stick to the 
communication between one nerve 

410
00:30:58,900 --> 00:31:04,800
and another, they they are. 
Literally sugar molecule seeking

411
00:31:05,200 --> 00:31:10,500
missiles and they do a really 
good job of Mischief. 

412
00:31:11,000 --> 00:31:14,700
So, what's the best proxy for 
someone that is concerned about 

413
00:31:14,900 --> 00:31:16,500
their cholesterol? 
For instance, if they want to 

414
00:31:16,500 --> 00:31:19,600
measure the inflammation in the 
lining of their arteries and 

415
00:31:19,600 --> 00:31:22,200
blood vessels, what is what is 
their best route? 

416
00:31:22,200 --> 00:31:26,900
They're like, get a CAT scan. 
No, those are useless. 

417
00:31:27,000 --> 00:31:32,200
There's really no correlation 
between coronary calcification 

418
00:31:32,800 --> 00:31:38,800
and plaque on the inside of the 
blood vessels and that's why if 

419
00:31:38,800 --> 00:31:44,400
there was a good correlation and
Medicare and insurance would pay

420
00:31:44,400 --> 00:31:49,300
for that test, but Medicare and 
insurance doesn't pay for a 

421
00:31:49,300 --> 00:31:54,700
coronary calcium, scan because 
there is no Definitive 

422
00:31:54,700 --> 00:31:58,400
correlation between coronary 
calcification and plaque on the 

423
00:31:58,400 --> 00:32:02,600
inside of blood vessels. 
And for my Cardiology friends 

424
00:32:02,700 --> 00:32:07,400
who think there is a 
correlation, I always refer them

425
00:32:07,400 --> 00:32:15,700
to the paper that shows statin 
drugs actually increase coronary

426
00:32:15,700 --> 00:32:22,000
calcification and if we were so 
worried about it and we think 

427
00:32:22,000 --> 00:32:26,000
that statin drugs read Zeus 
heart disease. 

428
00:32:26,000 --> 00:32:30,300
Then why would I want to take a 
Statin drug and increase my 

429
00:32:30,300 --> 00:32:32,700
coronary artery calcification 
and yet? 

430
00:32:32,700 --> 00:32:37,900
That's what happens in humans. 
So yeah, so no, you don't want 

431
00:32:37,900 --> 00:32:42,100
to do that. 
It's really easy, it's paid for 

432
00:32:42,100 --> 00:32:45,200
by insurance, it's paid for by 
Medicare. 

433
00:32:45,900 --> 00:32:55,500
The simplest test is Ox, L DL, 
0, x LDL oxidized LDL A better 

434
00:32:55,500 --> 00:33:02,100
test, which really chose you. 
What exactly is happening with 

435
00:33:02,200 --> 00:33:09,400
all the different forms of 
cholesterol is called Ox P. 

436
00:33:09,400 --> 00:33:15,800
El capital P capital L stands 
for phospholipids dash, Appo 

437
00:33:15,800 --> 00:33:22,800
APO, capital B. 
So Ox po, Appleby is really the 

438
00:33:22,800 --> 00:33:27,800
definitive way. 
Of determining, whether there is

439
00:33:27,800 --> 00:33:33,300
any risk of cholesterol 
attacking your blood vessels. 

440
00:33:33,300 --> 00:33:35,800
I guess it's a nice way of 
saying it. 

441
00:33:36,100 --> 00:33:39,300
So anybody that this just been 
to the dock for the general 

442
00:33:39,400 --> 00:33:42,300
checkup and is there pushing 
them to get a Statin? 

443
00:33:42,300 --> 00:33:44,900
They should they should go test 
that first and foremost. 

444
00:33:45,400 --> 00:33:49,500
Well yeah, but first, and 
foremost before they do that the

445
00:33:49,500 --> 00:33:56,600
strongest correlation with A 
cholesterol profile and 

446
00:33:56,600 --> 00:34:00,700
developing the coronary artery 
disease is actually elevated 

447
00:34:00,700 --> 00:34:03,700
triglycerides. 
Triglycerides are the first form

448
00:34:03,700 --> 00:34:07,800
of fat that we manufacture from 
sugars and starches. 

449
00:34:08,600 --> 00:34:12,900
I could have you eat a pound of 
butter and your triglycerides 

450
00:34:12,900 --> 00:34:16,800
would be 20. 
On the other hand, I could have 

451
00:34:16,800 --> 00:34:21,199
you eat a bowl of popcorn and 
your triglycerides would be 150 

452
00:34:21,699 --> 00:34:24,000
and that would scare me to 
death. 

453
00:34:24,699 --> 00:34:27,699
I'm a really mean guy. 
I make my patients get their 

454
00:34:27,699 --> 00:34:35,699
triglycerides down to 40 to 50 
triglycerides as normal of 150s 

455
00:34:35,699 --> 00:34:40,600
been artificially elevated 
because I've yet to see a human 

456
00:34:40,600 --> 00:34:47,100
being who has elevated LDL with 
low triglycerides. 

457
00:34:47,900 --> 00:34:51,699
Plus if people are playing with 
their cholesterol numbers and 

458
00:34:51,699 --> 00:34:55,900
you want to avoid heart disease,
you Want your HDL, the so-called

459
00:34:55,900 --> 00:35:01,800
good cholesterol to be equal to 
or preferably higher than 

460
00:35:01,800 --> 00:35:04,900
triglycerides. 
Let me give you a personal 

461
00:35:04,900 --> 00:35:12,200
example. 
When when I met Big Ed, I had a 

462
00:35:12,200 --> 00:35:19,700
triglycerides of about well not 
of about 166 and my HDL was 32 

463
00:35:19,700 --> 00:35:23,800
which is horribly low. 
And I was assured that this was 

464
00:35:24,400 --> 00:35:29,700
Because my father followed the 
same pattern, imagine my shock. 

465
00:35:30,100 --> 00:35:36,600
And when I took my triglycerides
down to 30 in my HD L went to a 

466
00:35:36,600 --> 00:35:44,100
tee, I have the same genes that 
I had when my HDL was 32 and my 

467
00:35:44,100 --> 00:35:49,200
triglycerides were 166. 
What change was the food? 

468
00:35:49,200 --> 00:35:54,000
I ate and this is actually what 
made me. 

469
00:35:54,200 --> 00:35:59,300
Me resigned my position, start 
teaching people how to eat 

470
00:35:59,300 --> 00:36:04,100
because people can absolutely 
positively dial in whatever 

471
00:36:04,100 --> 00:36:09,000
number they want to appear. 
And we have a number of patients

472
00:36:09,000 --> 00:36:13,800
who have been told to take a 
Statin drug by a well-meaning 

473
00:36:14,500 --> 00:36:19,500
cardiologist. 
And instead they come see me and

474
00:36:19,500 --> 00:36:23,200
go back to their cardiologist 
and cardiologist looks at their 

475
00:36:23,200 --> 00:36:25,500
new blood work. 
And As boy, aren't you? 

476
00:36:25,508 --> 00:36:27,800
Glad I put you on that Statin 
and they go. 

477
00:36:27,800 --> 00:36:31,100
Well as a matter of fact, I'm 
not on one and they're 

478
00:36:31,100 --> 00:36:35,400
flabbergasted. 
Very, very distinguished 

479
00:36:35,400 --> 00:36:38,200
cardiologist. 
At Cedars-Sinai is now a good 

480
00:36:38,200 --> 00:36:42,300
friend of mine, just by having a
few patients in common and 

481
00:36:42,300 --> 00:36:45,600
seeing what happens. 
And I know you mentioned, you're

482
00:36:45,600 --> 00:36:50,700
not tracking macros or calories 
but via the recommended food. 

483
00:36:50,700 --> 00:36:52,200
You're suggesting people 
consume. 

484
00:36:52,300 --> 00:36:54,900
Would you, would you say that 
the higher Percentage of their 

485
00:36:54,900 --> 00:36:57,800
calories are likely coming from 
good quality, dietary fats. 

486
00:36:59,800 --> 00:37:02,400
Wait, I'm sorry. 
You broke up on that last part. 

487
00:37:02,900 --> 00:37:05,800
Would you, would you venture to 
say that a good number of the 

488
00:37:05,808 --> 00:37:07,500
people. 
You're recommending nutritional 

489
00:37:07,500 --> 00:37:11,500
advice to are probably consuming
a relatively High, you know, 

490
00:37:11,500 --> 00:37:14,200
concentration their calories 
from quality dietary fats, all 

491
00:37:14,200 --> 00:37:19,500
in all. 
Um no not necessarily. 

492
00:37:19,500 --> 00:37:24,700
I think we see we should be a 
huge mixture of people. 

493
00:37:24,700 --> 00:37:30,000
I have a huge number of people 
who have been on On the 

494
00:37:30,000 --> 00:37:35,300
traditional ketogenic diet that 
has failed them miserably and 

495
00:37:35,300 --> 00:37:38,500
they're eating a whole lot of 
dietary fats. 

496
00:37:38,500 --> 00:37:46,000
And when we reduce their dietary
fats and change the timing of 

497
00:37:46,000 --> 00:37:51,400
their eating and add other ways 
to accomplish what they're 

498
00:37:51,400 --> 00:37:57,300
trying to do. 
With high-fat diet, we get some 

499
00:37:57,500 --> 00:38:00,200
pretty amazing results and that 
That's one of the reasons I 

500
00:38:00,200 --> 00:38:02,900
wrote the new book. 
Yes, dive into that. 

501
00:38:03,100 --> 00:38:05,100
So the new book unlocking, the 
Kyoko. 

502
00:38:05,100 --> 00:38:08,900
What was the the primary 
Catalyst for that was the 

503
00:38:08,908 --> 00:38:13,800
motivation behind writing them? 
Well I've been a big fan of the 

504
00:38:13,800 --> 00:38:17,100
ketogenic diet for over 20 
years. 

505
00:38:17,100 --> 00:38:22,000
I it's a part of all of my 
books, the plant Paradox as a 

506
00:38:23,700 --> 00:38:28,600
key, do intensive care program 
that we used successfully in 

507
00:38:28,600 --> 00:38:31,400
people. 
Are always shocked about the 

508
00:38:31,500 --> 00:38:38,400
number of carbohydrate 
containing foods in my ketogenic

509
00:38:38,400 --> 00:38:42,300
diet and yet we have really good
success with it. 

510
00:38:42,500 --> 00:38:47,000
So when I was writing the energy
Paradox which was my last book, 

511
00:38:47,900 --> 00:38:57,600
I wanted to spend some time 
showing how ketones Are so 

512
00:38:57,600 --> 00:39:03,000
useful for improving 
mitochondrial, efficiency and 

513
00:39:03,000 --> 00:39:10,000
fat burning efficiency. 
And as I was trying to dig into 

514
00:39:10,000 --> 00:39:14,300
more literature to explain the 
mechanism that this supposedly 

515
00:39:14,300 --> 00:39:19,100
happened. 
I realized that in fact ketones 

516
00:39:19,900 --> 00:39:23,800
aren't a miraculous fuel. 
In fact, they're a pretty lousy 

517
00:39:23,800 --> 00:39:28,600
Fuel and this this was has been 
known about actually since the 

518
00:39:28,600 --> 00:39:39,700
1970s and as recently as 2008 
work out of Harvard show that in

519
00:39:39,700 --> 00:39:48,000
humans on a full ketogenic diet 
at full ketosis, that ketones 

520
00:39:48,000 --> 00:39:53,800
are only able to meet thirty 
percent of the body's energy 

521
00:39:53,800 --> 00:39:59,000
requirement for fuel. 
And at full ketosis. 

522
00:39:59,200 --> 00:40:06,000
The brain still needs 30 to 40 
percent of its calories as 

523
00:40:06,000 --> 00:40:10,700
glucose not ketones, even though
there are present in huge 

524
00:40:10,700 --> 00:40:13,600
numbers. 
And so, you sit there and go, 

525
00:40:13,600 --> 00:40:19,000
we'll wait a minute that flies 
in the face of what we think 

526
00:40:19,300 --> 00:40:23,800
ketones are doing. 
And so the unlocking, the keto 

527
00:40:23,800 --> 00:40:29,800
code is actually Li Hao ketones 
are not a great fuel, but 

528
00:40:29,800 --> 00:40:36,800
ketones are a very impressive. 
Signaling molecule that tells 

529
00:40:36,800 --> 00:40:40,400
mitochondria the energy 
producing organelles in our 

530
00:40:40,400 --> 00:40:47,800
cells to as strange, as it may 
seem waste fuel to waste 

531
00:40:47,800 --> 00:40:54,500
calories and to become in fact, 
in efficient at converting 

532
00:40:54,500 --> 00:41:01,900
calories, Into energy and that 
Revelation actually happened. 

533
00:41:02,000 --> 00:41:07,100
You know, a small paper that was
published in the year 2000 by a 

534
00:41:07,100 --> 00:41:12,300
researcher by the name of Martin
brand and the paper and I urge 

535
00:41:12,300 --> 00:41:16,200
your listeners to read it. 
It's quick, it's easy called 

536
00:41:16,300 --> 00:41:24,500
uncoupling to survive and it's 
about how when you're starving 

537
00:41:24,500 --> 00:41:28,700
to death. 
You have to save your 

538
00:41:28,700 --> 00:41:34,300
mitochondria from dying because 
if they die, that's the end of 

539
00:41:34,300 --> 00:41:38,600
you. 
And so mitochondria go through a

540
00:41:39,100 --> 00:41:44,100
method of protecting themselves 
which is called mitochondrial 

541
00:41:44,100 --> 00:41:47,000
uncoupling. 
Most people can't think of 

542
00:41:47,000 --> 00:41:52,100
uncoupling is getting a divorce 
or breaking up but in fact 

543
00:41:52,200 --> 00:41:58,700
mitochondria have Ways of 
wasting a lot of the calories 

544
00:41:58,700 --> 00:42:03,500
that we eat normally. 
In fact, 30% of all the calories

545
00:42:03,500 --> 00:42:10,800
we eat, never enter fully the 
electron transport chain or made

546
00:42:10,800 --> 00:42:21,800
into a teepee there in instead 
uncoupled from burning as a, as 

547
00:42:21,800 --> 00:42:27,200
a calorie to produce ATP. 
But instead produce Eat and 

548
00:42:27,400 --> 00:42:32,500
these uncoupling proteins that 
control, this system were 

549
00:42:32,500 --> 00:42:36,500
discovered actually as far back 
as 1978. 

550
00:42:36,600 --> 00:42:42,200
And if you look for instance, at
super old people folks in their 

551
00:42:42,200 --> 00:42:44,900
late 90s, early 100's who are 
thriving. 

552
00:42:45,800 --> 00:42:49,500
One of the things that's 
fascinating about them is they 

553
00:42:49,500 --> 00:42:57,600
have the most uncoupled 
mitochondria of of anyone So the

554
00:42:57,900 --> 00:43:01,100
phrase exactly right uncouple to
survive. 

555
00:43:01,700 --> 00:43:05,800
And the book unlocking, the keto
code actually takes people 

556
00:43:05,800 --> 00:43:12,900
through the various tricks and 
hacks to uncouple their 

557
00:43:12,900 --> 00:43:19,900
mitochondria, and you don't have
to do a boring miserable, 

558
00:43:19,900 --> 00:43:23,200
high-fat diet to accomplish it. 
That's the fun part. 

559
00:43:24,000 --> 00:43:27,300
So what is the like I want to 
give away your book here too 

560
00:43:27,300 --> 00:43:30,800
much but what is during the the 
mechanism is happening tonight? 

561
00:43:30,800 --> 00:43:33,600
When you go through, what are 
these tricks and hacks or what 

562
00:43:33,600 --> 00:43:36,700
are some main ones consists of? 
Because I mean a lot of people 

563
00:43:36,700 --> 00:43:39,600
are seeing great performance 
success in switching to a 

564
00:43:39,607 --> 00:43:42,700
ketogenic diet. 
So is that kind of Happening by 

565
00:43:42,700 --> 00:43:45,300
default and them or what? 
What's going on there? 

566
00:43:46,200 --> 00:43:50,000
Well, remember, when you're on 
ketogenic diet, you've pretty 

567
00:43:50,000 --> 00:43:54,000
much eliminated, lectin 
containing foods and I think 

568
00:43:54,000 --> 00:44:00,800
that explains why people who do 
Paleo diet, people who do Peter 

569
00:44:00,800 --> 00:44:04,900
genic, dive people do a low-carb
diet, people who do high protein

570
00:44:04,900 --> 00:44:11,900
diet, the thing that binds, all 
those together is the avoidance 

571
00:44:11,900 --> 00:44:15,600
of lectins, and the ceiling of 
the gut. 

572
00:44:15,700 --> 00:44:21,900
But on the other hand, but we do
know that continuous ketosis is 

573
00:44:22,000 --> 00:44:26,800
is really a performance killer 
for two reasons. 

574
00:44:26,900 --> 00:44:32,300
Number one, ketones signal 
mitochondria to protect 

575
00:44:32,300 --> 00:44:38,200
themselves at all costs. 
And to if they're going to make 

576
00:44:38,300 --> 00:44:42,500
proteins to make mitochondrial 
proteins to make more 

577
00:44:42,500 --> 00:44:49,000
mitochondria and to Not make 
proteins for muscle repair and 

578
00:44:49,000 --> 00:44:54,400
for building muscle. 
And that explains why the number

579
00:44:54,400 --> 00:45:02,100
of people in chronic ketosis 
24/7 365 days a year, begin to 

580
00:45:02,100 --> 00:45:05,500
get muscle wasting. 
We know that the muscles become 

581
00:45:05,500 --> 00:45:09,600
insulin resistant and it also 
explains why so many people 

582
00:45:09,600 --> 00:45:15,300
start to run and elevating. 
It fasting glucose, all in an 

583
00:45:15,300 --> 00:45:17,500
effort. 
Effort for the mitochondria to 

584
00:45:17,500 --> 00:45:20,500
protect themselves and to starve
the muscles. 

585
00:45:21,000 --> 00:45:26,200
In fact, as I talked about in 
the book, we know that Elite 

586
00:45:26,400 --> 00:45:35,400
race walkers on a ketogenic diet
can achieve the performance of a

587
00:45:35,400 --> 00:45:41,600
more carbohydrate based diet but
only at the expense of increased

588
00:45:41,600 --> 00:45:44,400
oxygen consumption and faster 
breathing. 

589
00:45:44,800 --> 00:45:51,500
And we go into the Mechanism of 
that in the book and you cannot 

590
00:45:52,800 --> 00:45:58,000
provide adequate fuel for 
muscles using ketones. 

591
00:45:58,400 --> 00:46:02,600
You can certainly provide 
adequate fuel for muscles using 

592
00:46:02,600 --> 00:46:09,100
free fatty acids but ketones as 
a fuel are pretty lousy and 

593
00:46:09,500 --> 00:46:13,900
doctors Cahill and Owens proved 
this at Harvard. 

594
00:46:13,900 --> 00:46:19,200
As recently as 2008. 
So anyone that's fat adapted. 

595
00:46:19,200 --> 00:46:22,700
I mean that they're not trying 
to use ketones exclusively as a 

596
00:46:22,707 --> 00:46:25,100
fuel source. 
I mean, a large budget, my 

597
00:46:25,100 --> 00:46:27,100
calories and energy comes from 
fat. 

598
00:46:27,100 --> 00:46:30,200
I'm not consuming carbohydrates.
So my predominant energy source 

599
00:46:30,200 --> 00:46:34,100
is the fatty acids. 
So I like know of anybody but 

600
00:46:34,100 --> 00:46:38,600
exclusively with ketones, but 
but remember T tones exist? 

601
00:46:38,800 --> 00:46:43,600
Really, for only one reason. 
And that is free, fatty acids 

602
00:46:43,800 --> 00:46:47,100
are too big and not water 
soluble. 

603
00:46:47,200 --> 00:46:51,300
Of to get through the 
blood-brain barrier, right? 

604
00:46:51,500 --> 00:46:57,300
And so ketones are short, 
water-soluble fatty acids, that 

605
00:46:57,300 --> 00:47:01,200
can diffuse through the 
blood-brain barrier and provide 

606
00:47:01,500 --> 00:47:05,900
quite frankly, an emergency fuel
source for the brain. 

607
00:47:06,900 --> 00:47:14,800
But even at full ketosis. 
The brain can't get enough fuel 

608
00:47:15,000 --> 00:47:22,700
from ketones and It uses glucose
and that's one of the I think 

609
00:47:23,300 --> 00:47:29,000
long-term down down sides of a 
continuous ketogenic diet, when 

610
00:47:29,000 --> 00:47:32,500
you're when you're fat d'ampton.
I mean the brain have absolutely

611
00:47:32,500 --> 00:47:35,800
does need glucose but you're 
able to give that internally 

612
00:47:35,800 --> 00:47:40,300
through gluconeogenesis to the 
amount necessary for that brain 

613
00:47:40,500 --> 00:47:45,900
and its function, correct. 
And if you're really on for 

614
00:47:45,900 --> 00:47:50,100
instance, an 80, Sent fat diet. 
He may not be getting enough 

615
00:47:50,100 --> 00:47:56,200
protein to accomplish that 
gluconeogenesis and you waste 

616
00:47:56,300 --> 00:48:01,000
your own protein to do it. 
I have several colleagues who 

617
00:48:01,000 --> 00:48:08,200
have attempted 24/7 365 day, 
ketogenic diet and develop 

618
00:48:08,200 --> 00:48:13,300
sarcopenia for that exact 
reason, so on a on a very high 

619
00:48:13,400 --> 00:48:17,200
fat diet. 
So am I like an anomaly Or 

620
00:48:17,200 --> 00:48:19,700
something because I've have been
strict, ketogenic for seven 

621
00:48:19,700 --> 00:48:22,100
years now, and I am a 
competitive bodybuilder. 

622
00:48:22,100 --> 00:48:24,700
So I build muscle with every 
year that passes my physique 

623
00:48:24,700 --> 00:48:47,100
improves my markers improve, I'm
certainly not sarcopenia. 

624
00:48:47,200 --> 00:48:51,900
Sent carbohydrates. 
And though that's what I'm 

625
00:48:51,900 --> 00:48:57,000
talking about. 
By definition is the classic 

626
00:48:57,000 --> 00:49:00,600
ketogenic diet. 
That was established at the Mayo

627
00:49:00,600 --> 00:49:03,400
Clinic in 1920 catch. 
Okay. 

628
00:49:03,400 --> 00:49:04,200
Yeah. 
That makes sense. 

629
00:49:04,200 --> 00:49:07,200
I definitely eat a lot of 
protein, but I'm taken in quite 

630
00:49:07,200 --> 00:49:09,600
a high percentage of calories, 
from dietary fat, but I'm eating

631
00:49:09,600 --> 00:49:12,300
enough total calories that. 
Even with that high fat 

632
00:49:12,300 --> 00:49:15,300
percentage, I'm taking in, you 
know, a protein for my, for my 

633
00:49:15,300 --> 00:49:18,300
needs. 
Which leads me to another 

634
00:49:18,300 --> 00:49:21,300
interesting question. 
When it comes to what you've 

635
00:49:21,300 --> 00:49:24,500
discovered in doing what you've 
done for the past several years,

636
00:49:25,000 --> 00:49:28,100
do you notice there being any 
differentiating factor between 

637
00:49:28,200 --> 00:49:31,100
being in a caloric Surplus 
versus that of a deficit? 

638
00:49:31,100 --> 00:49:33,900
I mean, is there like with your 
energy Paradox book? 

639
00:49:33,900 --> 00:49:38,500
For instance, did you equate for
eternity track calories? 

640
00:49:38,500 --> 00:49:40,600
You said, but is there like a 
significant differentiating 

641
00:49:40,600 --> 00:49:44,100
factor with someone that's in a 
deficit versus a surplus? 

642
00:49:44,700 --> 00:49:54,900
Well, it depends on who you're 
eating the calories for my job. 

643
00:49:54,900 --> 00:50:01,900
As far as I can tell, is to eat 
most of my calories for my gut 

644
00:50:01,900 --> 00:50:08,100
microbiome and giving them what 
they want. 

645
00:50:08,100 --> 00:50:15,100
And quite frankly, I'm their 
home and we now know that Is a 

646
00:50:15,100 --> 00:50:21,100
very symbiotic relationship 
between the gut microbiome and 

647
00:50:21,100 --> 00:50:29,200
us and My Philosophy is eat for 
them and as long as you're 

648
00:50:29,200 --> 00:50:32,600
eating for them, they'll take 
care of their home. 

649
00:50:32,600 --> 00:50:39,500
You and I think one of the one 
of the issues that I talked 

650
00:50:39,500 --> 00:50:45,500
about and a more traditional 
ketogenic diet is, Is that it 

651
00:50:45,500 --> 00:50:51,000
doesn't provide adequate 
nutrition for the gut microbiome

652
00:50:51,000 --> 00:50:56,600
to do its job and some so I 
don't I I eat for them. 

653
00:50:57,200 --> 00:50:59,300
It's like Jacqueline. 
Jacqueline. 

654
00:50:59,900 --> 00:51:02,400
I got to know in his later 
years. 

655
00:51:03,500 --> 00:51:07,400
I happen to think of him as the 
Godfather of fitness and maybe 

656
00:51:07,400 --> 00:51:10,200
you'll agree. 
But that Jacqueline used to have

657
00:51:10,200 --> 00:51:14,100
a famous expression. 
If it tastes good, spit it out. 

658
00:51:14,800 --> 00:51:20,600
And he was actually saying after
talking to him he said we 

659
00:51:20,600 --> 00:51:22,900
actually should not be eating 
for us. 

660
00:51:22,900 --> 00:51:28,900
We should be eating for our gut 
microbiome and you know it 

661
00:51:28,900 --> 00:51:31,900
pretty well. 
I think you still be alive. 

662
00:51:31,900 --> 00:51:37,500
He developed pneumonia. 
And from what I understand did 

663
00:51:37,500 --> 00:51:41,700
not take antibiotics which I'm 
not a big fan of but sometimes 

664
00:51:41,700 --> 00:51:46,800
you need them some but he made. 
It to 96 and perfect health. 

665
00:51:47,200 --> 00:51:48,700
That's pretty rapid age for 
sure. 

666
00:51:49,300 --> 00:51:53,600
Yep. 
I meant to dive deeper into the 

667
00:51:54,100 --> 00:51:56,300
mechanistic property of the 
uncoupling. 

668
00:51:57,800 --> 00:52:01,100
What are some tangible, action 
steps so to speak of? 

669
00:52:01,100 --> 00:52:03,600
What are some changes that you 
make in someone's nutrition to 

670
00:52:03,600 --> 00:52:06,800
really amplify that uncoupling 
effect? 

671
00:52:07,700 --> 00:52:11,400
Well, the cool thing is, there's
lots of ways to uncouple 

672
00:52:11,400 --> 00:52:17,700
mitochondria, besides ketones. 
For instance, ketones, do 

673
00:52:17,700 --> 00:52:21,900
uncouple mitochondria. 
But you can generate ketones 

674
00:52:22,400 --> 00:52:28,200
from MCT oil and you can have 
all the carbohydrates you want 

675
00:52:28,300 --> 00:52:32,300
and have MCT oil and you will 
generate ketones. 

676
00:52:32,800 --> 00:52:41,900
That's been well, shown there is
a host of MCT fats in both goat 

677
00:52:41,900 --> 00:52:47,700
and sheep milk products. 
Thirty percent of all the fat in

678
00:52:47,700 --> 00:52:52,800
goat and sheep cheese, goat, and
sheep, yogurt, is actually MCT. 

679
00:52:53,500 --> 00:53:00,200
And so you can actually get MCTS
while eating go cheap products 

680
00:53:00,200 --> 00:53:05,800
which I recommend in the new 
book and there's actually two 

681
00:53:05,800 --> 00:53:09,700
blue zones. 
The longest-living people in the

682
00:53:09,700 --> 00:53:13,700
world who are blue zones, not 
because they're eating grains 

683
00:53:13,700 --> 00:53:17,600
and beans. 
But because they're eating goat 

684
00:53:17,600 --> 00:53:23,300
and sheep cheeses and that's the
mountainous area of Sardinia and

685
00:53:23,300 --> 00:53:26,300
Nagoya, Peninsula and Costa 
Rica. 

686
00:53:26,500 --> 00:53:30,900
And there's beautiful evidence. 
That shows it's the goat and 

687
00:53:30,900 --> 00:53:34,000
sheep products that they, that 
makes the difference, not the 

688
00:53:34,000 --> 00:53:36,400
grains and beans with that makes
the difference. 

689
00:53:37,200 --> 00:53:40,400
So, that's one. 
Is it worthwhile for someone to 

690
00:53:40,400 --> 00:53:44,400
to check Ketone levels on a 
somewhat regular basis to ensure

691
00:53:44,400 --> 00:53:50,200
that They have circulating blood
ketones know, you really want to

692
00:53:50,200 --> 00:53:53,400
cycle in and out of ketosis on a
daily basis. 

693
00:53:54,200 --> 00:53:59,900
We're designed to cycle in and 
out normally, every 24 hours 

694
00:54:00,400 --> 00:54:04,600
into ketosis and back out of 
ketosis. 

695
00:54:05,200 --> 00:54:09,900
And that's, that's our design. 
Now, the vast majority of people

696
00:54:10,800 --> 00:54:17,800
cannot do that they have no, 
Flexibility in being able to 

697
00:54:17,800 --> 00:54:22,700
burn fat as a fuel or even 
generate ketones and the book 

698
00:54:22,700 --> 00:54:26,300
takes people through the various
ways to do this. 

699
00:54:26,300 --> 00:54:33,600
Now in addition to MCT oil, 
providing ketones without a 

700
00:54:33,600 --> 00:54:37,900
ketogenic diet, there are many 
other ways to uncouple 

701
00:54:37,900 --> 00:54:42,300
mitochondria. 
And some of the easiest ways are

702
00:54:42,300 --> 00:54:46,300
short chain fatty acids that are
Generated by our gut, 

703
00:54:46,300 --> 00:54:50,400
microbiome, by giving them, 
fibrous Foods date and that's 

704
00:54:50,400 --> 00:54:56,300
butyrate and acetate. 
For instance, butyrate can be 

705
00:54:56,300 --> 00:55:01,600
converted into beta hydroxy 
butyrate which most eugenic 

706
00:55:01,600 --> 00:55:06,000
folks know is BH B. 
So, the substrate for that is 

707
00:55:06,000 --> 00:55:08,500
butyrate but butyrate in its 
own, right? 

708
00:55:08,500 --> 00:55:11,500
Can actually uncouple 
mitochondria just as well. 

709
00:55:13,300 --> 00:55:17,200
Interestingly enough, apple 
cider vinegar or any vinegar for

710
00:55:17,200 --> 00:55:22,200
that matter works. 
Because acetic acid is a strong 

711
00:55:22,200 --> 00:55:26,800
mitochondrial on coupler. 
The other thing that's fun is 

712
00:55:26,800 --> 00:55:34,100
that polyphenols which are those
bright-coloured colors in 

713
00:55:34,100 --> 00:55:38,700
fruits, and leaves, and 
vegetables are actually profound

714
00:55:38,700 --> 00:55:40,800
mitochondrial and couplers in 
and of themselves. 

715
00:55:40,800 --> 00:55:44,600
And I've been Searching 
polyphenols. 

716
00:55:44,600 --> 00:55:52,100
Now for 25 years and little did 
I know that their power is not 

717
00:55:52,100 --> 00:55:57,500
as an antioxidant they are not 
antioxidants but they are 

718
00:55:58,000 --> 00:56:01,700
marvelous mitochondrial and 
couplers. 

719
00:56:03,300 --> 00:56:06,100
When it comes to fruits you 
mentioned fruits fruits have 

720
00:56:06,100 --> 00:56:08,400
been in the in the topic of 
discussion. 

721
00:56:08,400 --> 00:56:10,600
Quite a bit lately within the 
keto low carb space. 

722
00:56:11,400 --> 00:56:14,900
Do you feel like fruits hold a 
pretty prominent place in 

723
00:56:14,900 --> 00:56:18,700
people's diet or should or no 
think not so much? 

724
00:56:18,700 --> 00:56:19,900
Huh? 
No. 

725
00:56:19,900 --> 00:56:24,300
In my original book was famous 
for saying, give fruit. 

726
00:56:24,300 --> 00:56:32,200
The boot fruit is as been bred 
for fructose. 

727
00:56:33,100 --> 00:56:37,600
Great apes, only gain weight 
during fruit season and fruit 

728
00:56:37,600 --> 00:56:40,800
season does not occur your round
in the jungle. 

729
00:56:41,100 --> 00:56:45,500
It only occurs once a year in 
great apes, gain weight by 

730
00:56:45,500 --> 00:56:50,800
converting, the fructose in 
Fruit to fat in the form of 

731
00:56:50,800 --> 00:56:57,500
triglyceride and it'll also 
converts into uric acid. 

732
00:56:57,500 --> 00:57:00,200
Which my good friend David 
Perlmutter, has a new book 

733
00:57:00,500 --> 00:57:05,000
coming out called drop acid. 
And fruit is one of the best 

734
00:57:05,000 --> 00:57:08,900
ways to increase uric acid, 
which can damage your kidneys 

735
00:57:08,900 --> 00:57:11,600
can give you blood pressure 
problems can actually make you 

736
00:57:11,600 --> 00:57:15,600
gain weight and that's why fruit
is really good for weight gain. 

737
00:57:16,100 --> 00:57:19,500
On the other hand, the 
polyphenols and fruit are great.

738
00:57:19,600 --> 00:57:24,200
So when I ask people to do is 
get out there, Jack Lalanne 

739
00:57:24,200 --> 00:57:27,400
juicer, I know you got it 
sitting on a cabinet someplace 

740
00:57:28,000 --> 00:57:32,700
and buy organic fruit and season
juice it. 

741
00:57:33,000 --> 00:57:38,800
Throw away the juice and then 
take the pulp, which has all the

742
00:57:38,800 --> 00:57:45,200
polyphenols and then mix that in
two plain goat or sheep yogurt 

743
00:57:45,200 --> 00:57:50,000
or coconut yogurt or put them in
some silicone ice cube trays and

744
00:57:50,000 --> 00:57:54,900
freeze them and then bring them 
out and stir it into some 

745
00:57:54,900 --> 00:57:58,700
coconut yogurt or some goat and 
sheep yogurt and have yourself 

746
00:57:58,700 --> 00:58:00,900
an ice cream, which I show how 
to do in the book. 

747
00:58:01,300 --> 00:58:02,900
Is that your preferred source of
the pain? 

748
00:58:03,000 --> 00:58:07,000
No. 
Well I take a ton of different 

749
00:58:07,000 --> 00:58:10,000
polyphenols. 
One of the best sources of 

750
00:58:10,000 --> 00:58:14,300
polyphenols that everybody has 
access to on a ketogenic diet is

751
00:58:14,300 --> 00:58:18,500
olive oil. 
There are three blue zones that 

752
00:58:18,500 --> 00:58:21,400
consume a leader of olive oil 
per week. 

753
00:58:21,400 --> 00:58:24,200
That's about 10 tablespoons a 
day. 

754
00:58:25,100 --> 00:58:29,300
There is a very famous study out
of Spain called the predamond 

755
00:58:29,300 --> 00:58:32,800
study looking at people with 
known coronary artery disease. 

756
00:58:33,000 --> 00:58:38,600
Those who were made to consume a
leader of olive oil per week. 

757
00:58:38,800 --> 00:58:42,600
And they actually had not only 
regression of their coronary 

758
00:58:42,600 --> 00:58:46,700
artery disease, but they 
actually had improved memory at 

759
00:58:46,700 --> 00:58:50,900
the end of five years compared 
to a low-fat control group. 

760
00:58:51,000 --> 00:58:55,900
So, olive oil is full of great 
polyphenols. 

761
00:58:57,100 --> 00:59:01,000
So in kind of taking it all that
you said and then bundling it 

762
00:59:01,008 --> 00:59:04,400
all together into a, an actual 
nutritional plan for people 

763
00:59:04,400 --> 00:59:07,800
listening. 
It sounds like make sure you get

764
00:59:07,800 --> 00:59:10,700
plenty of olive oil in. 
Make sure you're getting some 

765
00:59:10,700 --> 00:59:14,900
fish in a lot of veggies that 
are free of lectins, make sure 

766
00:59:14,900 --> 00:59:20,600
getting a protein in and then 
ideally phone, a ketogenic diet,

767
00:59:20,600 --> 00:59:25,000
enough fat, to make sure that 
you're producing ketones so that

768
00:59:25,000 --> 00:59:27,700
you can optimize for that. 
Uncoupling standpoint. 

769
00:59:27,700 --> 00:59:29,200
Is that more or less? 
What I'm picking up. 

770
00:59:30,100 --> 00:59:35,600
Yeah, with the exception of you 
actually to achieve what you 

771
00:59:35,600 --> 00:59:40,500
want from a ketogenic diet, 
which believe it or not is 

772
00:59:40,700 --> 00:59:45,800
mitochondrial and coupling, you 
do not need to eat a high fat 

773
00:59:45,800 --> 00:59:49,700
diet and that's the real 
revelation of unlocking, the 

774
00:59:49,700 --> 00:59:54,100
keto code. 
And this was proven incidentally

775
00:59:54,100 --> 00:59:59,400
in childhood epilepsy studies 
children on the traditional 

776
00:59:59,400 --> 01:00:05,600
ketogenic diet for epilepsy, 
where had growth stature had 

777
01:00:05,600 --> 01:00:10,600
muscle wasting and it was 
abandoned until it was 

778
01:00:10,600 --> 01:00:17,800
resurrected with a MCT oil based
diet for kids where they were 

779
01:00:17,800 --> 01:00:22,100
given a lot more carbohydrates 
and a lot more protein and they 

780
01:00:22,100 --> 01:00:27,400
still had the same anti-seizure 
effect of the Traditional 

781
01:00:27,400 --> 01:00:31,000
high-fat, ketogenic diet. 
And it was actually that 

782
01:00:31,000 --> 01:00:35,800
information that kind of started
me down this road saying, son of

783
01:00:35,800 --> 01:00:38,700
a gun. 
We've got this, we got to eat a 

784
01:00:38,707 --> 01:00:42,900
ton of fat, to get the benefits 
of a keto ketones. 

785
01:00:43,700 --> 01:00:46,400
We don't have to and that's 
unlocking, the, keto coat. 

786
01:00:47,300 --> 01:00:50,800
Now, when it comes to like if 
proteins equated for, for 

787
01:00:50,800 --> 01:00:53,600
instance, you know, protein is 
not a great substrate for 

788
01:00:53,600 --> 01:00:56,400
energy, so someone's going to 
have to get their fuel from 

789
01:00:56,600 --> 01:00:59,900
either dietary fats or dietary 
carbohydrates, and someone's 

790
01:00:59,900 --> 01:01:01,700
following a little carbohydrate 
diet. 

791
01:01:02,000 --> 01:01:04,700
They're probably going to have, 
I'm not suggesting people have a

792
01:01:05,000 --> 01:01:08,100
traditional ketogenic down the 
sense of, you know, 90% of cars 

793
01:01:08,100 --> 01:01:11,100
coming from fat, and very 
minimal protein, and no carbs. 

794
01:01:11,400 --> 01:01:14,500
But if you're taking in enough 
protein and your have a high 

795
01:01:14,500 --> 01:01:17,100
energy expenditure, like if 
you're an athlete, for instance,

796
01:01:17,400 --> 01:01:20,100
you're going to want to have, 
you know, enough dietary fat to 

797
01:01:20,100 --> 01:01:27,200
fuel that demand, True and 
you're right protein, we lose 

798
01:01:27,600 --> 01:01:31,800
30% of the calories and protein 
just in breaking it down and we 

799
01:01:32,200 --> 01:01:36,200
lose it from the inefficiency of
breaking down protein. 

800
01:01:36,500 --> 01:01:45,000
So you're right protein is not a
great source of fuel, but it is 

801
01:01:45,000 --> 01:01:50,700
a great source of making 
glucose, which you do have to 

802
01:01:51,100 --> 01:01:57,800
somehow Compen, say, for on very
high fat diet, and usually it 

803
01:01:57,800 --> 01:01:59,700
comes from protein. 
Gotcha. 

804
01:01:59,700 --> 01:02:01,500
Gotcha. 
Now I'm definitely read the 

805
01:02:01,500 --> 01:02:05,400
book. 
It comes out in March. 20, March

806
01:02:05,400 --> 01:02:08,800
8th, March 8. 
Okay, yeah March 8 and all the 

807
01:02:08,800 --> 01:02:11,700
other studies that you've 
mentioned there, they're 

808
01:02:12,100 --> 01:02:14,000
indicated in the other, the 
prior books is, right. 

809
01:02:14,000 --> 01:02:16,600
There's there's like a page on 
your website that lists all 

810
01:02:16,607 --> 01:02:19,900
these studies out by chance. 
Yeah, actually, if you go to dr.

811
01:02:19,900 --> 01:02:24,000
Gunther e.com. 
You can actually see most of 

812
01:02:24,000 --> 01:02:31,000
most of these studies, but the 
most of the studies that I just 

813
01:02:31,000 --> 01:02:34,400
mentioned a day, are in the new 
book and, you know, highly 

814
01:02:34,400 --> 01:02:37,400
highly referenced awesome. 
Well, I'm almost certainly be 

815
01:02:37,400 --> 01:02:39,100
reading that. 
See what I can learn for sure. 

816
01:02:39,900 --> 01:02:42,300
I'll link that to you websites. 
In the show notes. 

817
01:02:42,300 --> 01:02:44,700
Is there anything else that's in
the pipeline of having a book 

818
01:02:44,700 --> 01:02:46,100
coming out? 
Some pretty big thing in itself,

819
01:02:46,100 --> 01:02:48,600
but anything else you you want 
to direct people to attention 

820
01:02:48,600 --> 01:02:52,800
towards? 
Well, yeah, I mean, Can they can

821
01:02:52,800 --> 01:02:55,700
find me, dr. 
Gunther e.com. 

822
01:02:55,700 --> 01:02:59,400
I supplement, food company is 
done, dream, d.com. 

823
01:02:59,800 --> 01:03:06,600
And actually for your listeners,
if you go to gundry imdb.com and

824
01:03:06,600 --> 01:03:12,500
use the code, gundry will give 
you thirty percent off your 

825
01:03:12,500 --> 01:03:15,100
first order just for your 
listeners. 

826
01:03:15,600 --> 01:03:17,100
Awesome. 
Well, I will definitely link out

827
01:03:17,100 --> 01:03:19,500
to that as well. 
Can't thank you enough for 

828
01:03:19,500 --> 01:03:21,600
taking the time to jump on a 
podcast and chat. 

829
01:03:21,700 --> 01:03:24,100
With me, I'm excited to read the
book, decided to see what I can 

830
01:03:24,100 --> 01:03:27,400
learn and excited to dive in 
deeper to what you're working on

831
01:03:27,400 --> 01:03:28,500
here. 
All right. 

832
01:03:28,500 --> 01:03:30,600
Well, thanks a lot. 
Thanks very much for having me. 

833
01:03:30,600 --> 01:03:35,800
And yes, head on over to gundry.
I'm d.com and put in gundry 30 

834
01:03:35,800 --> 01:03:39,100
and try some polyphenols out. 
Sounds great and I appreciate 

835
01:03:39,100 --> 01:03:40,300
you sir. 
All right. 

836
01:03:40,300 --> 01:03:41,500
Thank you very much. 
Take care. 

837
01:03:21,700 --> 01:03:24,100
With me, I'm excited to read the
book, decided to see what I can 

838
01:03:24,100 --> 01:03:27,400
learn and excited to dive in 
deeper to what you're working on

839
01:03:27,400 --> 01:03:28,500
here. 
All right. 

840
01:03:28,500 --> 01:03:30,600
Well, thanks a lot. 
Thanks very much for having me. 

841
01:03:30,600 --> 01:03:35,800
And yes, head on over to gundry.
I'm d.com and put in gundry 30 

842
01:03:35,800 --> 01:03:39,100
and try some polyphenols out. 
Sounds great and I appreciate 

843
01:03:39,100 --> 01:03:40,300
you sir. 
All right. 

844
01:03:40,300 --> 01:03:41,500
Thank you very much. 
Take care.

