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Well, hello ladies and gents, 
Robert Sykes, Keto savage.com 

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and today I have a special 
guest, Doctor Heather Sanson on 

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the line. 
She just wrote a book reversing 

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Alzheimer's and we dive deep 
into neurological decline and 

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what you can do to prevent that 
or certainly mitigate that from 

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happening as you age. 
We dove deep into lifestyle 

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factors, nutritional changes and
manipulations you can make, the 

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importance of quality sleep, 
removing toxins, all that good 

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stuff. 
She is incredibly passionate 

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about this. 
She has changed so many people's

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lives and it's very evident as 
you, as I talked to her and just

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her zeal and excitement and 
passion for helping people 

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mitigate this and improve their 
quality of life. 

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So I was very grateful to talk 
to her. 

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I learned a ton. 
I've got no doubt that you will 

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take something from this so that
further delay, sit back, relax 

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and enjoy the conversation with 
Doctor Heather Sampson and we 

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are live Doctor Heather 
Sanderson, how are you today? 

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So great to be here. 
Thanks for having me, Robert. 

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I'm excited to be chatting with 
you because you're talking on 

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the importance of diet, 
nutrition and lifestyle factors 

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as it pertains to just hedging 
against all the Alzheimer's and 

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dementia that we seem to be 
plagued with as a society, which

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I think is a topic that hits 
near and dear to a lot of 

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people. 
We all kind of know some of that

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struggle with that. 
So I'm excited to be down into 

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that with you. 
Yeah, it's such a hopeful 

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message that we have because 
there many people don't realize 

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there's so much that we can do 
to prevent delay and yes, even 

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reverse cognitive decline as we 
age. 

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So I know a lot of people 
especially listen this podcast, 

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they have heard the term type 3 
diabetes and that being kind of 

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linked to Alzheimer's dementia. 
But can you can you dive into 

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what that is from a mechanistic 
standpoint and why it's even 

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referred to as type 3 diabetes? 
Absolutely. 

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Part of what's going on in the 
brain is that the brain takes up

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2% of body weight but uses 20% 
of energy expenditure every day.

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This is a very resource heavy 
organ. 

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And you know, this is part of 
why we wear a hat to stay warm, 

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right? 
That the brain is burning so 

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much fuel each day that we give 
off heat and that fuel as we 

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age. 
You know, when we're younger and

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in this day and age, we use 
sugar primarily, you know, 

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sugar, carbohydrates, glucose. 
We can use those inter 

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interchangeably. 
But most people at this stage in

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human evolution, they're burning
carbohydrates 24/7, 365 days a 

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year, Very unlike our ancestors 
who used to go through periods 

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of famine or fast, or maybe they
had meat available, they didn't 

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have carbohydrates and fruits 
available. 

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So now our we're kind of going 
against our evolutionary 

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mechanisms that really support 
healthy brain function by only 

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having carbohydrates as a fuel 
source. 

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Now as we age, regardless of our
diabetes status, we all become 

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somewhat insulin resistant. 
This means that the the peptide,

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the molecule that we use or the 
molecules that the string of 

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amino acids that get used as the
signal to allow glucose, 

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carbohydrate, sugar to go from 
the bloodstream into the cell, 

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whether turned into ATP or the 
fuel that our cells run on, the 

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mechanism that allows for that 
via insulin gets kind of sticky.

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I think of it like a key that's 
been copied too many times. 

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If we have too much insulin 
showing up in the bloodstream, 

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it actually has its own 
inflammatory ramifications, but 

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it also doesn't allow that sugar
to get into the cell. 

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Now, even if that sugar does get
into the cell, if we've got an 

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abundant amount of it and some 
of that insulin is working, 

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we've got sugar in the cell in 
the brain. 

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And the brain doesn't turn that 
into to ATP, that currency that 

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fuel our cells run on adenosine 
triphosphate or ATP doesn't turn

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it into that as well as it used 
to. 

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Now, that's regardless of our 
diabetes status. 

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So ketones are the alternative 
fuel. 

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And I just think that the body, 
the brain has this divine 

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design. 
It just blows my mind. 

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I have such a reverence for it, 
but the genius that is this 

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ability to switch between 
different fuel sources allows us

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allowed our ancestors to 
survive, right. 

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So when we're when we're in a 
starvation mode, when we flip 

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that metabolic switch into 
ketosis, our brain actually 

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turns on. 
Now you mentioned type 3 

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diabetes. 
So if someone and this is a 

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colloquial way or like kind of a
way that will refer to 

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Alzheimer's sometimes because 
many of the Alzheimer's cases in

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this and age are caused by 
glucotoxicity or a toxic amount 

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of glucose, sugar, carbohydrates
in the bloodstream, leading to 

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essentially like a 
caramelization of the cells 

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themselves. 
But also this resource 

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inefficiency and this, this, 
it's like you run out of fuel 

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because you can't turn the 
building blocks into ATP. 

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So that brain that that organ 
that needs so much extra energy 

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that it's really seen heat 
throughout the day, I can't get 

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it. 
Even though we keep eating more 

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and more sugar in the case of 
diabetes. 

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So when it comes to the the 
insulin resistance as we age, I 

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feel like we've all heard that 
to some extent. 

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We know that we get more insulin
resistant as we get older. 

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But from a from a technical 
standpoint, is that lack of 

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insulin sensitivity coming from 
just a myriad of different 

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effects like dropping muscle 
tissue as we age, less activity 

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as we age? 
Like is there any one thing that

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is the primary culprit to that 
drop in insulin sensitivity? 

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That's a great question. 
I don't know that we have a full

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answer. 
And I think as you alluded to 

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that there's probably multiple 
mechanisms at at play there as 

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we age. 
But I think and exercise and, 

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and muscle mass being one of 
them, that metabolic flexibility

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that we get from going in and 
out of ketosis and in and out of

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glycolysis. 
So going back and forth between 

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burning sugar for fuel and 
burning ketones for fuel, that 

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allows us to maintain that 
insulin sensitivity, that 

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ability to help insulin shuttle 
glucose from the bloodstream 

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into the cell where it does the 
work. 

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And so I, I think there's 
multiple things, but being in 

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glycolysis, burning sugar for 
fuel creates a lot of oxidative 

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stress that can do direct damage
to the neurons. 

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It creates a lot of basically, 
it doesn't turn ATP into ATP as 

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efficiently as ketones. 
And it's also very toxifying, 

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right? 
It creates more toxicity, 

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oxidative stress. 
A ketogenic diet is 

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anti-inflammatory because, and 
just in comparison to a glucose 

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heavy diet, which is very pro 
inflammatory, right? 

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A ketogenic diet is very 
anti-inflammatory. 

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A ketogenic diet reduces 
toxicity by mobilizing fat. 

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A lot of fat soluble toxins are 
stored where a high glucose diet

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actually increases toxicity 
through glucose itself. 

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In that mechanism I described of
glycation or these advanced 

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glycation in products called 
AGES, which makes a lot of 

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sense. 
As we accumulate them as we age,

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we have more of them and they 
almost are literally this 

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caramelization of cells that 
prevents them from functioning. 

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And then in addition to the 
anti-inflammatory effects of 

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keto and the the detox benefits 
of keto, there's also that 

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antioxidant benefit or that 
relative reduction in oxidative 

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stress in the brain that we get 
from being in ketosis versus 

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glycolysis. 
Got you. 

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That makes no sense. 
So from like from an analogy 

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standpoint, when people are 
familiar with those that have, 

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you know, diabetes, not type 3 
diabetes, but just diabetes in 

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general and they're experiencing
neuropathy, they're having to 

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have, you know, toes amputated 
due to that glycolysin that that

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glycation in the capillary cells
in these extremities and in the 

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eyes. 
That's pretty much what is 

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happening in the brain as the 
age and that is resulting in the

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the neurogenerative diseases 
that we're familiar with like 

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the Alzheimer's dementia. 
Precisely. 

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Gotcha. 
OK. 

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So I am, I'm interested in this 
because I feel like, you know, 

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from a ketogenic standpoint, I'm
a big believer and proponent 

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that that is the optimal way 
that we should consume food as a

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species. 
And when you look at it from a 

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longevity standpoint, it just 
seems like a good insurance 

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policy. 
Like, if you want to minimize 

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the likelihood of the risk of 
you having neurodegenerative 

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disease, simply avoiding the 
excess of sugars and energy 

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toxicity in general would 
probably be the best bang for 

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the proverbial buck. 
So that's actually what I tell 

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my patients is I think, you 
know, we have this robust 

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program that includes diet and 
exercise and stress management 

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and sleep and the functional 
medicine work up of looking for 

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toxins and infections and all of
that is really important. 

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But 50% of the lift is getting 
into ketosis. 

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I just see the most profound 
benefits for people's cognition 

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for my elderly patients, 
cognition from flipping that 

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metabolic switch. 
It is like the lights come on. 

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In many cases, they start 
remembering their 

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grandchildren's names when they 
hadn't for months. 

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And so many people also share 
that they get better sleep, 

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their mood is better, they feel 
less pain because they're less 

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inflamed, their joints move 
better, and they get they feel 

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like they can walk in a 
different way and they have more

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stamina. 
They don't get that slump of 

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energy in the afternoon. 
So there's a bunch of benefits 

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that help many of the mechanisms
associated with 

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neurodegenerative decline as we 
age. 

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What was your driving factor for
getting into this line of work 

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in the 1st place? 
Did you have a grand pen or 

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something that was plagued by 
this and that was the motivation

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or what was the origin story? 
Really, it was that I had heard 

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it wasn't possible. 
I was trained by my mentor, 

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Doctor Dale Bredesen, in 2017, 
and then I was on his list of 

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providers who had been trained 
by him to see patients with 

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Alzheimer's. 
And I went to his training 

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because I was very skeptical. 
But the way he explained it, the

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mechanisms and the potential of 
stacking all of these 

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interventions on top of each 
other to support neuronal 

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health, that made conceptual 
sense to me, right. 

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If that's common sense, if we 
give cells everything they need 

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to thrive and take out all the 
junk that prevents them from 

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thriving, then we get better 
function. 

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I mean, we could apply this, 
these concepts really to any, 

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any complex system, whether it's
a plant or, you know, a child or

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an animal or, you know, even 
financial systems and government

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systems. 
We need balance. 

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We need homeodynamic balance in 
them. 

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And it's not about a one, a 
single molecule intervention or 

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one pill or one IV that's going 
to help with this disease. 

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And so I, I got that 
conceptually, but I was very, 

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very skeptical. 
Well, then Fast forward to me 

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seeing patients in my office 
that they had way more, way more

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confidence in the process than I
did because I hadn't seen it 

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work, right? 
I needed to see it work to be as

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confident as some of these 
patients were. 

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And Doctor Bredesen was. 
But I did, I saw it work over 

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and over and over again. 
And as a provider, as a medical 

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provider, when you you see 
something like that happening 

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before your eyes, like the 
impossible is happening and 

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people are getting better. 
They're getting their lives 

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back. 
They're getting their parents 

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back and their spouses back. 
And they get that one more 

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Christmas, so that one more 
anniversary or that summer where

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they're really fully engaged and
present and participating in the

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relationships that is. 
I mean, there was just no way I 

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could do anything else with my 
life, right? 

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It's like people were still, I 
still have patients coming in 

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saying the neurologist told me 
to get my affairs in order. 

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There's a couple of medications 
that don't work very well. 

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They might slow the progression,
but he's got to take my driver's

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license away and he'll see me in
6 to 12 months to see how much 

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worse I am, basically. 
And that is such a hopeless 

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message and it's the reality on 
the conventional side. 

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And yet there's so much that we 
can do. 

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And watching patients take 
control back of their own 

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health, of their brain health, 
seeing how empowered they are, 

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seeing how hopeful they are, 
seeing the work that they put in

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and how dedicated they are to 
each other. 

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I often see families that have, 
you know, support through 

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multiple generations to put this
plan into action. 

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And it's just so inspiring and 
meaningful. 

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And, and I'm very motivated to 
get out of bed in the morning 

229
00:12:20,600 --> 00:12:22,400
because I have the privilege 
doing this. 

230
00:12:22,600 --> 00:12:24,680
No, I, I love it. 
There's, there's very few things

231
00:12:24,680 --> 00:12:26,360
I can think of that'd be more 
fulfilling with that. 

232
00:12:26,360 --> 00:12:29,840
I mean, that's, that's you're 
seeing people regain that spark 

233
00:12:29,840 --> 00:12:31,600
and they're like, what, what? 
What can be better than that? 

234
00:12:32,640 --> 00:12:36,720
Yeah, talking, excuse me, just 
talking to elderly patients the 

235
00:12:36,720 --> 00:12:39,760
way I get to, I often will ask, 
you know, what are your happiest

236
00:12:39,760 --> 00:12:43,040
memories? 
What are what are you most proud

237
00:12:43,040 --> 00:12:45,960
of? 
And it's 9 out of 10 times and 

238
00:12:45,960 --> 00:12:48,040
probably more than that, it's 
the connections. 

239
00:12:48,040 --> 00:12:50,800
It's the, it's those 
relationships with the people 

240
00:12:50,800 --> 00:12:52,640
that they love. 
That's what it's about. 

241
00:12:52,640 --> 00:12:55,240
And if we can be present for 
those, if we can participate in 

242
00:12:55,240 --> 00:12:58,760
those longer, that is is just 
priceless. 

243
00:12:59,000 --> 00:13:00,640
Yeah, I completely, completely 
agree. 

244
00:13:01,080 --> 00:13:04,760
I feel like there is. 
So I want to learn about your, 

245
00:13:04,760 --> 00:13:05,920
your, your practice, your 
clinic. 

246
00:13:05,920 --> 00:13:07,880
I want, I want to dive into that
and it's going to frame my next 

247
00:13:07,880 --> 00:13:10,360
question. 
So who is your target 

248
00:13:10,360 --> 00:13:12,440
demographic? 
I'm assuming the elderly that 

249
00:13:12,440 --> 00:13:15,720
have been already diagnosed with
a neurodegenerate disease. 

250
00:13:17,000 --> 00:13:19,920
So my very favorite is to see 
multiple generations in the same

251
00:13:19,920 --> 00:13:21,960
family because they cheer each 
other on. 

252
00:13:22,200 --> 00:13:24,920
They all get it. 
They're all on the same page. 

253
00:13:25,160 --> 00:13:26,560
They hold each other 
accountable. 

254
00:13:26,560 --> 00:13:30,480
They eat the same diet. 
So I often will start by seeing 

255
00:13:30,480 --> 00:13:32,800
the person who's been diagnosed 
with dementia in the family. 

256
00:13:32,920 --> 00:13:36,280
And then typically, you know, 
and especially when things go 

257
00:13:36,280 --> 00:13:39,480
well and it it feels doable, 
then I start seeing the daughter

258
00:13:39,720 --> 00:13:42,400
or the spouse. 
And then I start seeing the 

259
00:13:42,400 --> 00:13:44,920
grandkids who might be in their 
20s or 30s. 

260
00:13:45,280 --> 00:13:48,800
And that is really, really fun 
because then everyone's in 

261
00:13:48,800 --> 00:13:54,000
alignment and I see even better 
results with patients who have 

262
00:13:54,000 --> 00:13:56,800
come with that, that support 
system. 

263
00:13:58,080 --> 00:13:59,920
And so, yeah, that's my my 
favorite. 

264
00:13:59,920 --> 00:14:02,520
It's when we get to, it's really
a luxury when we're in the 

265
00:14:02,520 --> 00:14:04,840
prevention phase and we might 
know that somebody's APOE 

266
00:14:04,880 --> 00:14:10,400
status, APOEAPOE, if you have 
one or two copies of APOE 4, 

267
00:14:10,720 --> 00:14:13,280
that can put you at higher risk 
for developing dementia over 

268
00:14:13,280 --> 00:14:17,160
time. 
And so when we know that in our 

269
00:14:17,160 --> 00:14:20,440
20s, thirties, we can, I mean it
for me as a provider, it's just 

270
00:14:20,440 --> 00:14:22,120
such a luxury. 
We can look for all of the 

271
00:14:22,120 --> 00:14:25,520
potential risk factors, all the 
causal level factors, and we can

272
00:14:25,520 --> 00:14:28,760
eliminate them so that again, we
can delay, prevent and 

273
00:14:29,240 --> 00:14:31,760
Alzheimer's from ever taking 
hold, hopefully. 

274
00:14:32,080 --> 00:14:35,880
And then in the later stages, 
some people might be starting. 

275
00:14:36,200 --> 00:14:38,600
Sometimes I'll see patients 
where they're like my brain, 

276
00:14:38,840 --> 00:14:41,960
especially postmenopausal women 
or kind of perimenopausal women 

277
00:14:42,720 --> 00:14:45,600
where their brain isn't working 
the way it used to, right? 

278
00:14:45,600 --> 00:14:47,920
They're, they're feeling more 
overwhelmed by hosting 

279
00:14:47,920 --> 00:14:50,840
Thanksgiving or planning an 
international trip. 

280
00:14:51,240 --> 00:14:54,040
They just don't feel like they 
can take on what they used to. 

281
00:14:54,040 --> 00:14:57,800
They're confused more easily and
they have maybe some brain fog. 

282
00:14:57,800 --> 00:15:00,760
They're not sleeping as well. 
And potentially a family history

283
00:15:00,760 --> 00:15:02,520
of Alzheimer's. 
And they, they remember, oh, 

284
00:15:02,520 --> 00:15:05,920
mom, this is where it started. 
She never really recovered after

285
00:15:05,920 --> 00:15:07,520
menopause. 
It started to go downhill. 

286
00:15:07,920 --> 00:15:10,320
And that's a great time to work 
with someone as well, because 

287
00:15:11,160 --> 00:15:14,560
those earlier stages, we have 
the most confidence that we can 

288
00:15:14,560 --> 00:15:17,560
get reversal, and it happens the
quickest with the least amount 

289
00:15:17,560 --> 00:15:19,440
of effort. 
Now, when I'm working with 

290
00:15:19,440 --> 00:15:22,000
people in later stages of 
Alzheimer's, there's no 

291
00:15:22,000 --> 00:15:24,320
guarantee that they're going to 
get improvement. 

292
00:15:24,400 --> 00:15:28,240
But often we do see improvements
even for people with severe 

293
00:15:28,240 --> 00:15:31,120
Alzheimer's. 
In that case, it's rare that 

294
00:15:31,120 --> 00:15:34,680
someone, I've never seen someone
go from severe Alzheimer's to 

295
00:15:34,680 --> 00:15:36,280
fully recovered and back to 
work. 

296
00:15:36,600 --> 00:15:39,960
I've seen them improve, maybe 
regain verbal ability, regain 

297
00:15:39,960 --> 00:15:43,720
the ability to engage in 
activities of daily living, get 

298
00:15:44,360 --> 00:15:48,040
enjoy life more right and be 
able to converse with people 

299
00:15:48,040 --> 00:15:52,280
more fluently. 
Those that's very common and we 

300
00:15:52,280 --> 00:15:56,480
see that a lot, but it's harder.
It requires a lot more effort, 

301
00:15:56,480 --> 00:15:59,400
energy and resources when 
someone's more in that severe 

302
00:15:59,400 --> 00:16:01,600
state. 
But we see people across that 

303
00:16:01,600 --> 00:16:05,160
spectrum. 
So when it comes to you 

304
00:16:05,160 --> 00:16:07,760
mentioned that the menopausal 
year, I've had several guests on

305
00:16:07,760 --> 00:16:11,600
the podcast talking about that 
as a pertains to hormone 

306
00:16:11,600 --> 00:16:15,200
regulation. 
And it seems as though the push 

307
00:16:15,200 --> 00:16:19,720
towards exogenous hormones, HRT 
during that time is is the, is 

308
00:16:19,720 --> 00:16:23,280
the prevailing modality that is 
gaining traction. 

309
00:16:23,920 --> 00:16:27,120
A lot of it is for, you know, 
the the disease prevention as 

310
00:16:27,120 --> 00:16:28,720
well, like increasing bone 
density. 

311
00:16:29,280 --> 00:16:34,280
Have you noticed anything as it 
pertains to that and how it 

312
00:16:34,680 --> 00:16:38,880
relates to neurodegenerative 
decline or lack thereof? 

313
00:16:38,880 --> 00:16:43,640
Is there an argument to be made 
there in the benefits of HRT for

314
00:16:43,640 --> 00:16:46,000
brain health? 
Absolutely. 

315
00:16:46,000 --> 00:16:48,800
Yeah. 
So what my clinical experience 

316
00:16:48,800 --> 00:16:55,400
is that women who get on HRT it 
what it feels like watching a 

317
00:16:55,400 --> 00:16:59,080
flower go from being like wilted
to getting water and perking 

318
00:16:59,080 --> 00:17:02,680
back up. 
It's just, it's so fun to see 

319
00:17:02,920 --> 00:17:05,319
and not for everyone, not 
everybody can tolerate it. 

320
00:17:05,640 --> 00:17:09,920
But there was a very validating 
research study that was 

321
00:17:09,920 --> 00:17:12,560
published in May of 2024, very 
recently. 

322
00:17:12,880 --> 00:17:18,480
And it took 11,000,000 Medicare 
aged women, so 65 and older, one

323
00:17:18,480 --> 00:17:22,000
and a half million who were on 
HRT and nine and a half million 

324
00:17:22,000 --> 00:17:23,680
who were not. 
So after the Women's Health 

325
00:17:23,680 --> 00:17:27,040
Initiative study was published 
in, in the early 2000s, many 

326
00:17:27,040 --> 00:17:31,120
women become very fearful, many 
doctors became very fearful of 

327
00:17:31,120 --> 00:17:33,760
using HRT, hormone replacement 
therapy. 

328
00:17:34,240 --> 00:17:38,800
Now the, you know, when we look 
back, that really was a failure 

329
00:17:39,480 --> 00:17:43,520
of research, medicine and the 
media in terms of telling women 

330
00:17:43,520 --> 00:17:46,200
that it wasn't safe to take 
hormone replacement. 

331
00:17:46,480 --> 00:17:49,560
There are, you don't want to 
take oral estrogen, you want 

332
00:17:49,560 --> 00:17:51,960
estrogen that's topical or 
vaginal. 

333
00:17:52,320 --> 00:17:57,000
And that is associated with 
profound reduction in risk, 

334
00:17:57,280 --> 00:18:01,000
reduction in, in all 'cause 
mortality reduction and dementia

335
00:18:01,000 --> 00:18:03,600
rates, reduction in breast 
cancer rates, colon cancer 

336
00:18:03,600 --> 00:18:07,520
rates, heart disease, the list 
goes on and on of and of course,

337
00:18:07,520 --> 00:18:10,400
you mentioned bone density and 
and osteoporosis risk. 

338
00:18:11,800 --> 00:18:17,320
I think that there's no question
anymore that thoughtful hormone 

339
00:18:17,320 --> 00:18:21,960
replacement makes a ton of sense
for health risk reduction as we 

340
00:18:21,960 --> 00:18:23,080
age. 
Gotcha. 

341
00:18:23,080 --> 00:18:26,000
OK, that makes sense. 
I've, I've been tackling that, 

342
00:18:26,080 --> 00:18:28,400
that question because I get that
question a lot and I'm not 

343
00:18:28,400 --> 00:18:31,200
qualified to answer because I'm 
not a menopausal woman going 

344
00:18:31,200 --> 00:18:35,040
through HRT therapy. 
But I feel like there is a lot 

345
00:18:35,040 --> 00:18:37,000
of science coming out. 
There was a lot of you know, as 

346
00:18:37,000 --> 00:18:39,520
you mentioned that the the 
poorly designed studies in the 

347
00:18:39,520 --> 00:18:42,600
early 2000s and I feel like that
swaying people. 

348
00:18:42,600 --> 00:18:45,440
I feel like that the the new 
information is certainly 

349
00:18:45,840 --> 00:18:50,280
surfacing now, which is great. 
I'm definitely curious to see 

350
00:18:50,280 --> 00:18:53,200
what the, you know, long term 
outcome is. 

351
00:18:53,920 --> 00:18:56,120
But I feel like it's pretty hard
to argue a lot of the benefits 

352
00:18:56,120 --> 00:18:58,720
that have come with the HRT if 
done correctly. 

353
00:18:58,720 --> 00:19:01,680
As long as everybody's got all 
the other environmental 

354
00:19:01,680 --> 00:19:04,680
lifestyle factors in place. 
I always sway people against 

355
00:19:05,080 --> 00:19:11,360
going to HRT route as the first,
you know, first way to avoid any

356
00:19:11,400 --> 00:19:12,960
adverse effects. 
But if you've got everything 

357
00:19:12,960 --> 00:19:14,840
else started in, then it becomes
a viable option. 

358
00:19:15,720 --> 00:19:19,160
Well, you know what, I I would 
really urge you to read this 

359
00:19:19,160 --> 00:19:20,920
paper. 
I'm happy to send the link along

360
00:19:20,920 --> 00:19:23,920
and we can put it in the show 
notes, but I, I don't think you 

361
00:19:23,920 --> 00:19:26,320
have to talk people out of HRT 
anymore. 

362
00:19:26,520 --> 00:19:31,160
We have this trial again, 
11,000,000 women who were over 

363
00:19:31,160 --> 00:19:33,840
the age of 65. 
SA lot of the caution was OK get

364
00:19:33,840 --> 00:19:37,200
on HRT to prevent the hot 
flashes while you're going 

365
00:19:37,200 --> 00:19:39,640
through menopause and then get 
off of it as quickly as 

366
00:19:39,640 --> 00:19:41,600
possible. 
It's not safe to safe to stay on

367
00:19:41,600 --> 00:19:44,720
it, but this attracts women over
20 years. 

368
00:19:45,000 --> 00:19:48,920
So there is long term data. 
There is a ton of data and 

369
00:19:48,920 --> 00:19:52,400
overwhelmingly it suggests that 
there are many, many, many 

370
00:19:52,400 --> 00:19:54,920
health benefits to being on 
hormone replacement. 

371
00:19:55,320 --> 00:19:59,080
So I or hormone therapy. 
So I I get your caution. 

372
00:19:59,080 --> 00:20:02,640
I was also very cautious for a 
long time and we were and 

373
00:20:02,640 --> 00:20:05,280
clinically we would use it. 
You know, women were comfortable

374
00:20:05,280 --> 00:20:07,240
with it if they had no breast 
cancer history risk. 

375
00:20:07,240 --> 00:20:10,200
We were obviously looking at 
mammograms and we'll continue to

376
00:20:10,200 --> 00:20:12,120
do that to mitigate the risk 
because there. 

377
00:20:12,200 --> 00:20:16,680
It is risk if you have a cancer 
present and it is estrogen 

378
00:20:17,280 --> 00:20:20,400
receptor positive, so like a 
breast cancer, ovarian cancer, 

379
00:20:21,240 --> 00:20:24,600
potentially uterine cancer, but 
you should be on progesterone if

380
00:20:24,600 --> 00:20:27,840
you have a uterus or if you have
a progesterone receptor positive

381
00:20:27,840 --> 00:20:31,200
cancer, it will go grow faster 
in the presence of these 

382
00:20:31,200 --> 00:20:33,320
hormones. 
So that's the reason to 

383
00:20:33,320 --> 00:20:36,680
restrict. 
But you know, breast cancer, you

384
00:20:36,680 --> 00:20:40,280
reduce the risk of getting 
breast cancer when you're on 

385
00:20:40,440 --> 00:20:43,920
hormone therapy. 
So I hear, I hear the caution 

386
00:20:43,920 --> 00:20:46,960
and that had the cautionary tale
has been told for many, many, 

387
00:20:46,960 --> 00:20:50,040
many years. 
I fully appreciate why, but I 

388
00:20:50,040 --> 00:20:51,880
think we can put that to rest 
now. 

389
00:20:52,280 --> 00:20:55,400
It is beneficial for women to be
on hormone therapy. 

390
00:20:55,640 --> 00:20:56,760
What about males? 
What? 

391
00:20:56,760 --> 00:20:59,440
What do we know from an 
Alzheimer's dementia standpoint 

392
00:20:59,600 --> 00:21:03,480
as it pertains to males on or 
off HRT? 

393
00:21:04,160 --> 00:21:07,360
Yeah, there is great data 
suggesting that testosterone 

394
00:21:07,360 --> 00:21:10,960
therapy in both men and women 
helps to prevent dementia and 

395
00:21:10,960 --> 00:21:13,440
Alzheimer's. 
And what is what is the the 

396
00:21:13,440 --> 00:21:16,960
primary mechanism of action 
there as it pertains to the 

397
00:21:16,960 --> 00:21:18,600
neurological component? 
Like what? 

398
00:21:18,600 --> 00:21:21,280
What is the what? 
What hormones are taking place 

399
00:21:21,280 --> 00:21:24,360
that are causing preservation of
cognition? 

400
00:21:24,960 --> 00:21:27,480
Yeah, great question. 
So testosterone as we know helps

401
00:21:27,480 --> 00:21:32,800
with muscle building and muscle 
itself sends BDNF brain derived,

402
00:21:32,800 --> 00:21:36,160
no trophic factor to the brain. 
So you've probably heard of 

403
00:21:36,160 --> 00:21:40,640
these maybe as extra kinds or 
you've heard that muscle is more

404
00:21:40,640 --> 00:21:43,400
of an endocrine organ than just 
connective tissue. 

405
00:21:43,520 --> 00:21:46,240
When I was in medical school, we
called it, we just classified it

406
00:21:46,240 --> 00:21:48,480
as connective tissue. 
And now as the research has 

407
00:21:48,720 --> 00:21:53,120
evolved, we know that muscle 
itself is sending signals around

408
00:21:53,120 --> 00:21:55,920
the body that are health 
promoting, including brain 

409
00:21:55,920 --> 00:21:58,760
dreadnatrophic factor, which 
goes to the brain and supports 

410
00:21:58,760 --> 00:22:02,240
neurogenesis and synaptogenesis.
That's the creation of new 

411
00:22:02,240 --> 00:22:05,280
neurons and the creation of 
connections between them. 

412
00:22:05,760 --> 00:22:09,880
And also testosterone itself has
receptor sites in the brain. 

413
00:22:09,880 --> 00:22:13,960
If you think back to when you're
in your early 20 or yeah, early 

414
00:22:13,960 --> 00:22:17,240
20s, late teens, this is when 
our sex hormones are peaking, 

415
00:22:17,280 --> 00:22:19,040
right? 
We're like gone through puberty.

416
00:22:19,040 --> 00:22:22,240
And we're also in college, 
right? 

417
00:22:22,240 --> 00:22:24,040
We're making all these social 
connections. 

418
00:22:24,040 --> 00:22:26,640
We're we're building skills, 
we're learning. 

419
00:22:26,640 --> 00:22:30,880
We're sort of at that peak of 
that ability to learn and 

420
00:22:30,880 --> 00:22:33,480
conceptualize and take on new 
ideas. 

421
00:22:33,480 --> 00:22:37,120
We're really open to new ideas 
and a lot of that is sex hormone

422
00:22:37,120 --> 00:22:39,280
signaling. 
And so we don't necessarily need

423
00:22:39,280 --> 00:22:42,840
people in their 70s to go back 
to feeling like they're 19 

424
00:22:42,840 --> 00:22:45,640
again. 
That can be, you know, it 

425
00:22:45,640 --> 00:22:49,480
involves libido and distractions
in that in that arena. 

426
00:22:49,800 --> 00:22:53,320
So we don't necessarily have to 
go to that high of dosing. 

427
00:22:53,680 --> 00:22:56,360
But even, and in that paper that
I was referring to that was 

428
00:22:56,360 --> 00:23:01,400
published in May, low to medium 
doses are the most beneficial. 

429
00:23:01,400 --> 00:23:04,880
So we want enough signaling of 
the sex hormones, but also 

430
00:23:04,880 --> 00:23:06,960
stress hormones right there, 
lots of hormones. 

431
00:23:06,960 --> 00:23:10,320
We want the right amounts in the
right place at the right time. 

432
00:23:10,600 --> 00:23:13,640
So getting some testosterone, 
estrogen, progesterone, 

433
00:23:13,640 --> 00:23:19,240
pregnenolone, DHEA, but also 
vitamin D, vitamin K, BDNF, 

434
00:23:19,440 --> 00:23:21,880
thyroid hormone. 
All of these hormones have 

435
00:23:21,880 --> 00:23:26,960
receptor sites in the brain that
put the brain in going in the 

436
00:23:26,960 --> 00:23:33,400
direction of repair, remodel, 
regenerate, create, grow new and

437
00:23:33,680 --> 00:23:38,880
they get it out of that that 
defend, attack, shrink, get 

438
00:23:38,880 --> 00:23:41,960
smaller state, right. 
So we want to be oriented 

439
00:23:41,960 --> 00:23:45,680
towards that regenerative state 
and away from the shrinking 

440
00:23:45,680 --> 00:23:48,400
atrophy state. 
Totally, What are some other 

441
00:23:48,400 --> 00:23:51,200
lifestyle design factors that 
one can implement apart from the

442
00:23:51,200 --> 00:23:53,120
HRT? 
Obviously we talked about the 

443
00:23:53,120 --> 00:23:55,920
ketogenic diet, but anything 
else come to mind is like low 

444
00:23:55,920 --> 00:24:00,160
hanging fruit to implement to 
preserve cognition and overall 

445
00:24:00,320 --> 00:24:03,040
psychological health. 
This is my favorite question. 

446
00:24:03,040 --> 00:24:05,480
Thank you so much for the 
opportunity to kind of just zoom

447
00:24:05,480 --> 00:24:07,640
out. 
Okay, what are what are some of 

448
00:24:07,640 --> 00:24:10,560
the other factors? 
And this is a precision based 

449
00:24:10,560 --> 00:24:13,480
approach, right? 
So I've talked about balance. 

450
00:24:13,480 --> 00:24:16,320
So when homeodynamic balance, 
when we think about the brain, 

451
00:24:17,200 --> 00:24:19,520
we want to think through all of 
the things that might get out of

452
00:24:19,520 --> 00:24:23,520
balance and at a causal level 
cause neurodegeneration or set 

453
00:24:23,520 --> 00:24:26,000
off, you know, and some people 
will say, oh, inflammation is 

454
00:24:26,000 --> 00:24:29,120
the cause of Alzheimer's. 
No, inflammation is the 

455
00:24:29,120 --> 00:24:32,080
downstream effect of something 
else that is the cause. 

456
00:24:32,400 --> 00:24:35,080
Same thing with amyloid plaques 
or Tau proteins. 

457
00:24:35,400 --> 00:24:37,680
Misfolded proteins. 
If you have a plant, right, that

458
00:24:37,680 --> 00:24:40,360
you're trying to keep alive in 
your house, if it starts to wilt

459
00:24:40,360 --> 00:24:42,800
and droop and turn brown, you 
don't go, oh, there must be 

460
00:24:42,800 --> 00:24:44,600
misfolded proteins, let's get 
them out. 

461
00:24:44,840 --> 00:24:46,600
You think to yourself, is it 
getting enough water? 

462
00:24:46,600 --> 00:24:49,160
Is it getting enough sunlight? 
Is it getting enough nutrients? 

463
00:24:49,320 --> 00:24:53,040
Are there toxins in the soil? 
Is it, does it have too much 

464
00:24:53,040 --> 00:24:53,600
water? 
Right. 

465
00:24:53,600 --> 00:24:57,680
So we want homeodynamic balance,
the right amounts in the right 

466
00:24:57,680 --> 00:25:00,040
place at the right time in the 
brain. 

467
00:25:00,560 --> 00:25:03,560
And the there's six components 
of brain health. 

468
00:25:03,560 --> 00:25:05,000
And I'm going to double click on
sleep. 

469
00:25:05,000 --> 00:25:08,880
But first I want to give us a, a
framework for where this goes. 

470
00:25:09,240 --> 00:25:12,160
So number one is toxicity. 
And we talked about how glucose 

471
00:25:12,160 --> 00:25:15,800
can be become toxic and that's, 
that's basically too much of A 

472
00:25:15,800 --> 00:25:19,080
nutrient, right? 
But toxins also can come from 

473
00:25:19,080 --> 00:25:23,400
the environment, mold, toxins, 
metals, also chemical toxicity. 

474
00:25:23,520 --> 00:25:26,400
And so we look for that, 
particularly as we age, we 

475
00:25:26,400 --> 00:25:28,560
accumulate toxins. 
We want to keep our organs of 

476
00:25:28,560 --> 00:25:30,600
elimination open. 
That means having a bowel 

477
00:25:30,600 --> 00:25:33,160
movement every day, drinking 
plenty of good clean filtered 

478
00:25:33,160 --> 00:25:37,840
water, means sweating regularly,
means maybe some lung detox, 

479
00:25:37,840 --> 00:25:41,120
breath work and some liver 
support supporting our organs of

480
00:25:41,120 --> 00:25:43,320
elimination. 
So that the natural toxins that 

481
00:25:43,320 --> 00:25:46,200
we have from metabolic, which is
the metabolic waste all of our 

482
00:25:46,200 --> 00:25:49,640
cells create each day, but also 
the toxins that we're exposed to

483
00:25:49,640 --> 00:25:52,200
in a frankly toxic world. 
We need to be able to get rid of

484
00:25:52,200 --> 00:25:55,880
those and eliminate them so they
don't cause disease over over 

485
00:25:55,880 --> 00:25:57,840
the course of our lives. 
And then nutrients. 

486
00:25:58,080 --> 00:26:01,600
We talked about a macro nutrient
or, or a couple, right, fats and

487
00:26:01,600 --> 00:26:03,760
sugars, but there's also 
protein. 

488
00:26:03,760 --> 00:26:07,400
And then there's micronutrients.
Do we have enough methylated B12

489
00:26:07,400 --> 00:26:10,480
to keep our homocysteine down? 
Elevated levels of homocysteine 

490
00:26:10,480 --> 00:26:14,240
are associated with brain 
atrophy, but also carnitine and 

491
00:26:14,240 --> 00:26:18,080
creatine. 
And there's so many, I'm, I'm 

492
00:26:18,120 --> 00:26:20,720
just said a phosphatl serine and
phosphatl choline. 

493
00:26:21,080 --> 00:26:23,840
There enough omegas. 
There are lots of 

494
00:26:23,840 --> 00:26:27,560
micronutrients, aminos, those 
minerals, vitamins, antioxidants

495
00:26:27,880 --> 00:26:30,840
that we want to understand, are 
we not only are we eating the 

496
00:26:30,840 --> 00:26:33,720
right things, but can we then 
digest and absorb them? 

497
00:26:33,720 --> 00:26:35,840
And can we eliminate what 
doesn't serve us so that we have

498
00:26:35,840 --> 00:26:38,280
a good healthy microbiome that's
supporting our brain health? 

499
00:26:38,640 --> 00:26:41,840
So toxins and nutrients and 
nutrients kind of thinking 

500
00:26:41,840 --> 00:26:44,120
through not only what are we 
eating, but can we absorb them 

501
00:26:44,160 --> 00:26:49,000
and macro and micronutrients and
then structure stressors, 

502
00:26:49,320 --> 00:26:50,920
signaling. 
We talked about hormones, 

503
00:26:50,920 --> 00:26:52,520
signaling is a really big 
component. 

504
00:26:52,600 --> 00:26:55,480
And then the 6th component is 
infections. 

505
00:26:55,680 --> 00:27:01,120
So again, those six are toxins, 
nutrients, stressors, structure 

506
00:27:01,480 --> 00:27:05,120
signaling and infections. 
The way the place I want to 

507
00:27:05,120 --> 00:27:08,720
double click is on structure 
because sleep apnea, the 

508
00:27:08,720 --> 00:27:14,200
obstruction of the airway at 
night is a huge culprit in 

509
00:27:14,440 --> 00:27:18,000
cognitive decline as we age. 
And many people who I've seen, 

510
00:27:18,000 --> 00:27:22,160
especially my little old ladies 
who maybe they have a partner 

511
00:27:22,160 --> 00:27:24,600
who wears hearing aids and takes
them out at night or they don't 

512
00:27:24,600 --> 00:27:27,280
have a partner anymore who would
know that they're snoring. 

513
00:27:27,600 --> 00:27:28,880
So we don't know they're 
snoring. 

514
00:27:28,920 --> 00:27:34,320
They're thin and they are not 
the classic obese male who you 

515
00:27:34,320 --> 00:27:35,920
would imagine is snoring at 
night. 

516
00:27:35,920 --> 00:27:40,160
And we catch the sleep apnea. 
They're women who don't fit the 

517
00:27:40,320 --> 00:27:43,680
stereotypical sleep apnea, a 
patient and sure enough, when we

518
00:27:43,680 --> 00:27:46,680
test, they have severe 
obstructive sleep apnea that is 

519
00:27:46,680 --> 00:27:49,440
contributing significantly to 
their cognitive decline. 

520
00:27:49,800 --> 00:27:53,360
And when we treat it, their 
cognition improves also, mood 

521
00:27:53,360 --> 00:27:55,440
improves, right? 
Energy improves, of course, when

522
00:27:55,440 --> 00:27:58,560
you start getting better sleep. 
But for everyone listening, 

523
00:27:59,120 --> 00:28:02,320
ideally, you know, and I, I 
don't want you to lose sleep 

524
00:28:02,320 --> 00:28:04,760
over these numbers, but I want 
to just give you some 

525
00:28:04,760 --> 00:28:07,560
guidelines. 
Ideally, you want to get at 

526
00:28:07,560 --> 00:28:10,200
least 7 hours of sleep. 
And, and you'll know, like I'm 

527
00:28:10,200 --> 00:28:12,600
someone who needs 8 1/2. 
If I get less than that, I'm not

528
00:28:12,600 --> 00:28:15,880
functioning on all cylinders. 
But, and some people, maybe they

529
00:28:15,880 --> 00:28:19,680
say, oh, I need 6 1/2. 
Like OK in that ballpark, but 

530
00:28:19,720 --> 00:28:23,480
usually a minimum for most 
people of seven hours of sleep 

531
00:28:23,480 --> 00:28:27,240
per night, 90 minutes of R.E.M. 
and at least 60 minutes of deep 

532
00:28:27,240 --> 00:28:29,200
sleep. 
I use an aura ring to track. 

533
00:28:29,400 --> 00:28:32,640
There's lots of other devices 
out there, but looking at that 

534
00:28:32,640 --> 00:28:37,000
and knowing are you getting 
enough quality, restful, 

535
00:28:37,000 --> 00:28:39,600
restorative sleep? 
The best question You know you 

536
00:28:39,600 --> 00:28:42,280
don't need any gadgets to to 
test this really. 

537
00:28:42,680 --> 00:28:44,720
Do you wake up rested in the 
morning? 

538
00:28:45,080 --> 00:28:48,480
If you can say yes the vast 
majority of the time I do, then 

539
00:28:48,480 --> 00:28:49,960
great, you're probably in good 
shape. 

540
00:28:50,240 --> 00:28:52,760
But if you have any cognitive 
decline and there's any 

541
00:28:52,760 --> 00:28:55,800
indication that you're not 
sleeping well, I recommend 

542
00:28:55,800 --> 00:28:58,600
treating it aggressively. 
I used to wait for someone to 

543
00:28:58,600 --> 00:29:01,760
tell me they were tired during 
the day or that they snored to 

544
00:29:01,760 --> 00:29:05,040
order a sleep study, and now I 
do it for every single patient 

545
00:29:05,040 --> 00:29:08,240
with any cognitive decline. 
And how do you go about 

546
00:29:08,240 --> 00:29:12,080
treatments like those, those 
older, small petite women? 

547
00:29:12,440 --> 00:29:14,320
How are you treating that sleep 
apnea? 

548
00:29:14,800 --> 00:29:16,720
Great question because a lot of 
people say, oh, don't even 

549
00:29:16,720 --> 00:29:19,000
bother testing me because I'm 
not going to wear a CPAP. 

550
00:29:19,280 --> 00:29:22,440
So there's a spectrum of 
interventions with mild sleep 

551
00:29:22,440 --> 00:29:24,240
apnea. 
Mouse tape works. 

552
00:29:24,280 --> 00:29:27,320
You can treat mild sleep apnea 
with mouth tape and sometimes 

553
00:29:27,320 --> 00:29:29,000
that will actually help to 
resolve it. 

554
00:29:29,240 --> 00:29:32,760
Now getting into ketosis helps 
with weight management often and

555
00:29:32,760 --> 00:29:35,120
that can help with apnea, but 
not all the time. 

556
00:29:35,680 --> 00:29:37,920
Somebody has more moderate or 
severe apnea. 

557
00:29:38,400 --> 00:29:41,400
There are Cpaps, but there's 
also Apaps. 

558
00:29:41,400 --> 00:29:43,720
There's the pillow, there's the 
travel version. 

559
00:29:43,960 --> 00:29:48,600
There are many many different 
types of apnea treating devices 

560
00:29:48,920 --> 00:29:50,920
and I would recommend going 
through them. 

561
00:29:50,920 --> 00:29:55,600
It's a chore but it is so well 
worth it to have your cognition 

562
00:29:55,600 --> 00:29:58,520
back. 
And if it's that simple, this is

563
00:29:58,520 --> 00:30:01,480
covered by Medicare, covered by 
insurance to get a sleep study 

564
00:30:01,480 --> 00:30:04,760
and then try work through those 
different devices. 

565
00:30:05,000 --> 00:30:09,520
You can also see a dental 
specialists who can help to fit 

566
00:30:09,520 --> 00:30:12,840
mouth guards for to, to keep the
airway open. 

567
00:30:13,200 --> 00:30:15,880
There's all kinds of little 
devices you can find, you know, 

568
00:30:16,120 --> 00:30:21,000
online, a lot of like the tennis
balls and the vest that doesn't 

569
00:30:21,000 --> 00:30:23,800
tend to work, but there are some
pillows that can help. 

570
00:30:24,160 --> 00:30:26,560
And there are also Sleep 
Medicine doctors who are totally

571
00:30:26,560 --> 00:30:29,240
dedicated to helping you make 
friends with your CPAP because 

572
00:30:29,240 --> 00:30:33,040
sometimes it's claustrophobic at
first or the the sound keeps you

573
00:30:33,040 --> 00:30:35,360
up. 
But for many people, they find a

574
00:30:35,360 --> 00:30:38,920
solution and it's it's just 
crucial you you have to get good

575
00:30:38,920 --> 00:30:41,760
high quality, restful sleep in 
order to have brain health as 

576
00:30:41,760 --> 00:30:45,720
you age. 
So I I'm AI am a self-proclaimed

577
00:30:46,280 --> 00:30:48,080
workaholic. 
I don't sleep near as much as I 

578
00:30:48,080 --> 00:30:49,440
should. 
I know that's my downfall. 

579
00:30:49,440 --> 00:30:53,080
Like I when I'm going to prep 
like I'm averaging like 3 or 4 

580
00:30:53,080 --> 00:30:56,440
hours a night. 
Like it's not good and I've been

581
00:30:56,440 --> 00:31:00,400
trying to sleep significantly 
more since that preps concluded 

582
00:31:01,240 --> 00:31:04,040
but I still have a like I still 
snore from time to time. 

583
00:31:04,040 --> 00:31:07,480
According to my wife at least, 
and I do wake up tired. 

584
00:31:07,480 --> 00:31:10,000
I think it's a lot loudly 
because just a lot of stress. 

585
00:31:10,280 --> 00:31:13,560
But I do like the mouth taping. 
I have like a an eye cover. 

586
00:31:13,560 --> 00:31:16,320
I do blackout curtains that turn
the thermostat way down. 

587
00:31:16,320 --> 00:31:18,040
Like I do all the things you're 
supposed to do. 

588
00:31:18,040 --> 00:31:20,760
But I'm thinking about just 
going all in and buying a sleep 

589
00:31:20,760 --> 00:31:24,840
AB or one of those devices CPAP 
and then just rocking that and I

590
00:31:24,840 --> 00:31:28,440
don't care how I look. 
Oh, Robert, I am so glad we're 

591
00:31:28,440 --> 00:31:31,040
having this conversation. 
This is critical. 

592
00:31:31,840 --> 00:31:33,960
And with stress, you know, 
there's lots of things that we 

593
00:31:33,960 --> 00:31:36,200
can talk about with sleep 
because people will hear me say 

594
00:31:36,200 --> 00:31:37,480
this. 
You've got to get good quality 

595
00:31:37,480 --> 00:31:39,960
sleep. 
And they're like, I try, I just,

596
00:31:39,960 --> 00:31:42,280
I can't, right? 
I lay there awake at night and I

597
00:31:42,280 --> 00:31:46,560
can't sleep and so talking to a 
provider or talking through what

598
00:31:46,560 --> 00:31:49,400
are your options because there 
are great options for getting 

599
00:31:49,400 --> 00:31:51,000
you to sleep for helping you get
to sleep. 

600
00:31:51,360 --> 00:31:54,120
Melatonin among them, but 
there's lots of sleepytime 

601
00:31:54,120 --> 00:31:58,000
herbs. 
Magnesium inositol is a type of 

602
00:31:58,880 --> 00:32:01,320
it is a type of sugar but 
doesn't raise our blood sugar 

603
00:32:01,680 --> 00:32:05,720
and it helps to prevent the 
accumulation of beta amyloid 

604
00:32:05,720 --> 00:32:09,040
plaques also helps us to get to 
sleep and get restful sleep. 

605
00:32:09,440 --> 00:32:12,120
Now, if you have trouble staying
asleep, so long as you're not on

606
00:32:12,120 --> 00:32:16,520
antidepressants that are SSRI's,
you can take 5 HTP. 

607
00:32:16,520 --> 00:32:19,480
Serotonin helps us to stay 
asleep where melatonin helps us 

608
00:32:19,480 --> 00:32:22,040
get to sleep. 
And then phosphatidylstirine, 

609
00:32:22,040 --> 00:32:24,760
there's a product in particular 
that I like called Serifos. 

610
00:32:24,760 --> 00:32:28,600
It's a high dose that can help 
you to reduce, basically 

611
00:32:28,600 --> 00:32:30,720
metabolize cortisol before 
you're going to bed. 

612
00:32:31,000 --> 00:32:33,320
So that as your cortisol comes 
up in the morning, if it's 

613
00:32:33,320 --> 00:32:37,440
coming up at 34 AM and you want 
to sleep until six or seven, you

614
00:32:37,440 --> 00:32:40,520
can take Serifos before you go 
to bed and that'll help to keep 

615
00:32:40,520 --> 00:32:43,640
the cortisol down throughout the
night so that you don't that 

616
00:32:43,640 --> 00:32:47,280
threshold that triggers the 
waking response until a little 

617
00:32:47,280 --> 00:32:50,080
bit later. 
It's also Pinocchio, Magnolia 

618
00:32:50,080 --> 00:32:51,520
bark. 
There's a product called Hono 

619
00:32:51,520 --> 00:32:55,040
Pure that I really like that 
helps people with more restful 

620
00:32:55,040 --> 00:32:57,360
sleep. 
There are so many things that we

621
00:32:57,360 --> 00:33:02,600
can do to optimize sleep now #1 
and it sounds like you probably 

622
00:33:02,600 --> 00:33:05,640
already are aware of this, but 
it's that sleep hygiene and 

623
00:33:05,640 --> 00:33:11,360
allowing enough time for restful
sleep and meditation is one of 

624
00:33:11,360 --> 00:33:14,760
my, I mean, I think meditation 
is probably the best medicine 

625
00:33:16,480 --> 00:33:21,480
that it makes a profound impact 
on the quality of sleep as well.

626
00:33:22,240 --> 00:33:24,840
Yeah, I don't, I don't have a 
problem falling asleep or 

627
00:33:24,840 --> 00:33:27,440
staying asleep unless I am in a 
a prep and then my body is like 

628
00:33:27,440 --> 00:33:30,880
just fight or flight mode and it
it wakes up super early without 

629
00:33:30,880 --> 00:33:33,520
me wanting it to. 
But I think the quality of my 

630
00:33:33,520 --> 00:33:36,640
sleep while I sleep is probably 
subpar. 

631
00:33:36,640 --> 00:33:39,800
And it's probably because I've 
just got this underlying chronic

632
00:33:39,800 --> 00:33:42,600
level of stress that just 
doesn't let me to truly deeply 

633
00:33:42,600 --> 00:33:44,880
relax. 
That's my theory at least. 

634
00:33:46,000 --> 00:33:49,600
But I guess I'm probably 
breathing poorly as well, some 

635
00:33:49,600 --> 00:33:52,480
form of mild sleep apnea, 
because if I'm snoring to any 

636
00:33:52,480 --> 00:33:54,000
extent then that would indicate 
that, right? 

637
00:33:54,880 --> 00:33:57,040
Well, it could, yeah, there's 
something happening in the 

638
00:33:57,040 --> 00:33:58,240
airway. 
It's not ideal. 

639
00:33:58,240 --> 00:34:02,200
And when when people have sleep 
apnea, you're not going to be 

640
00:34:02,200 --> 00:34:04,200
able to get restful sleep 
because your body thinks that 

641
00:34:04,200 --> 00:34:06,760
you're suffocating, right? 
So I think some people are like,

642
00:34:06,760 --> 00:34:09,400
oh, no, it's not a big deal. 
I get enough sleep and maybe I 

643
00:34:09,400 --> 00:34:11,920
have a little apnea. 
It's like, no, no, you're 

644
00:34:11,920 --> 00:34:13,800
hypoxic. 
Your brain is not getting enough

645
00:34:13,800 --> 00:34:15,679
oxygen. 
That's essentially like mild 

646
00:34:15,679 --> 00:34:18,280
brain damage every night. 
Yeah, I definitely, I definitely

647
00:34:18,280 --> 00:34:20,400
want to avoid that for sure. 
Yeah. 

648
00:34:20,960 --> 00:34:24,600
But I would imagine that is 
amplified on a whole nother 

649
00:34:24,600 --> 00:34:28,639
level with elderly people that 
for sure have sleep apnea and 

650
00:34:28,639 --> 00:34:31,440
it's just going undiagnosed or 
unrecognized and that's just 

651
00:34:31,440 --> 00:34:34,040
their norm every single night. 
Absolutely. 

652
00:34:34,040 --> 00:34:37,520
But you know, even in our 20s, 
thirties, 40s, just one night of

653
00:34:37,520 --> 00:34:41,040
sleep deprivation leads to a 
measurable accumulation of 

654
00:34:41,040 --> 00:34:43,040
amyloid plaque in the cerebral 
spinal fluid. 

655
00:34:43,560 --> 00:34:45,120
Yeah, definitely something to be
avoided. 

656
00:34:46,719 --> 00:34:51,520
So you mentioned the structure 
and systems and and you double 

657
00:34:51,520 --> 00:34:53,679
clicked on sleep as it pertains 
to structure. 

658
00:34:53,679 --> 00:34:57,560
What is the systems then? 
Oh, structure and stress 

659
00:34:58,400 --> 00:35:01,800
probably so and structure. 
So just like nutrients, we have 

660
00:35:01,800 --> 00:35:04,120
micro and macro with with 
structure we have micro and 

661
00:35:04,120 --> 00:35:06,640
macro as well. 
So the airway is what we were 

662
00:35:06,640 --> 00:35:09,120
just tracking chatting about, 
but also chronic pain. 

663
00:35:09,440 --> 00:35:14,040
So chronic pain will in increase
cortisol, a stress hormone, and 

664
00:35:14,040 --> 00:35:18,200
that over time can be toxic to 
the brain and that can shrink 

665
00:35:18,200 --> 00:35:20,280
the hippocampus, the memory 
center of our brain. 

666
00:35:20,600 --> 00:35:23,920
So too much stress can be an 
issue. 

667
00:35:24,920 --> 00:35:28,840
And if we're not getting enough 
sleep or if we're in chronic 

668
00:35:28,840 --> 00:35:32,120
pain, that can increase that 
toxic cortisol level. 

669
00:35:32,120 --> 00:35:34,920
Now we need some cortisol to get
us up and out of bed, but again,

670
00:35:34,920 --> 00:35:37,360
it's that too much. 
If we have too much at the wrong

671
00:35:37,360 --> 00:35:40,160
time then we can't sleep and it 
becomes toxic to the brain. 

672
00:35:40,760 --> 00:35:45,240
And also with structure is APOE.
The genetics or molecular 

673
00:35:45,240 --> 00:35:48,080
structure can also put us at 
higher risk for developing 

674
00:35:48,080 --> 00:35:52,360
dementia. 
So the APOEAPOE, you get one 

675
00:35:52,360 --> 00:35:55,640
from mom and one from dad. 
You can have a 2-3 or four from 

676
00:35:55,640 --> 00:36:00,640
mom or dad and if you have one 
copy of the four, you have a 30%

677
00:36:00,640 --> 00:36:03,120
chance of being diagnosed with 
dementia in your lifetime as 

678
00:36:03,120 --> 00:36:05,480
compared to people with in the 
full. 

679
00:36:05,720 --> 00:36:09,400
The full population is 13%. 
If you don't have APOE 4, it 

680
00:36:09,400 --> 00:36:12,440
goes down to 9%. 
Now, if you have two copies of 

681
00:36:12,440 --> 00:36:16,400
APOE 41 from Mom and one from 
Dad, you end up with a greater 

682
00:36:16,400 --> 00:36:20,040
than 50% likelihood that you 
will be diagnosed with dementia 

683
00:36:20,200 --> 00:36:22,040
in your Alzheimer's in your 
lifetime. 

684
00:36:22,440 --> 00:36:25,520
And there was a recent Nature 
paper that was published that 

685
00:36:25,600 --> 00:36:28,160
essentially suggested that it 
was inevitable that you would 

686
00:36:28,160 --> 00:36:31,880
get Alzheimer's if you lived up 
to a certain age and that most 

687
00:36:31,880 --> 00:36:36,200
people over 65 who are APOE 4/4 
positive have enough amyloid to 

688
00:36:36,200 --> 00:36:41,640
be diagnosed with Alzheimer's. 
So this is scary, but it's also,

689
00:36:41,640 --> 00:36:44,680
I hope, very empowering. 
If we know we have genetic risk 

690
00:36:44,680 --> 00:36:48,080
for dementia, we want to 
understand our risk factors 

691
00:36:48,160 --> 00:36:50,840
earlier on, in our 20s, 
thirties, 40s, before we have 

692
00:36:50,960 --> 00:36:54,720
any inkling of symptoms and take
control of our brain health. 

693
00:36:55,400 --> 00:36:59,720
So stress is the other one that 
we can chat about here and 

694
00:36:59,720 --> 00:37:03,000
stress again, it's you don't 
want too much and you don't want

695
00:37:03,000 --> 00:37:05,680
too little on the too little 
side. 

696
00:37:05,680 --> 00:37:09,160
Many people associate their 
retirement years right with 

697
00:37:09,160 --> 00:37:12,120
kicking their feet up, maybe 
enjoying cocktails at happy hour

698
00:37:12,600 --> 00:37:16,440
and watching TV, going on cruise
route, a cruise ship, you know, 

699
00:37:16,440 --> 00:37:20,040
adventures, eating to to the 
point of gluttony. 

700
00:37:20,720 --> 00:37:23,600
And that is going to set you up 
for dementia and Alzheimer's and

701
00:37:23,600 --> 00:37:26,560
heart disease and you know, a 
myriad of other complex chronic 

702
00:37:26,560 --> 00:37:29,640
diseases as you age. 
We need engagement. 

703
00:37:29,640 --> 00:37:32,920
You want stress, not too much of
it, but you want the type of 

704
00:37:32,920 --> 00:37:35,960
stress that provides purpose and
meaning, right? 

705
00:37:35,960 --> 00:37:38,840
My daughter started kindergarten
this morning and her grandpa 

706
00:37:39,080 --> 00:37:40,720
helped get her to and from 
school. 

707
00:37:41,080 --> 00:37:43,360
It's kind of stressful and 
overwhelming for him, but it's 

708
00:37:43,360 --> 00:37:46,680
so meaningful and it keeps him 
engaged, right? 

709
00:37:46,680 --> 00:37:48,440
And at the end of the day, he 
enjoys it. 

710
00:37:49,360 --> 00:37:53,600
But you, I think some people 
imagine retirement is having no 

711
00:37:53,600 --> 00:37:57,960
responsibility, but you want to 
be engaging in the things that 

712
00:37:57,960 --> 00:38:00,440
you love and creative pursuits 
in. 

713
00:38:00,680 --> 00:38:04,680
You want to be doing something. 
You want to be exercising. 

714
00:38:04,680 --> 00:38:07,640
Exercise is another very classic
one with stress. 

715
00:38:07,640 --> 00:38:10,240
The, I'm sure your, your 
audience is well aware of the 

716
00:38:10,240 --> 00:38:14,800
hormatic effect and this concept
that an increase in stress 

717
00:38:14,800 --> 00:38:16,560
actually creates more 
resilience. 

718
00:38:16,600 --> 00:38:20,520
That is exercise, right? 
We're getting micro tears in the

719
00:38:20,520 --> 00:38:24,440
muscle so that we have bigger 
muscle and then we're stronger 

720
00:38:24,440 --> 00:38:27,160
and we're more resilient when 
the next stressor comes up. 

721
00:38:27,480 --> 00:38:29,600
So we can do that with fasting, 
the making diets like the 

722
00:38:29,600 --> 00:38:32,080
ketogenic diet, with exercise. 
Of course, we can do this with 

723
00:38:32,080 --> 00:38:35,880
hot and cold therapy. 
We can do this even with oxygen 

724
00:38:35,880 --> 00:38:39,440
contrast, oxygen therapy to 
increase resilience in the 

725
00:38:39,440 --> 00:38:42,720
system, which is more or less a 
definition of health, right? 

726
00:38:42,840 --> 00:38:47,040
So with stress, we want to use 
that hormetic effect. 

727
00:38:47,040 --> 00:38:49,760
We want to stress the system 
enough that it becomes more 

728
00:38:49,760 --> 00:38:53,600
resilient and it stays engaged, 
but too much stress. 

729
00:38:53,600 --> 00:38:57,440
So, for example, people who 
provide care to those suffering 

730
00:38:57,440 --> 00:39:01,880
with dementia and Alzheimer's, 
that is a very stressful role, 

731
00:39:01,880 --> 00:39:05,920
often with a high, a high 
burden, and it can interfere 

732
00:39:05,920 --> 00:39:09,080
with sleep, with exercise, with 
diet routines. 

733
00:39:09,560 --> 00:39:12,920
And people who serve as 
caregivers are anywhere from 2 

734
00:39:12,920 --> 00:39:15,760
1/2 to six times more likely to 
be diagnosed with Alzheimer's 

735
00:39:15,760 --> 00:39:18,400
themselves later in life 
compared to those who do not 

736
00:39:18,400 --> 00:39:22,120
serve as a caregiver. 
And that is, I think, the 

737
00:39:22,120 --> 00:39:26,600
manifestation of the risk of 
this stress, of too much stress.

738
00:39:27,520 --> 00:39:29,920
Yeah, I feel like that. 
And especially in this day and 

739
00:39:29,920 --> 00:39:32,400
age, like people are just 
walking around with stress and 

740
00:39:32,400 --> 00:39:35,640
they don't even necessarily 
recognize that they're stressed,

741
00:39:35,680 --> 00:39:38,240
but they are doing things 
day-to-day, like just simply 

742
00:39:38,520 --> 00:39:41,320
scrolling on social media 
mindlessly and comparing 

743
00:39:41,320 --> 00:39:44,320
yourself to others. 
Like you may not feel stressed, 

744
00:39:44,840 --> 00:39:48,280
innately stressed from that, but
like your body recognizes it as 

745
00:39:48,280 --> 00:39:50,240
stress. 
And that's just like the chronic

746
00:39:50,240 --> 00:39:54,240
norm that everybody's doing. 
It's also that lack of purpose 

747
00:39:54,240 --> 00:39:57,120
and meaning, right when you're 
just mindlessly scrolling, you 

748
00:39:57,120 --> 00:40:01,000
don't have the benefit of 
putting the grit into like a 

749
00:40:01,000 --> 00:40:03,520
project and seeing it to 
completion because you're just 

750
00:40:03,520 --> 00:40:06,080
there for the dopamine hit of, 
of the scroll. 

751
00:40:06,640 --> 00:40:08,840
And so I think it's twofold, 
right? 

752
00:40:08,840 --> 00:40:10,600
We have the depression for a 
couple reasons. 

753
00:40:10,680 --> 00:40:13,480
I'm sure many of us I've, I 
certainly have the experience of

754
00:40:13,480 --> 00:40:15,920
being kind of burnt out after a 
long work week and. 

755
00:40:16,360 --> 00:40:20,240
Or maybe travel and I get on 
Instagram and I'm scrolling and 

756
00:40:20,280 --> 00:40:22,880
all of a sudden a couple of 
hours have gone by and I just 

757
00:40:22,880 --> 00:40:25,840
feel bad about myself. 
Not just because I'm comparing 

758
00:40:25,840 --> 00:40:28,760
myself to others and like 
dreaming of that amazing trip to

759
00:40:28,760 --> 00:40:31,800
Italy or or Tahiti or whatever. 
I just, you know, scrolled 

760
00:40:31,800 --> 00:40:34,400
through. 
But more because I was so 

761
00:40:34,440 --> 00:40:36,680
unproductive. 
I didn't do anything. 

762
00:40:36,920 --> 00:40:39,080
I didn't get exercise that made 
me feel good. 

763
00:40:39,080 --> 00:40:42,320
I didn't read a book that, you 
know, inspired me in some way. 

764
00:40:43,000 --> 00:40:47,720
I just scrolled for hours. 
Yeah, I think it's definitely a 

765
00:40:47,720 --> 00:40:49,280
downward spiral that a lot of 
people face. 

766
00:40:49,280 --> 00:40:52,160
I feel like on the point that 
you just said, they're like 

767
00:40:52,160 --> 00:40:54,880
having a goal, having a project 
that you're working on, like 

768
00:40:54,880 --> 00:41:00,480
that sense of fulfillment that 
comes from that is so incredibly

769
00:41:00,720 --> 00:41:03,680
rewarding and empowering. 
I feel like very few people 

770
00:41:04,000 --> 00:41:06,480
unfortunately have that like 
that they're working jobs they 

771
00:41:06,600 --> 00:41:09,520
they dislike, they're they're 
stuck in the monotony of a life 

772
00:41:09,520 --> 00:41:12,480
they're not passionate about. 
And I think there is so much to 

773
00:41:12,480 --> 00:41:17,360
be said from a health standpoint
when you are doing your desired 

774
00:41:17,360 --> 00:41:19,920
tasks every single day now. 
So there's not going to be hard 

775
00:41:20,040 --> 00:41:21,800
moments in there. 
There's not going to be a grind 

776
00:41:21,800 --> 00:41:23,480
to it. 
But when you are working on 

777
00:41:23,480 --> 00:41:26,600
something that you truly believe
in, I think there is like very 

778
00:41:26,600 --> 00:41:28,800
tangible health benefits that 
come from that. 

779
00:41:30,240 --> 00:41:34,360
Having purpose and meaning 
throughout life is so I think 

780
00:41:34,360 --> 00:41:36,360
important to our mental health, 
certainly. 

781
00:41:37,160 --> 00:41:41,160
And I think that there's always 
this, right, this too much, too 

782
00:41:41,160 --> 00:41:44,280
little. 
If you have work that takes over

783
00:41:44,280 --> 00:41:46,640
your life, right? 
As I mentioned, I feel so 

784
00:41:46,640 --> 00:41:49,440
privileged to talk to older 
people who and I can ask them at

785
00:41:49,440 --> 00:41:53,040
the end, looking back, what's 
most important to you, right? 

786
00:41:53,040 --> 00:41:55,680
Work has to fit into real life, 
right? 

787
00:41:55,680 --> 00:41:59,880
It has to fit in to our sleep, 
our health, like our our 

788
00:41:59,880 --> 00:42:03,400
priorities. 
And if your stated priorities 

789
00:42:03,400 --> 00:42:06,640
are your health and your family,
but you spend all of your time 

790
00:42:06,640 --> 00:42:08,840
working and you're not getting 
sleep at night or you're not 

791
00:42:08,840 --> 00:42:13,040
making time to exercise, then 
your priorities don't match. 

792
00:42:13,560 --> 00:42:16,200
Your state of priorities don't 
match how you're spending your 

793
00:42:16,200 --> 00:42:18,720
time. 
And that leads to incongruence. 

794
00:42:19,320 --> 00:42:22,480
And so there, which can be also 
very stressful, right? 

795
00:42:22,480 --> 00:42:27,080
So I think that there's, this is
dynamic again, this changes over

796
00:42:27,080 --> 00:42:31,040
time and it requires sort of 
reevaluating and looking at 

797
00:42:31,040 --> 00:42:33,880
repeatedly throughout life. 
And especially as things change,

798
00:42:33,880 --> 00:42:37,080
you know, children grow or when 
you hit retirement or you 

799
00:42:37,080 --> 00:42:40,200
graduate from a program or you 
make a big decision to shift 

800
00:42:40,200 --> 00:42:42,880
your life because maybe you're 
in a, in a job that doesn't feel

801
00:42:42,880 --> 00:42:46,760
purposeful and meaningful. 
But then having that opportunity

802
00:42:47,360 --> 00:42:50,240
those weekends away or, or that 
coaching program or that 

803
00:42:50,240 --> 00:42:53,480
therapist that you work with to 
just constantly, kind of maybe 

804
00:42:53,480 --> 00:42:55,640
not constantly, but you know, 
regularly go back and 

805
00:42:55,640 --> 00:42:58,720
reevaluate. 
Do my priorities, my stated 

806
00:42:58,720 --> 00:43:00,840
priorities, match the way I'm 
spending my time? 

807
00:43:01,480 --> 00:43:04,280
Well, I have to to applaud you 
because I can tell just in 

808
00:43:04,280 --> 00:43:08,280
talking with you like the the 
zeal for life that you have in 

809
00:43:08,280 --> 00:43:11,320
doing the work that you're doing
is very, very evident and just 

810
00:43:11,320 --> 00:43:13,720
the way you're communicating. 
So I have no doubt that you are 

811
00:43:14,080 --> 00:43:17,080
finding, seeking and living that
purpose every single day. 

812
00:43:18,040 --> 00:43:23,000
I feel so privileged really. 
I, I, I get to hear people say, 

813
00:43:23,000 --> 00:43:27,760
I got my mom back and, you know,
recount their incredible holiday

814
00:43:27,760 --> 00:43:31,800
season that they had with her 
and that I just feel so 

815
00:43:31,800 --> 00:43:34,120
delighted. 
But I also get to drop my 

816
00:43:34,120 --> 00:43:37,200
daughter off at, at school in 
the morning and pick her up in 

817
00:43:37,200 --> 00:43:38,960
the afternoon, right? 
It's, it's about and take her 

818
00:43:38,960 --> 00:43:42,720
camping and, and, you know, be 
in awe of nature with her. 

819
00:43:43,280 --> 00:43:46,520
And I think that that that 
balance is really important. 

820
00:43:46,800 --> 00:43:50,960
100% So I've got to, I want to, 
I want to talk tangibles here. 

821
00:43:51,040 --> 00:43:53,840
I've got, I mean, we all have 
people in our family that are 

822
00:43:54,520 --> 00:43:58,280
older and they're going through 
cognitive decline, health 

823
00:43:58,280 --> 00:44:00,680
decline. 
They're just facing the 

824
00:44:00,680 --> 00:44:01,880
challenges that come with 
getting older. 

825
00:44:02,280 --> 00:44:05,920
And one of my big frustrations, 
I'm sure a lot of people that 

826
00:44:05,920 --> 00:44:07,840
can relate to this, especially 
if they're listening to the 

827
00:44:07,840 --> 00:44:11,120
health oriented podcast, is that
they feel like they know the 

828
00:44:11,120 --> 00:44:14,760
solution, whether that is a 
ketogenic diet, more activity 

829
00:44:15,000 --> 00:44:18,320
reduced, you know, processed 
sugars, like any of those things

830
00:44:18,320 --> 00:44:22,680
would benefit our older loved 
ones that are in that state. 

831
00:44:23,040 --> 00:44:28,400
However, so many people have 
this notion of like, hey, 

832
00:44:29,080 --> 00:44:31,960
they're old, they're they're 
stuck in their habits. 

833
00:44:31,960 --> 00:44:35,000
Just let them do whatever they 
want to do and live out their 

834
00:44:35,000 --> 00:44:38,160
last years as they wish. 
Like to me, I've got a very hard

835
00:44:38,160 --> 00:44:41,760
time embracing that mindset. 
Like how do you combat that? 

836
00:44:43,400 --> 00:44:47,200
So this is. 
This comes up all the time. 

837
00:44:47,240 --> 00:44:50,880
And I see especially women 
daughters, right? 

838
00:44:50,880 --> 00:44:53,920
They're they're just almost 
become a martyr to this idea 

839
00:44:53,920 --> 00:44:55,880
that like my mom is not getting 
the best care. 

840
00:44:55,880 --> 00:44:57,960
She needs more. 
My sister's wrong. 

841
00:44:57,960 --> 00:45:01,520
I'm right. 
And I think that there's a 

842
00:45:01,520 --> 00:45:04,200
balance here, right? 
Like you can take it too far. 

843
00:45:04,200 --> 00:45:08,720
And our parents are our parents,
right? 

844
00:45:08,720 --> 00:45:13,200
And they do have agency and it's
important to respect their 

845
00:45:13,200 --> 00:45:14,640
wishes. 
And I think that this is very 

846
00:45:14,640 --> 00:45:18,280
complicated, especially because 
the wishes of someone at 60 

847
00:45:18,280 --> 00:45:22,160
compared to their 80 year old 
demented self might be very 

848
00:45:22,160 --> 00:45:24,240
different. 
And then it's whose wishes do we

849
00:45:24,240 --> 00:45:27,280
grant at this stage? 
The the 60 year old who wrote 

850
00:45:27,280 --> 00:45:31,200
their their will or, or their 
ideas of how their estate would 

851
00:45:31,200 --> 00:45:34,720
be handled? 
Or the 80 year old who's very, 

852
00:45:34,880 --> 00:45:37,360
you know, lucidly telling me 
that they want to marry this 

853
00:45:37,360 --> 00:45:39,840
person or that they want to, you
know, do this other thing. 

854
00:45:40,440 --> 00:45:42,680
And it's so out of character And
I, I don't think that there's 

855
00:45:42,800 --> 00:45:46,920
right answers to all of this. 
But I will say that if you feel 

856
00:45:47,160 --> 00:45:49,200
well when there's a lot more 
resource, right there's Dean 

857
00:45:49,200 --> 00:45:51,840
Ornish just published a trial. 
Now his was not on. 

858
00:45:52,240 --> 00:45:56,640
So he Dean, Dean Ornish is up at
UCSF and he's created programs 

859
00:45:56,640 --> 00:45:59,040
for heart disease and for other 
chronic diseases associated with

860
00:45:59,040 --> 00:46:01,680
aging. 
But he had a very recent 

861
00:46:02,080 --> 00:46:05,360
randomized control trial, the 
1st randomized control child, 

862
00:46:05,360 --> 00:46:08,160
showing that an intervention, a 
lifestyle intervention like 

863
00:46:08,160 --> 00:46:10,800
this, a multimodal lifestyle 
intervention for those suffering

864
00:46:10,800 --> 00:46:14,600
with mild cognitive impairment 
and early Alzheimer's, was 

865
00:46:14,600 --> 00:46:16,840
effective in improving 
cognition. 

866
00:46:17,240 --> 00:46:21,160
And so this was followed my 
paper that was published showing

867
00:46:21,160 --> 00:46:23,760
that we could reverse cognitive 
decline associated with 

868
00:46:23,760 --> 00:46:25,520
Alzheimer's. 
And also Doctor Braddeson's 

869
00:46:25,520 --> 00:46:30,600
work, he used a vegan diet, but 
this can be done and the 

870
00:46:30,600 --> 00:46:33,120
research is there. 
So don't let anyone tell you 

871
00:46:33,120 --> 00:46:34,960
that there's no research 
supporting lifestyle 

872
00:46:34,960 --> 00:46:37,720
interventions for cognitive 
decline and what leads to 

873
00:46:37,720 --> 00:46:39,800
Alzheimer's. 
So the research is there. 

874
00:46:39,800 --> 00:46:41,960
You can point to the research. 
You can point to my book 

875
00:46:41,960 --> 00:46:44,280
Reversing Alzheimer's. 
You can point to Doctor 

876
00:46:44,280 --> 00:46:47,600
Bredesen's books, The End of 
Alzheimer's, The First Survivors

877
00:46:47,600 --> 00:46:50,120
of Alzheimer's, and the The End 
of Alzheimer's Program. 

878
00:46:50,360 --> 00:46:54,440
Those are great books as well 
that all describe how to do 

879
00:46:54,440 --> 00:46:57,920
this. 
And I share many stories, true 

880
00:46:57,920 --> 00:47:00,240
patient stories of people who 
have reversed their cognitive 

881
00:47:00,240 --> 00:47:02,240
decline. 
So those stories are there. 

882
00:47:02,240 --> 00:47:07,440
The research is there, and if 
you give that to your loved 

883
00:47:07,440 --> 00:47:09,960
ones, and I think how you 
communicate with them is 

884
00:47:09,960 --> 00:47:11,840
important too, right? 
We don't want to be too pushy 

885
00:47:11,840 --> 00:47:13,400
because that just makes people 
resist. 

886
00:47:13,760 --> 00:47:16,400
But we can have all the answers.
But if we don't communicate them

887
00:47:16,400 --> 00:47:18,760
effectively, they're not going 
to be receptive to it. 

888
00:47:18,760 --> 00:47:21,440
And sometimes there's family 
dynamics that make people not 

889
00:47:21,440 --> 00:47:23,600
receptive. 
But if you feel like you're 

890
00:47:23,600 --> 00:47:26,680
banging your head against a 
wall, that's a traumatic brain 

891
00:47:26,680 --> 00:47:28,320
injury that falls under 
structure. 

892
00:47:28,560 --> 00:47:32,680
Stop bringing your head against 
the wall wall and refocus your 

893
00:47:32,680 --> 00:47:35,360
energy on making sure that you, 
particularly if you're 

894
00:47:35,360 --> 00:47:38,720
genetically related to someone 
with dementia, that you are 

895
00:47:38,720 --> 00:47:41,480
taking responsibility for your 
own brain health. 

896
00:47:41,880 --> 00:47:45,840
And walking the the talk, right?
Like eating the diet, getting 

897
00:47:45,840 --> 00:47:49,360
the exercise, getting the sleep,
managing your stressors, maybe 

898
00:47:49,360 --> 00:47:52,400
getting tested for toxins or 
infections or sleep apnea. 

899
00:47:53,200 --> 00:47:57,600
And I think that that is the 
best use of that energy instead 

900
00:47:57,600 --> 00:48:00,560
of projecting it on others. 
And what they should be doing is

901
00:48:00,560 --> 00:48:03,240
making sure that you are doing 
everything that you can to 

902
00:48:03,240 --> 00:48:06,360
protect your brain health and 
being a model for those around 

903
00:48:06,360 --> 00:48:08,080
you. 
Yeah, and I completely agree on 

904
00:48:08,080 --> 00:48:10,120
all fronts there. 
And that's that rings true for 

905
00:48:10,120 --> 00:48:15,200
both the, you know, those in the
older, you know, age gaps groups

906
00:48:15,200 --> 00:48:17,520
and those that are on the 
complete other spectrum. 

907
00:48:17,520 --> 00:48:19,600
I've got people that have, you 
know, kids, they're trying to 

908
00:48:20,040 --> 00:48:23,160
showcase to them how they need 
to eat, yet they're not modeling

909
00:48:23,160 --> 00:48:24,960
that that correct behavior 
either. 

910
00:48:24,960 --> 00:48:27,400
So it's like you most definitely
have to practice what you preach

911
00:48:27,400 --> 00:48:31,000
and just be the best example you
can be for those older and for 

912
00:48:31,000 --> 00:48:33,400
those younger than you. 
So I completely resonate with 

913
00:48:33,400 --> 00:48:35,600
that message. 
It is frustrating when people 

914
00:48:35,840 --> 00:48:40,120
assume that people are past a 
point in life where change 

915
00:48:40,120 --> 00:48:43,160
cannot be made. 
And my, my opinion has always 

916
00:48:43,160 --> 00:48:46,200
been like, look, if if you get 
and one more day on this planet,

917
00:48:46,200 --> 00:48:49,280
you might as well do what you 
can to capitalize and make that 

918
00:48:49,280 --> 00:48:53,440
day the best it can be. 
And if you focus on controlling 

919
00:48:53,440 --> 00:48:55,120
the things that you do have 
control of, which is the food 

920
00:48:55,120 --> 00:48:57,480
you put in your mouth and your 
lifestyle factors, if that can 

921
00:48:57,800 --> 00:49:03,440
benefit the the you know, the 
happiness in that time left like

922
00:49:03,440 --> 00:49:06,200
that is all time energy well 
spent. 

923
00:49:07,080 --> 00:49:09,840
Maureen came into my office and 
I share the story in the book, 

924
00:49:09,840 --> 00:49:12,600
but I'll share it here as well 
because I think it's to your 

925
00:49:12,600 --> 00:49:15,360
point. 
She came into my office and she 

926
00:49:15,360 --> 00:49:18,160
joined our clinical trial and it
was as a last ditch effort. 

927
00:49:18,160 --> 00:49:22,120
She was desperate, absolutely 
desperate because her husband 

928
00:49:22,120 --> 00:49:23,840
had passed away. 
He had also been her business 

929
00:49:23,840 --> 00:49:25,760
partner. 
They'd owned a nursery and the 

930
00:49:25,760 --> 00:49:27,520
nursery had just gone into 
disrepair. 

931
00:49:27,520 --> 00:49:30,640
She hadn't done our taxes in 
years and she only they didn't 

932
00:49:30,640 --> 00:49:32,680
have kids. 
And so her only two living 

933
00:49:32,680 --> 00:49:35,080
relatives, her older siblings 
had passed away. 

934
00:49:35,680 --> 00:49:38,960
Her two living relatives were 
cousins who lived a couple of 

935
00:49:38,960 --> 00:49:42,600
hours away up in LA and they 
lived in this senior living 

936
00:49:42,600 --> 00:49:44,840
community where the model was 
age in place. 

937
00:49:44,840 --> 00:49:48,440
So you could buy in and you 
could move in at a certain rate 

938
00:49:48,440 --> 00:49:52,320
and the rate didn't change. 
But if you had any indication 

939
00:49:52,320 --> 00:49:55,120
that you had dementia or 
cognitive decline, you weren't 

940
00:49:55,120 --> 00:49:57,640
eligible because it's so 
expensive to care for people and

941
00:49:57,640 --> 00:49:59,680
memory care. 
So they wanted to reduce their 

942
00:49:59,680 --> 00:50:02,280
numbers of that, right? 
So I got where they were coming 

943
00:50:02,280 --> 00:50:04,360
from. 
But she was also in this very 

944
00:50:04,360 --> 00:50:08,040
desperate place of feeling like 
she was going to die alone in 

945
00:50:08,040 --> 00:50:12,800
her home, demented. 
And it was terrifying for her. 

946
00:50:12,920 --> 00:50:17,080
Now she would call my office. 
Like my staff literally had to 

947
00:50:17,080 --> 00:50:19,960
say on Monday mornings, I have 
to put aside an hour and a half 

948
00:50:19,960 --> 00:50:22,520
to listen to all of the messages
that Maureen leftover the 

949
00:50:22,520 --> 00:50:24,600
weekend. 
And she was calling multiple 

950
00:50:24,600 --> 00:50:26,040
times a day. 
Like if somebody, if you think 

951
00:50:26,040 --> 00:50:28,760
of somebody needing handheld, 
she needed, like, both hands 

952
00:50:28,760 --> 00:50:30,120
held all the time. 
Yeah. 

953
00:50:30,400 --> 00:50:33,560
And my health coach, who we were
working with at the time, she 

954
00:50:33,560 --> 00:50:35,400
called me up. 
And she's like, Heather, Are you

955
00:50:35,400 --> 00:50:37,600
sure you want to let her into 
the trial? 

956
00:50:37,600 --> 00:50:40,640
Because I think like on a 
readiness score level, she's 

957
00:50:40,640 --> 00:50:42,240
like a generous, it's 2 out of 
10. 

958
00:50:43,200 --> 00:50:46,880
Well, Fast forward to six months
later, Maureen, like, walks into

959
00:50:46,880 --> 00:50:49,000
the office. 
She's got perfect cognition. 

960
00:50:49,560 --> 00:50:52,080
She, you know, which is 
measurably improved by like 6 or

961
00:50:52,080 --> 00:50:54,360
eight points. 
She's twirling around in this 

962
00:50:54,360 --> 00:50:57,200
dress she hadn't worn in years. 
She's not even thinking about 

963
00:50:57,200 --> 00:50:59,560
senior living communities. 
She's got our taxes done. 

964
00:50:59,560 --> 00:51:02,840
She's out on dating apps. 
She's going to like dance, dance

965
00:51:02,840 --> 00:51:05,200
classes. 
She doesn't have time to see me 

966
00:51:05,200 --> 00:51:07,200
because she's going to go to 
lunch with her friend. 

967
00:51:07,760 --> 00:51:13,080
And it was just this absolutely 
miraculous transformation from 

968
00:51:13,080 --> 00:51:15,960
someone who we thought had no 
chance of doing it. 

969
00:51:16,520 --> 00:51:20,720
And it's like if Maureen can do 
it alone with poor cognition, I 

970
00:51:21,680 --> 00:51:25,080
mean, anyone can do this. 
It's a matter of will really. 

971
00:51:25,080 --> 00:51:27,320
And you know, something really 
interesting that happened to her

972
00:51:28,000 --> 00:51:30,840
on her journey about 3 months 
into the six month program with 

973
00:51:30,840 --> 00:51:34,200
us. 
She had a neighbour who was 

974
00:51:34,200 --> 00:51:37,600
diagnosed with cancer. 
And so she had changed her diet 

975
00:51:37,600 --> 00:51:39,200
and was cooking all these 
healthy foods. 

976
00:51:39,200 --> 00:51:42,280
Lots of Brasca family, you know,
she was eating a lot of cabbage 

977
00:51:42,280 --> 00:51:46,240
and broccoli and cauliflower and
kale and Chard and all of the 

978
00:51:46,280 --> 00:51:48,800
veggies and had gotten really 
into cooking. 

979
00:51:49,000 --> 00:51:51,000
But she was only cooking for 
herself at that stage. 

980
00:51:51,000 --> 00:51:53,960
And when he was diagnosed with 
cancer, she started cooking for 

981
00:51:53,960 --> 00:51:55,680
him too. 
And she made it about something 

982
00:51:55,680 --> 00:51:59,400
bigger than herself. 
And I think that that allowed 

983
00:51:59,400 --> 00:52:01,080
her to have a lot of staying 
power. 

984
00:52:01,200 --> 00:52:03,080
Yeah. 
It made her get up and make the 

985
00:52:03,080 --> 00:52:05,800
meals, even on the days that she
didn't really feel like it. 

986
00:52:06,280 --> 00:52:08,360
No, that's awesome. 
That's that's that's super cool,

987
00:52:08,360 --> 00:52:11,560
very inspiring. 
I I got one more follow up 

988
00:52:11,560 --> 00:52:13,360
question for you, but I want to 
hear about your book too. 

989
00:52:13,360 --> 00:52:15,440
So you get your book that that 
was published when? 

990
00:52:16,320 --> 00:52:19,760
June 11th was our launch date. 
And how's it been going so far? 

991
00:52:20,320 --> 00:52:21,880
Great. 
We have the New York Times list,

992
00:52:21,880 --> 00:52:23,720
which was, you know, every 
author's goal. 

993
00:52:23,720 --> 00:52:27,120
So we feel good about that and 
would love for more people. 

994
00:52:27,720 --> 00:52:32,040
The momentum of coming on this 
show and others is the hope is 

995
00:52:32,040 --> 00:52:34,600
that it has an impact, right? 
Is that someone picks it up, 

996
00:52:34,880 --> 00:52:37,800
passes it along, it gets in 
someone's hands who makes those 

997
00:52:37,800 --> 00:52:40,760
lifestyle decisions. 
That changes the trajectory of 

998
00:52:40,760 --> 00:52:43,400
their health and improves the 
quality of their relationships 

999
00:52:43,960 --> 00:52:46,800
and their health over the over 
that last chapter of life 

1000
00:52:46,840 --> 00:52:49,160
especially. 
I love it and, and what what is 

1001
00:52:49,160 --> 00:52:51,240
the where's the place to go to 
get that? 

1002
00:52:52,240 --> 00:52:55,520
Anywhere books are sold, the 
title is Reversing Alzheimer's, 

1003
00:52:55,520 --> 00:52:58,200
the New toolkit to improve 
Cognition and Protect Brain 

1004
00:52:58,200 --> 00:53:00,000
Health. 
And my name is Doctor Heather 

1005
00:53:00,000 --> 00:53:01,440
Sanderson. 
Awesome. 

1006
00:53:01,440 --> 00:53:04,760
I'll definitely get to that. 
So my question my my final 

1007
00:53:04,760 --> 00:53:07,600
question for you is a lot of 
people I love talking to older 

1008
00:53:07,600 --> 00:53:08,840
people. 
I love talking to older people 

1009
00:53:08,840 --> 00:53:12,360
that have lived a lot more life 
than I because they have, you 

1010
00:53:12,360 --> 00:53:14,880
know, a deeper perspective on 
things that matter, things that 

1011
00:53:14,880 --> 00:53:17,600
don't. 
And I try to be incredibly 

1012
00:53:17,600 --> 00:53:21,200
present whenever I'm with them. 
And they often times offer such 

1013
00:53:21,200 --> 00:53:24,560
insightful information. 
And a lot of times it's filled 

1014
00:53:24,560 --> 00:53:28,360
with, you know, some sense of 
regret and you you want to try 

1015
00:53:28,360 --> 00:53:32,000
and harness that and not be in a
similar position when you're at 

1016
00:53:32,000 --> 00:53:33,920
that stage in life. 
But you've got the interesting 

1017
00:53:33,920 --> 00:53:38,560
phenomena of talking to several 
elder people that are on the 

1018
00:53:38,560 --> 00:53:42,000
brink of feeling like they're on
their deathbed, but then have 

1019
00:53:42,000 --> 00:53:47,040
been rejuvenated. 
What kind of words of wisdom are

1020
00:53:47,040 --> 00:53:51,280
they offering you after having 
been to that point where they 

1021
00:53:51,280 --> 00:53:55,440
think it is the end, but then 
getting their, you know, life, 

1022
00:53:55,600 --> 00:53:57,640
even if it's not for a 
significant period of time, but 

1023
00:53:57,680 --> 00:54:00,920
but they're having another 
chapter to look forward to. 

1024
00:54:00,920 --> 00:54:02,040
What? 
What kind of insight are they 

1025
00:54:02,040 --> 00:54:04,880
giving you? 
Yeah, it's so interesting. 

1026
00:54:05,000 --> 00:54:07,160
But so a lot of people with 
Alzheimer's are actually not 

1027
00:54:07,160 --> 00:54:09,120
close to death, right. 
This is part of what's so 

1028
00:54:09,120 --> 00:54:11,760
torturous about it is that they 
live. 

1029
00:54:12,360 --> 00:54:15,640
It's often unpredictable. 
Some people will be very healthy

1030
00:54:15,640 --> 00:54:19,400
physically and falling apart 
mentally and cognitively. 

1031
00:54:19,840 --> 00:54:24,800
And so the, the people who I 
there was this interesting woman

1032
00:54:25,640 --> 00:54:28,280
when we took over Murama, the 
residential care facility for 

1033
00:54:28,280 --> 00:54:30,680
the elderly, where we offer an 
immersive experience in this 

1034
00:54:30,680 --> 00:54:35,640
program, there were six people 
there who were on Hospice and 

1035
00:54:35,640 --> 00:54:36,800
they weren't part of our 
program. 

1036
00:54:36,800 --> 00:54:39,040
They just kind of, they came 
with the, the community with the

1037
00:54:39,480 --> 00:54:43,040
facility. 
And I would take, my daughter 

1038
00:54:43,040 --> 00:54:44,920
was a year old when, when that 
happened. 

1039
00:54:44,920 --> 00:54:48,080
And I would take my daughter in 
on my hip and see the different 

1040
00:54:48,080 --> 00:54:51,080
people on Hospice and check in 
on them. 

1041
00:54:51,160 --> 00:54:57,800
And this one woman, Valerie, she
said to me one day, you know, 

1042
00:54:58,480 --> 00:55:03,440
raising children, having little 
ones, that was the happiest time

1043
00:55:03,440 --> 00:55:07,400
of my life. 
Don't let it pass you by. 

1044
00:55:07,400 --> 00:55:11,280
It goes by so fast. 
And she was like, don't work too

1045
00:55:11,280 --> 00:55:14,120
hard, Doc. 
Like, be present for her, for 

1046
00:55:14,120 --> 00:55:17,920
my, for your little girl because
it will go so quickly. 

1047
00:55:18,360 --> 00:55:20,600
And again, you know, we hear 
this over and over. 

1048
00:55:21,600 --> 00:55:25,520
It's the connections, it's the 
family, it's it's the friends, 

1049
00:55:25,560 --> 00:55:29,520
the people that maybe we work 
with, but it's about the quality

1050
00:55:29,520 --> 00:55:33,000
of your relationships at the end
most of the time. 

1051
00:55:33,840 --> 00:55:36,720
No, I totally, totally agree. 
And it's, it's interesting 

1052
00:55:36,720 --> 00:55:40,800
because I feel like we all 
really know that, like we all 

1053
00:55:40,840 --> 00:55:46,400
inherently know that to be true,
yet so few of us live like that 

1054
00:55:46,400 --> 00:55:49,280
is our truth. 
Like we we agree with that, we 

1055
00:55:49,280 --> 00:55:50,600
say, yeah, that makes total 
sense. 

1056
00:55:51,240 --> 00:55:55,600
And then we just get stuck 
working non-stop or, you know, 

1057
00:55:55,600 --> 00:55:58,320
rushing off the next thing or 
not being present when you're 

1058
00:55:58,400 --> 00:56:00,320
with your parents, with your 
grandparents, with the great 

1059
00:56:00,320 --> 00:56:04,240
grandparents. 
Like it's like actually taking 

1060
00:56:04,960 --> 00:56:07,800
the the the actions that 
represent that knowledge and 

1061
00:56:07,800 --> 00:56:09,280
being. 
Yeah, and it's hard because 

1062
00:56:09,280 --> 00:56:10,760
sometimes you're assholes, 
right? 

1063
00:56:11,800 --> 00:56:15,200
It's just challenging and it's a
practice. 

1064
00:56:15,320 --> 00:56:18,640
And and this is again, what part
of why I think meditation is one

1065
00:56:18,640 --> 00:56:23,200
of the best medicines is because
it it, it helps us to practice 

1066
00:56:23,200 --> 00:56:27,760
that equanimity, that not being 
too frazzled when somebody says 

1067
00:56:27,760 --> 00:56:30,240
something that's offensive or 
when somebody doesn't show up in

1068
00:56:30,240 --> 00:56:33,400
the way we expect them to. 
And it allows us to deepen those

1069
00:56:33,400 --> 00:56:36,560
relationships without being too 
attached to outcomes or other 

1070
00:56:36,560 --> 00:56:40,680
people's behavior. 
And and so it it, but it's, 

1071
00:56:40,760 --> 00:56:43,360
yeah, it's important. 
And it's a practice. 

1072
00:56:43,360 --> 00:56:45,640
And, you know, take it for what 
it's worth. 

1073
00:56:46,000 --> 00:56:49,560
Yeah, no, I totally agree. 
I think, you know, removing the 

1074
00:56:50,160 --> 00:56:53,000
emotion from things like that 
that you can't control is key. 

1075
00:56:53,000 --> 00:56:57,120
Like knowing that you can look 
back on your life and recognize 

1076
00:56:57,120 --> 00:57:00,120
that, hey, you were there for 
the people in your in your life,

1077
00:57:00,120 --> 00:57:01,880
that you were there for your 
family members that you were 

1078
00:57:01,880 --> 00:57:04,720
there you were, you were always 
an open ear that they could talk

1079
00:57:04,720 --> 00:57:08,760
to or lean into. 
Like I think that would be the 

1080
00:57:08,760 --> 00:57:11,600
most valuable thing to be able 
to confidently say you were 

1081
00:57:11,600 --> 00:57:14,520
there for those that loved you 
and our families to you like 

1082
00:57:14,520 --> 00:57:15,880
that, that that's so very 
important. 

1083
00:57:16,640 --> 00:57:18,480
Yeah, how do you want to be 
remembered? 

1084
00:57:18,800 --> 00:57:21,920
Yeah, very cool. 
This, this is, it's got me. 

1085
00:57:22,280 --> 00:57:24,640
It's going to be thinking some 
deep thoughts here, I think. 

1086
00:57:24,720 --> 00:57:27,680
And this is so, so applicable to
everybody, like we all have 

1087
00:57:28,080 --> 00:57:31,360
family, we all have elder people
in our life, like we all have 

1088
00:57:31,440 --> 00:57:33,800
the need to preserve our own 
health so that when we are 

1089
00:57:33,800 --> 00:57:37,320
older, we we are not going 
through this cognitive decline 

1090
00:57:37,320 --> 00:57:39,640
ourselves. 
So I think the, the message that

1091
00:57:39,640 --> 00:57:42,640
you're preaching in the work 
that you're doing is incredibly 

1092
00:57:42,640 --> 00:57:44,480
impactful. 
And like I said, I could tell 

1093
00:57:44,480 --> 00:57:47,240
just in the way you're speaking 
that you're passionate about it.

1094
00:57:47,240 --> 00:57:49,920
So you are most definitely 
finding the good fight. 

1095
00:57:49,920 --> 00:57:53,440
And I think you are making 
you're making a difference on 

1096
00:57:53,440 --> 00:57:54,880
way on more ways than you 
recognize. 

1097
00:57:54,880 --> 00:57:57,680
So keep doing it. 
Well, Robert, thank you so much 

1098
00:57:57,680 --> 00:58:00,240
for having me. 
As you know, we both are huge 

1099
00:58:00,240 --> 00:58:04,160
fans of keto and like I said at 
the beginning, keto does I think

1100
00:58:04,160 --> 00:58:07,640
half of the heavy lifting. 
And so your work exposing people

1101
00:58:07,640 --> 00:58:13,240
to that, helping to teach them 
and get them access to such a 

1102
00:58:13,240 --> 00:58:16,880
life changing health promoting 
diet, I think is is just amazing

1103
00:58:16,880 --> 00:58:18,480
work in the world. 
So right back at you. 

1104
00:58:18,560 --> 00:58:20,840
I appreciate what all that you 
bring to the world. 

1105
00:58:20,960 --> 00:58:22,400
I appreciate that. 
I appreciate that. 

1106
00:58:22,400 --> 00:58:23,880
So I will definitely link out to
your book. 

1107
00:58:25,320 --> 00:58:28,440
And then as far as website, 
socials, any other place to find

1108
00:58:28,440 --> 00:58:30,720
you? 
Yeah, Doctor Heather 

1109
00:58:30,720 --> 00:58:33,960
sanderson.com where you can keep
up with the latest research and 

1110
00:58:33,960 --> 00:58:36,640
what we're doing to support 
those with Alzheimer's, dementia

1111
00:58:36,640 --> 00:58:38,160
and their families. 
Awesome. 

1112
00:58:38,280 --> 00:58:40,480
Only get to that as well. 
And if there's everything I can 

1113
00:58:40,480 --> 00:58:42,920
do to help move your message 
forward, by all means just let 

1114
00:58:42,920 --> 00:58:46,880
me know because I think, I mean,
you are making an impact and I 

1115
00:58:46,880 --> 00:58:48,720
feel like this is the message 
that needs to be heard. 

1116
00:58:48,720 --> 00:58:50,320
So by all means, keep preaching 
them. 

1117
00:58:51,560 --> 00:58:53,800
Thank you so much. 
It's such a privilege being here

1118
00:58:53,800 --> 00:58:55,080
with you, Robert. 
You bet. 

1119
00:58:55,160 --> 00:58:57,240
Well, take care. 
You as well.