1 00:00:00,040 --> 00:00:01,840 What's going on ladies and gents, Robert Sykes, Keto, 2 00:00:01,840 --> 00:00:03,720 savage.com. And today I've got special guest 3 00:00:03,720 --> 00:00:06,600 doctor Adeel Khan on the line and we dive deep into the 4 00:00:06,600 --> 00:00:11,200 wonderful world of stem cells. So this is medicine. 4 point O, 5 00:00:11,200 --> 00:00:14,480 as he calls it. We talk a lot about, we talk a 6 00:00:14,480 --> 00:00:16,840 lot about peptides. We talk a little bit about 7 00:00:16,840 --> 00:00:18,680 hormones. Talk a lot about stem cell 8 00:00:18,680 --> 00:00:21,680 therapy, gene editing therapy, where that is currently. 9 00:00:21,920 --> 00:00:25,640 What some of the bureaucratic red tape and pushback around 10 00:00:25,640 --> 00:00:28,560 that has been within conventional medicine, western 11 00:00:28,560 --> 00:00:30,440 medicine and where it's going to go in the future. 12 00:00:30,440 --> 00:00:33,000 What some of the use case scenarios for it would be, how 13 00:00:33,000 --> 00:00:36,960 it can promote longevity, preserving muscle tissue, 14 00:00:37,400 --> 00:00:40,920 reducing inflammation and just a host of use case scenarios in an 15 00:00:40,920 --> 00:00:44,920 often times unexpected realms like neurological function, 16 00:00:44,920 --> 00:00:46,880 things of that nature So thoroughly enjoy the 17 00:00:46,880 --> 00:00:48,880 conversation. I've learned a ton. 18 00:00:48,880 --> 00:00:52,160 Stem cell therapy is not what I would consider my wheelhouse at 19 00:00:52,160 --> 00:00:55,080 all, so I was very intrigued to learn more than I did with this 20 00:00:55,080 --> 00:00:57,840 conversation, so have no doubt you'll take something from it 21 00:00:57,840 --> 00:01:00,040 without further delay. Sit back, relax, enjoy the 22 00:01:00,040 --> 00:01:13,560 podcast with Doctor Khan and we are live Doctor Adil 23 00:01:13,560 --> 00:01:14,600 Khan. How are you Sir? 24 00:01:15,400 --> 00:01:16,600 Hey, good. How are you doing? 25 00:01:16,760 --> 00:01:20,360 I'm doing wonderfully well, man, so I know just enough about stem 26 00:01:20,360 --> 00:01:21,680 cell therapy to get me in trouble. 27 00:01:21,680 --> 00:01:23,760 Can you kind of peel the curtain back on that a little bit more? 28 00:01:24,880 --> 00:01:27,800 Yeah that I think that's most people's situation where they 29 00:01:27,800 --> 00:01:32,320 see and hear a few things here and there and it can it can lead 30 00:01:32,320 --> 00:01:36,040 them down a wary Rd. because there are a lot of stem cell 31 00:01:36,040 --> 00:01:39,560 offerings out there and the because of the lack of you know 32 00:01:39,560 --> 00:01:43,200 kind of approved therapies there's a lot of people kind of 33 00:01:43,200 --> 00:01:47,080 dipping their hands into non improved therapies and and and 34 00:01:47,080 --> 00:01:48,600 that's where you get where you can get into trouble. 35 00:01:48,600 --> 00:01:51,280 So. So stem cells you know 36 00:01:51,280 --> 00:01:54,960 themselves are not new the concept has been around for you 37 00:01:54,960 --> 00:01:57,560 know decades. But really what what the main 38 00:01:57,560 --> 00:02:00,600 message I want to get across is the stem cell engineering and 39 00:02:00,600 --> 00:02:04,160 manufacturing has improved significantly and if in to the 40 00:02:04,160 --> 00:02:07,760 point where we can actually gene edit them and engineer them to 41 00:02:07,760 --> 00:02:10,160 do what we want and it's just getting more and more 42 00:02:10,160 --> 00:02:12,560 sophisticated. But just to give everyone a bit 43 00:02:12,560 --> 00:02:16,160 of a background, stem cells are essentially these amazing 44 00:02:16,160 --> 00:02:18,480 molecules that you have all throughout your body that help 45 00:02:18,480 --> 00:02:21,960 to repair and regenerate tissue. And what makes them unique is 46 00:02:21,960 --> 00:02:24,840 their ability to turn into different types of tissue, but 47 00:02:24,840 --> 00:02:30,240 also to replicate and divide and and grow new tissue as well. 48 00:02:31,120 --> 00:02:34,440 Why is there so much red tape around stems as it pertains to 49 00:02:34,440 --> 00:02:38,400 conventional western medicine? Yeah, I mean that's a that's a 50 00:02:38,400 --> 00:02:41,680 long history lesson. But I'll I'll summarize what I 51 00:02:41,680 --> 00:02:46,080 think and this is based off my experience traveling working all 52 00:02:46,080 --> 00:02:48,120 over. You know I've worked in Japan, 53 00:02:48,120 --> 00:02:51,800 I've worked in Dubai, Middle East and in parts of Europe and 54 00:02:51,800 --> 00:02:54,440 South America and and obviously North America. 55 00:02:54,440 --> 00:03:01,440 So what I see the biggest reason is has unfortunately to do with 56 00:03:01,440 --> 00:03:07,240 the regulatory bodies who are overly friendly with the 57 00:03:07,240 --> 00:03:10,720 Pharmaceutical industry. And what that means is they just 58 00:03:10,720 --> 00:03:14,960 have lobbyists who help to prove certain things, and so they have 59 00:03:14,960 --> 00:03:17,840 methods and ways to get pharmaceutical approvals. 60 00:03:17,840 --> 00:03:21,880 But there's no real advocate for stem cells per SE because you 61 00:03:21,880 --> 00:03:26,520 can't really patent a stem cell at least the first generation of 62 00:03:26,520 --> 00:03:29,240 like umbilical cord stem cells. Now there are patented stem 63 00:03:29,240 --> 00:03:32,760 cells coming because you can create gene edited ones and have 64 00:03:32,760 --> 00:03:36,080 specific stem cells for specific issues and that's why big pharma 65 00:03:36,080 --> 00:03:39,040 is starting to dip their feet into this is is for that reason. 66 00:03:39,040 --> 00:03:42,640 But still the obviously making cell therapies is a lot more 67 00:03:42,640 --> 00:03:47,080 costly than making pills. So I think unfortunately it it's 68 00:03:47,080 --> 00:03:50,760 a real problem it's called the revolving door where a lot of 69 00:03:50,760 --> 00:03:54,560 the ex executives from pharma companies go and work for CDC 70 00:03:54,560 --> 00:03:58,080 who work for FDA and you know and they know one another and 71 00:03:58,080 --> 00:04:02,120 and that creates a lot of red tape because cell therapy has 72 00:04:02,360 --> 00:04:05,280 the potential and gene the cell and gene therapy because I like 73 00:04:05,280 --> 00:04:07,680 to bundle them together under the umbrella regenerative 74 00:04:07,680 --> 00:04:10,120 medicine have the have the potential to really disrupt 75 00:04:10,520 --> 00:04:12,560 traditional medicine. And it's obviously going to 76 00:04:12,560 --> 00:04:14,680 happen in our lifetime. It's where we started it. 77 00:04:15,200 --> 00:04:17,120 But there's obviously going to be push back anytime there's a 78 00:04:17,120 --> 00:04:19,160 new technology there's always going to be people trying to 79 00:04:19,160 --> 00:04:20,959 push it back. And and the reason I was 80 00:04:20,959 --> 00:04:24,760 bringing up the international stuff is because in Japan which 81 00:04:24,760 --> 00:04:27,800 is a very developed country has some of the best innovative 82 00:04:27,800 --> 00:04:31,520 technologies with so many in so many different facets and 83 00:04:31,560 --> 00:04:35,920 they've had approval and regulation for these stem cells 84 00:04:35,920 --> 00:04:38,080 for over 10 years now since 2014. 85 00:04:38,080 --> 00:04:43,320 So if if you're looking at efficacy and safety, Japanese 86 00:04:43,360 --> 00:04:46,360 are very careful in what they're going to allow their people to 87 00:04:46,360 --> 00:04:49,080 have. China, same thing and Korea as 88 00:04:49,080 --> 00:04:51,200 well. So all these countries are have 89 00:04:51,200 --> 00:04:54,240 been doing them for a long time. So you I can't. 90 00:04:54,400 --> 00:04:56,360 You can't really justify and say it. 91 00:04:56,360 --> 00:04:58,560 It must be dangerous or it must be unsafe if all these other 92 00:04:58,560 --> 00:05:00,560 countries are doing it and offering it to their people. 93 00:05:01,280 --> 00:05:03,080 Yeah, I totally agree. I actually just recorded a 94 00:05:03,080 --> 00:05:05,960 podcast last week with someone talking about Peptide therapy 95 00:05:06,280 --> 00:05:08,760 and it seems like much of the red tape is very similar between 96 00:05:08,760 --> 00:05:12,680 that and gene cell therapy as far as you know the the big 97 00:05:12,680 --> 00:05:16,480 pharma not having figured out how to make the most money from 98 00:05:16,480 --> 00:05:17,280 it. So that's why. 99 00:05:17,280 --> 00:05:20,480 All the yeah that's that's literally what it is and big and 100 00:05:20,720 --> 00:05:23,600 unfortunately we we do use peptides a lot too to combine it 101 00:05:23,600 --> 00:05:26,960 with our cell therapies and and even our gene therapies based 102 00:05:26,960 --> 00:05:31,160 off of peptide. So I'm I'm very saddened when, 103 00:05:31,400 --> 00:05:34,760 when the FDA decided to ban peptides in the US. 104 00:05:34,760 --> 00:05:36,600 Kind of crazy. Yeah, it is. 105 00:05:36,600 --> 00:05:38,080 It is. It is insane. 106 00:05:38,080 --> 00:05:41,080 So for someone listening that is not well versed in peptide 107 00:05:41,080 --> 00:05:44,320 therapy, gene cell therapy, if they're just familiar like hey, 108 00:05:44,320 --> 00:05:47,280 they they have an injury, they go to the doctor, they, you 109 00:05:47,280 --> 00:05:49,480 know, depending on the type of injury, they get some medication 110 00:05:49,480 --> 00:05:52,480 for it, some pain relief, they put them in a cast or something 111 00:05:52,480 --> 00:05:54,800 like that. How is what we're seeing now 112 00:05:54,800 --> 00:05:58,920 with peptides and and cell therapy and gene therapy like 113 00:05:58,920 --> 00:06:01,720 what is that like differentiating itself from 114 00:06:02,000 --> 00:06:04,600 traditional medicine like you were before we started 115 00:06:04,600 --> 00:06:05,920 recording? You're talking about medicine 116 00:06:05,920 --> 00:06:08,240 one point O2, point O3, point O, 4 point O. 117 00:06:08,240 --> 00:06:11,360 Like how does that breakdown? Yeah. 118 00:06:11,360 --> 00:06:16,440 So first, when it comes to musculoskeletal or injuries, the 119 00:06:16,440 --> 00:06:19,360 biggest, the biggest difference is instead of just managing the 120 00:06:19,360 --> 00:06:24,240 pain or because if the pain gets too much, then maybe you cut it 121 00:06:24,240 --> 00:06:27,560 out or you just put people on chronic pain medications. 122 00:06:27,560 --> 00:06:30,080 We're trying to figure out the root cause and trying to see if 123 00:06:30,080 --> 00:06:32,040 we can restore function to that tissue. 124 00:06:32,600 --> 00:06:36,720 So the classic example of this, which we've done many times and 125 00:06:36,720 --> 00:06:39,960 now it's becoming somewhat mainstream is something like 126 00:06:40,000 --> 00:06:43,960 platelet rich plasma PRP where you just take your blood, you 127 00:06:43,960 --> 00:06:46,520 centrifuge it and you concentrate The platelets and 128 00:06:46,520 --> 00:06:49,600 the platelets act like a medication in the sense that 129 00:06:49,600 --> 00:06:52,600 they send a signal to help repair damaged tendons and 130 00:06:52,600 --> 00:06:55,360 muscles. But the the, the biggest issue 131 00:06:55,360 --> 00:06:58,360 right now in this whole field is how strong does the signal need 132 00:06:58,360 --> 00:07:01,240 to be and what's the best signal, what's the best dosing. 133 00:07:01,240 --> 00:07:03,720 And we still haven't figured that out completely, but there 134 00:07:03,720 --> 00:07:07,360 are things we figured out which is that the signal from stem 135 00:07:07,360 --> 00:07:10,880 cells or exosomes which are kind of the soup the stem cells grow 136 00:07:10,880 --> 00:07:14,400 in, are much stronger than PRP. So you can treat a lot more 137 00:07:14,400 --> 00:07:16,640 significant and severe conditions. 138 00:07:17,160 --> 00:07:22,600 And in peptides what they do they they go down at a cellular 139 00:07:22,600 --> 00:07:26,640 level to target specific pathways, which is this whole 140 00:07:26,640 --> 00:07:29,840 idea of precision medicine, which is like, OK, this is kind 141 00:07:29,840 --> 00:07:32,600 of what's wrong with you. So can we correct that as 142 00:07:32,600 --> 00:07:36,040 opposed to just saying take this medication and manage the pain 143 00:07:36,040 --> 00:07:38,280 that way. So if you have someone who has 144 00:07:38,280 --> 00:07:40,680 an acute, let's just say sprain, we're not talking like a 145 00:07:40,680 --> 00:07:42,320 fracture. Obviously, you know, if you have 146 00:07:42,320 --> 00:07:44,480 a fracture, you still need to go to hospital, you still need to 147 00:07:44,480 --> 00:07:47,240 get and that's where acute medicine is great, right. 148 00:07:47,240 --> 00:07:51,000 But if often times there's people in this Gray area where 149 00:07:51,920 --> 00:07:54,600 they might have a minor injury and they want to just get better 150 00:07:54,600 --> 00:07:57,480 as quickly as possible, peptides can really be effective for 151 00:07:57,480 --> 00:07:58,920 that. Like if you haven't if I would 152 00:07:58,920 --> 00:08:01,960 say I'm a sports medicine doctor by training and I would say like 153 00:08:02,160 --> 00:08:06,000 if I had an acute sports medicine injury kit like a first 154 00:08:06,000 --> 00:08:11,080 aid kit it would probably be BPC 157TB four and and maybe CJCI 155 00:08:11,080 --> 00:08:15,040 Pirellin and these are so the last one is a growth hormone 156 00:08:15,040 --> 00:08:17,840 peptide and the other two are both regenerative medicine kind 157 00:08:17,840 --> 00:08:19,960 of peptides the hub with different cellular pathways and 158 00:08:19,960 --> 00:08:22,440 reducing inflammation and creating an environment that 159 00:08:22,440 --> 00:08:25,640 allows your body to heal. And they're very safe in the 160 00:08:25,640 --> 00:08:30,000 sense that the the therapeutic dose and the toxic dose are so 161 00:08:30,000 --> 00:08:32,159 far off that you can't really overdose on them. 162 00:08:32,440 --> 00:08:35,600 And I have clinically I've I think I've had one patient and 163 00:08:35,600 --> 00:08:38,960 hundreds or thousands at this point maybe have side effects to 164 00:08:38,960 --> 00:08:41,200 the peptide which was just like a local allergy reaction but 165 00:08:41,480 --> 00:08:44,600 nothing nothing serious so there's they're so safe. 166 00:08:44,600 --> 00:08:47,800 So it it it doesn't make sense. Again, I mean the whole 167 00:08:47,800 --> 00:08:50,360 regulation thing we talked about, but it's it's this whole 168 00:08:50,360 --> 00:08:55,000 concept which is the regulatory bodies can't keep up with the 169 00:08:55,000 --> 00:08:58,760 acceleration of medicine transitioning and that concept 170 00:08:58,960 --> 00:09:02,440 is basically medicine. One point O was obviously the 171 00:09:02,440 --> 00:09:06,040 old ages basically where they used to do bloodletting and all 172 00:09:06,040 --> 00:09:09,080 sorts of stuff that you know hit in hit prehistorical kind of 173 00:09:09,080 --> 00:09:11,800 times and probably before the 19th or 20th century. 174 00:09:12,120 --> 00:09:15,120 And then we kind of got into modern medicine, which was 19th 175 00:09:15,240 --> 00:09:19,800 and 20th century and which which was obviously revolutionary for 176 00:09:19,800 --> 00:09:23,720 infectious diseases, treated surgery, surgery advanced so 177 00:09:23,720 --> 00:09:25,720 much. We got amazing at treating these 178 00:09:25,760 --> 00:09:29,680 acute illnesses and diseases that used to kill people. 179 00:09:30,080 --> 00:09:33,920 But we didn't realize that the modern environment that we are 180 00:09:33,920 --> 00:09:38,200 making was setting up people for this huge chronic disease 181 00:09:38,200 --> 00:09:41,680 epidemic where you have what's called an evolutionary mismatch 182 00:09:41,680 --> 00:09:44,760 between our genes and the environment that we're in. 183 00:09:44,760 --> 00:09:48,480 And as this mismatch becomes wider due to the convenience of 184 00:09:48,480 --> 00:09:52,320 modern lifestyle, you see an acceleration in chronic diseases 185 00:09:52,320 --> 00:09:55,920 plus all the toxins and there's so many other factors too. 186 00:09:55,920 --> 00:09:58,520 But obviously the modern environment is not designed for 187 00:09:58,520 --> 00:10:02,160 evolutionary bodies which are designed to be in the sun and 188 00:10:02,160 --> 00:10:06,000 move, eat certain minimally processed foods, socialize like 189 00:10:06,000 --> 00:10:09,320 all these things that are basic but unfortunately most of us 190 00:10:09,320 --> 00:10:12,280 don't do that stuff and and that leads to chronic illness. 191 00:10:12,280 --> 00:10:17,200 And so medicine 3 point O is this whole concept kind of first 192 00:10:17,200 --> 00:10:21,920 proposed by Peter TI believe about just trying to prevent 193 00:10:21,920 --> 00:10:26,080 disease using lifestyle and exercise and all these great 194 00:10:26,080 --> 00:10:28,000 things that we know can be beneficial. 195 00:10:29,000 --> 00:10:32,080 But to me I think be given the environment we're in and we kind 196 00:10:32,080 --> 00:10:34,160 of know a lot of people unfortunately the people it's 197 00:10:34,160 --> 00:10:35,680 very hard to get people to change. 198 00:10:36,000 --> 00:10:39,080 So what I see is medicine 4 point O, which is kind of what 199 00:10:39,080 --> 00:10:42,360 we're trying to bring now to the platform, which is giving your 200 00:10:42,360 --> 00:10:45,440 bodies the tools using cell and gene therapy to be more 201 00:10:45,440 --> 00:10:48,400 resilient and to hopefully create more behavior change and 202 00:10:48,400 --> 00:10:51,320 increase health span. And the perfect example of this 203 00:10:52,240 --> 00:10:55,200 is, is our gene therapy product called falstatin. 204 00:10:55,200 --> 00:10:57,840 Gene therapy. Falstatin has been around for 205 00:10:57,840 --> 00:11:01,720 two decades, but it's a peptide with a very short half life and 206 00:11:01,720 --> 00:11:04,880 it inhibits myostatin, which means it can increase muscle 207 00:11:04,880 --> 00:11:08,000 mass but it also decreases systemic inflammation which 208 00:11:08,000 --> 00:11:13,880 allows to decrease aging, it increases energy vitality. 209 00:11:14,080 --> 00:11:17,720 We've seen people D age their body by, you know, 20 plus years 210 00:11:17,720 --> 00:11:20,160 on based off the epigenetic testing. 211 00:11:20,400 --> 00:11:21,880 Does that mean they're live more than 20 years? 212 00:11:21,880 --> 00:11:24,320 We don't know. But what we can say is their 213 00:11:24,320 --> 00:11:26,720 health span will increase. And increasing their health 214 00:11:26,720 --> 00:11:29,400 span, which means they can exercise and do all the good 215 00:11:29,400 --> 00:11:32,240 stuff for a longer period of time, ultimately is gonna give 216 00:11:32,240 --> 00:11:35,800 you more, not only better quality of life, but more 217 00:11:35,800 --> 00:11:38,320 longevity. Because I think you and I both 218 00:11:38,320 --> 00:11:40,440 know and probably most people know now who are probably 219 00:11:40,440 --> 00:11:43,600 listening to your show muscle is kind of the organ of longevity. 220 00:11:43,600 --> 00:11:46,200 And the more you can maintain that muscle mass through 221 00:11:46,200 --> 00:11:48,000 lifestyle, the better off you're going to be. 222 00:11:48,000 --> 00:11:50,160 And that's what these cell and gene therapies can really do. 223 00:11:50,680 --> 00:11:53,480 Totally agree man. Is there any controversy around 224 00:11:53,480 --> 00:11:57,320 this outside of just the financial concern held by Big 225 00:11:57,320 --> 00:12:01,760 Pharma and traditional medicine? Like is there ethical concerns 226 00:12:01,760 --> 00:12:05,080 or safety concerns long term? Like has there been any data to 227 00:12:05,080 --> 00:12:07,120 back that up? I mean, I guess we're kind of on 228 00:12:07,120 --> 00:12:08,880 the cutting edge a lot of this stuff so that there wouldn't be 229 00:12:08,880 --> 00:12:10,640 any long term data. I don't, I don't imagine. 230 00:12:11,440 --> 00:12:13,760 Yeah, I mean, I mean that's where you have to come back to 231 00:12:14,000 --> 00:12:16,440 first principles and understanding kind of the 232 00:12:16,440 --> 00:12:18,840 fundamental biology and mechanistic action of these 233 00:12:18,840 --> 00:12:22,160 things. And that's why something like 234 00:12:22,800 --> 00:12:26,240 stem cells, so specifically mesenchymal stem cells, which is 235 00:12:26,560 --> 00:12:29,680 just an embryological term to denote kind of their origin. 236 00:12:29,880 --> 00:12:32,600 But these are the ones we're using and they've been around 237 00:12:32,600 --> 00:12:34,720 for like 20 years. So it's not new. 238 00:12:34,720 --> 00:12:36,560 So there is a lot of studies and data on it. 239 00:12:36,560 --> 00:12:39,480 What's new is just the manufacturing and improving the 240 00:12:39,480 --> 00:12:42,720 cell viability and quality. And now we're getting into the 241 00:12:42,720 --> 00:12:45,680 second generation stem cells, which again was probably 242 00:12:45,680 --> 00:12:47,280 discovered. They're called induced 243 00:12:47,280 --> 00:12:51,360 pluripotent stem cells or Yamanaka stem cells, kind of the 244 00:12:51,360 --> 00:12:54,400 Nobel Prize winner Professor Yamanaka named them after 245 00:12:54,400 --> 00:12:56,720 himself. But the the medical name is 246 00:12:56,720 --> 00:12:59,240 induced pluripotent stem cells and they're basically cellular 247 00:12:59,240 --> 00:13:02,200 reprogrammed using these transcription factors. 248 00:13:02,200 --> 00:13:04,520 And you can take any cell in your body and turn it back into 249 00:13:04,520 --> 00:13:06,600 a baby stem cell, which is really cool. 250 00:13:06,600 --> 00:13:09,760 But that even that has been around since I think late 2000s. 251 00:13:09,760 --> 00:13:11,160 So it's not. So I mean if you think about it, 252 00:13:11,160 --> 00:13:12,840 that's still over almost 15 years. 253 00:13:13,080 --> 00:13:16,040 So it's not that that new is just what's new is I would say 254 00:13:16,040 --> 00:13:18,760 is the application understanding how we're using it now more and 255 00:13:18,760 --> 00:13:21,680 more and kind of the potential. We didn't. 256 00:13:21,680 --> 00:13:25,720 I don't think anyone realized that when stem cells, 257 00:13:25,720 --> 00:13:29,120 mesenchymal stem cells were first discovered in in 1992 by 258 00:13:29,480 --> 00:13:32,320 Professor Arnold Kaplan, I don't think, I don't think he even 259 00:13:32,320 --> 00:13:35,440 realized how much potential these things had for so many 260 00:13:35,520 --> 00:13:39,000 various conditions. So what we're realizing now is 261 00:13:39,000 --> 00:13:42,600 these things can be programmed similar to how drugs release a 262 00:13:43,080 --> 00:13:44,840 therapeutic dose. If we just have to figure out 263 00:13:44,840 --> 00:13:47,760 the right dosing and right programming for these cells to 264 00:13:47,760 --> 00:13:50,880 get what we want them to do and we can treat a lot of diseases. 265 00:13:50,880 --> 00:13:52,720 So it's really exciting for that reason. 266 00:13:52,720 --> 00:13:57,040 So, so to answer your question in in, in short, the risk of 267 00:13:57,080 --> 00:14:01,200 vasectable stem cells and IPSCSI think is very minimal because if 268 00:14:01,200 --> 00:14:04,400 it's steady for a long time, the biggest risk with IPSCS which 269 00:14:04,400 --> 00:14:07,440 are those Yamadaka ones is because you're taking them back 270 00:14:07,440 --> 00:14:09,920 into an embryological state there they have too much 271 00:14:09,920 --> 00:14:11,880 stemness, so they can actually turn into tumors. 272 00:14:12,160 --> 00:14:17,000 But we have a technology that has a gene edit which prevents 273 00:14:17,000 --> 00:14:18,720 these IPS CS from turning into tumors. 274 00:14:18,720 --> 00:14:21,480 So it's it's a very sophisticated technology where 275 00:14:21,480 --> 00:14:24,040 you can actually program these cells and you can build in these 276 00:14:24,040 --> 00:14:26,360 safety mechanisms. And the same thing with our gene 277 00:14:26,360 --> 00:14:28,680 therapy. The we're the only company in 278 00:14:28,680 --> 00:14:32,520 the world that has a reversible gene therapy and that's gives us 279 00:14:32,520 --> 00:14:35,760 a very unique safety point because traditionally gene 280 00:14:35,760 --> 00:14:39,600 therapies were viral vectors and viral vectors, you can't reverse 281 00:14:39,600 --> 00:14:42,080 them. And and unlike CRISPR, which 282 00:14:42,240 --> 00:14:44,800 edits your genes, this is not editing your genes. 283 00:14:44,800 --> 00:14:48,360 All it's doing is inserting A plasmid which just produces more 284 00:14:48,360 --> 00:14:50,920 of the falstatin which goes into your circulatory system. 285 00:14:50,920 --> 00:14:53,960 So both of the things that I, at least the things I'm working 286 00:14:53,960 --> 00:14:56,280 with, I'm very comfortable in their safety because I. 287 00:14:56,280 --> 00:14:58,800 And once you understand the mechanism, you're kind of like, 288 00:14:58,800 --> 00:15:00,960 oh, OK, well, I mean it's reversible. 289 00:15:00,960 --> 00:15:03,080 Let's just say for the worst case scenario, you want it out 290 00:15:03,080 --> 00:15:05,360 of your body, you just take an antibiotic and it's out of your 291 00:15:05,360 --> 00:15:07,360 body. So and that that's never 292 00:15:07,360 --> 00:15:09,440 happened to date. Like no one's wanted to have 293 00:15:09,440 --> 00:15:10,960 their body because everyone feels pretty great on it. 294 00:15:10,960 --> 00:15:13,720 But let's just say you wanted it for whatever reason, it it has 295 00:15:13,720 --> 00:15:15,240 that safety mechanism built into it. 296 00:15:15,760 --> 00:15:17,520 Gotcha. And the main the main mechanism 297 00:15:17,520 --> 00:15:20,600 of action is the is the anti-inflammatory effect when 298 00:15:20,600 --> 00:15:22,400 injected in a localized region, right? 299 00:15:23,360 --> 00:15:28,160 For falostatin, yeah, it's actually that's one effect. 300 00:15:28,160 --> 00:15:30,360 But the other effect which I would say is equally as 301 00:15:30,360 --> 00:15:32,400 important is the inhibition of myostatin. 302 00:15:33,120 --> 00:15:37,080 Because follow statin as the circulatory blood levels go up, 303 00:15:37,320 --> 00:15:40,520 it has an antagonistic relationship to myostatin. 304 00:15:40,520 --> 00:15:43,720 So it inhibits myostatin, which means you can put on muscle 305 00:15:43,720 --> 00:15:45,240 easier. And I I call it a body 306 00:15:45,240 --> 00:15:48,200 recomposition tool because it actually makes fat loss easier 307 00:15:48,200 --> 00:15:51,280 because it improves metabolism and then it also makes muscle 308 00:15:51,280 --> 00:15:52,480 gain easier. So it's pretty cool. 309 00:15:53,160 --> 00:15:55,480 Probably improves metabolism because of the increase in lean 310 00:15:55,480 --> 00:15:57,600 tissue, I would imagine, right? Exactly. 311 00:15:57,600 --> 00:16:01,600 And also we know that chronic inflammation when you have pro 312 00:16:01,600 --> 00:16:04,360 inflammatory cytokines, it can affect the cellular pathways 313 00:16:04,360 --> 00:16:07,000 that regulate metabolism. So by clearing up some 314 00:16:07,000 --> 00:16:10,080 inflammation, you're improving your metabolism in that sense as 315 00:16:10,080 --> 00:16:11,760 well? I'd love to kind of dive into 316 00:16:11,760 --> 00:16:13,680 some use case scenarios here because most people when they 317 00:16:13,680 --> 00:16:15,880 hear stem cells, they're probably thinking OK you have a 318 00:16:15,880 --> 00:16:18,640 meniscus tear, you have some soft tissue damage, you inject 319 00:16:18,640 --> 00:16:23,120 stem cells there around the knee and that promotes healthy tissue 320 00:16:23,120 --> 00:16:25,080 growth, anti inflammation there in that region. 321 00:16:25,080 --> 00:16:26,680 What are some other use case scenarios here? 322 00:16:27,840 --> 00:16:30,600 Yeah, I think, I think what we're understanding now is I 323 00:16:30,600 --> 00:16:33,840 mean there was a paper that just came out there's so many use 324 00:16:33,840 --> 00:16:36,600 cases. I I it it sounds kind of crazy, 325 00:16:36,600 --> 00:16:39,680 but I would say almost every chronic disease, you know from 326 00:16:39,680 --> 00:16:43,320 dementia, Alzheimer's, multiple sclerosis, Parkinson's disease. 327 00:16:43,320 --> 00:16:45,400 There's a trial that came out this year which was really put 328 00:16:45,400 --> 00:16:51,720 people into remission multiple sclerosis and and a chronic 329 00:16:51,960 --> 00:16:55,080 inflammatory bowel disease, rheumatoid arthritis, lupus. 330 00:16:55,320 --> 00:16:58,840 The problem is because there's now stem cells is such a broad 331 00:16:58,840 --> 00:17:00,720 word and there's so many different type of cell 332 00:17:00,720 --> 00:17:02,880 therapies. So that's that's where it's 333 00:17:02,880 --> 00:17:04,720 getting sophisticated. So there's different cell 334 00:17:04,720 --> 00:17:07,720 therapies now we can manufacture for all these different 335 00:17:07,720 --> 00:17:10,119 conditions. So my favorite use for it and 336 00:17:10,119 --> 00:17:13,400 the use case that I see the most benefit for is definitely with 337 00:17:13,400 --> 00:17:16,920 chronic diseases and chronic inflammatory conditions such as 338 00:17:17,520 --> 00:17:19,640 rheumatoid arthritis or inflammatory bowel disease. 339 00:17:19,640 --> 00:17:22,880 And where we do intravenous stem cells and it actually it does 340 00:17:22,880 --> 00:17:26,000 something called macrophage phenotyping which is basically 341 00:17:26,000 --> 00:17:29,480 it's shifting how the macrophages which are these 342 00:17:30,240 --> 00:17:33,640 white blood cells part of your immune system is shifting how 343 00:17:33,640 --> 00:17:36,560 they express their signals from pro inflammatory to 344 00:17:36,560 --> 00:17:39,320 anti-inflammatory. This is called immunomodulation 345 00:17:39,320 --> 00:17:44,640 and this immunomodulatory effect is by far the most beneficial 346 00:17:44,640 --> 00:17:47,400 part of putting stem cells intravenously. 347 00:17:47,400 --> 00:17:50,040 And of course when you're modulating the immune system, 348 00:17:50,200 --> 00:17:53,040 it's going to have anti aging and longevity benefits because 349 00:17:53,040 --> 00:17:56,200 we all know inflammation and chronic inflammation is one of 350 00:17:56,200 --> 00:17:58,720 the main drivers of aging. So that's why people use it for 351 00:17:58,720 --> 00:18:01,400 anti aging and longevity. But I really like the use case 352 00:18:01,400 --> 00:18:04,680 of the IV because I see just so many broad applications for it 353 00:18:04,680 --> 00:18:06,360 do. You see people starting to do 354 00:18:06,360 --> 00:18:08,400 this like prophylactically, like, even if they don't have 355 00:18:08,400 --> 00:18:10,160 any known. Oh yeah, all the time. 356 00:18:10,520 --> 00:18:14,360 Yeah, yeah, it's, it's obviously it's the cost has come down I 357 00:18:14,360 --> 00:18:17,960 think, you know, I think couple years ago it was almost like 358 00:18:17,960 --> 00:18:19,560 five years ago, it's probably double the price. 359 00:18:19,560 --> 00:18:21,160 So it's come down by half I would say. 360 00:18:21,600 --> 00:18:24,120 So I think it's becoming a lot more affordable and I think in 361 00:18:24,120 --> 00:18:25,960 another five years they'll be probably half the price. 362 00:18:26,240 --> 00:18:28,880 So I I can, I can that and that's why I think in 10 years 363 00:18:28,880 --> 00:18:32,360 when this is you know one or $2000 or something like that or 364 00:18:32,360 --> 00:18:36,720 a couple $1000 for an IV I I feel like and that lasts for 18 365 00:18:36,720 --> 00:18:39,200 to 24 months you could I could see millions of people doing it 366 00:18:39,200 --> 00:18:40,720 you know. And that is something that they 367 00:18:40,720 --> 00:18:43,600 would probably have to do just independently or would they be 368 00:18:43,600 --> 00:18:44,920 able to go to their insurance you think? 369 00:18:45,600 --> 00:18:48,360 That's I mean that and the goal is insurance but that's to me 370 00:18:48,360 --> 00:18:51,600 that's a 20 year timeline because you're playing that's a 371 00:18:51,600 --> 00:18:55,160 long game, right And that is the game I think we we're in back in 372 00:18:55,160 --> 00:18:57,640 my mind that I'd love to see and that's part of the reason we're 373 00:18:57,640 --> 00:19:00,320 doing our clinical trials and everything but but I do think 374 00:19:00,320 --> 00:19:03,720 that'll take that'll take it as a multi decade endeavor But in 375 00:19:03,720 --> 00:19:06,160 the meantime I think this can become more accessible and 376 00:19:06,160 --> 00:19:09,280 affordable as obviously the early adopters are paving the 377 00:19:09,280 --> 00:19:11,800 way for regular people to kind of afford it. 378 00:19:12,200 --> 00:19:15,440 Yeah, cuz you see a lot of people, well known people, elite 379 00:19:15,440 --> 00:19:19,600 level athletes, Rogan, Tony, Robbins, these people are using 380 00:19:19,760 --> 00:19:22,920 this technology now how are they getting access to it? 381 00:19:22,920 --> 00:19:25,480 They just they have localized. Well yeah. 382 00:19:25,480 --> 00:19:30,600 Tony's a patient of mine so he he he, so we've we've worked on 383 00:19:30,600 --> 00:19:34,160 him and fixed up his shoulder and did the fall stab for him. 384 00:19:34,160 --> 00:19:36,120 He's going to be making a testimonial for me so I can talk 385 00:19:36,120 --> 00:19:39,080 about it and we have a picture together on Instagram but he's 386 00:19:39,280 --> 00:19:42,440 but yeah so I he obviously comes to see me he'll he'll have to. 387 00:19:43,600 --> 00:19:47,480 He usually we do it in Mexico, Los Cabos that's where and we 388 00:19:47,480 --> 00:19:50,600 also have places in Dubai and Europe and then we have one in 389 00:19:50,760 --> 00:19:53,040 Bahamas going to open it up next year. 390 00:19:53,040 --> 00:19:56,240 So we have different off site locations and I think medical 391 00:19:56,240 --> 00:19:58,560 tourism's just going to continue to grow because like you said 392 00:19:58,560 --> 00:20:02,320 people are seeing you know the Tony Robbins of the world and 393 00:20:02,320 --> 00:20:05,000 and those people doing it and more and more athletes. 394 00:20:05,200 --> 00:20:07,200 So people are starting to wonder and be like why are all these? 395 00:20:08,000 --> 00:20:11,520 Rich and famous and successful people and amazing ** athletes 396 00:20:11,520 --> 00:20:13,920 doing it. So there's got to be a reason, 397 00:20:13,920 --> 00:20:15,920 right? And so people start looking into 398 00:20:15,920 --> 00:20:18,200 it and they want a lot of people who have the means to do it. 399 00:20:18,200 --> 00:20:21,680 Don't want just like Sub Park medical care that you can get in 400 00:20:21,880 --> 00:20:24,680 US if you have access to better technology. 401 00:20:25,000 --> 00:20:27,880 And this is all, I guess there's just less bureaucratic red tape 402 00:20:27,880 --> 00:20:29,120 to jump through in these other countries. 403 00:20:29,120 --> 00:20:30,320 That's why it's accessible there. 404 00:20:31,160 --> 00:20:34,200 Yeah, and and they're not corrupted. 405 00:20:34,240 --> 00:20:38,120 It's, I mean just the truth by political companies, I mean like 406 00:20:38,360 --> 00:20:43,040 the Middle East, I mean Japan and Dubai are perfect examples 407 00:20:43,200 --> 00:20:47,040 because they're, they're developed countries obviously 408 00:20:47,040 --> 00:20:49,960 with like especially Japan has a really like robust economy. 409 00:20:49,960 --> 00:20:52,520 Like it's not like it's like a third world country there, 410 00:20:52,520 --> 00:20:55,840 right. So they're obviously doing it 411 00:20:55,840 --> 00:20:57,800 for a reason and they're allowing their people to have 412 00:20:57,800 --> 00:21:00,840 access to this because they believe it's good for them. 413 00:21:01,840 --> 00:21:05,360 What is the as a bodybuilder? I'm curious what is the rate of 414 00:21:05,360 --> 00:21:08,160 lean tissue growth using something like this therapy as 415 00:21:08,160 --> 00:21:11,280 opposed to those that go the route of anabolic steroids for 416 00:21:11,280 --> 00:21:12,760 instance? Yeah, It's definitely not going 417 00:21:12,760 --> 00:21:15,040 to make you blow up like Anabolics, but Anabolics 418 00:21:15,040 --> 00:21:17,920 obviously have so many other side effects and they accelerate 419 00:21:17,920 --> 00:21:21,920 aging and whereas this slows down aging, this is going to 420 00:21:21,920 --> 00:21:23,840 help. Typically I'm, I'm a natural 421 00:21:23,840 --> 00:21:26,280 bodybuilder myself, so I can tell you my experience and based 422 00:21:26,280 --> 00:21:28,240 off our clinical trial, I can give you some info on that too. 423 00:21:28,240 --> 00:21:31,560 But for myself, for someone who's been working for over 10 424 00:21:31,560 --> 00:21:36,640 years, it it, it can help you to gain about 15 to 20 point 20% 425 00:21:36,640 --> 00:21:38,320 strength, which is pretty significant if we've been 426 00:21:38,320 --> 00:21:41,080 training a long time. And then that strength increase 427 00:21:41,080 --> 00:21:43,960 obviously you can do more volume and then you can put on more 428 00:21:43,960 --> 00:21:46,400 muscle and you're not going to put on like you know if you're 429 00:21:46,400 --> 00:21:48,960 trying to put on, if you're going in this calorie surplus, 430 00:21:48,960 --> 00:21:52,280 you can put on, you know maybe two 3 lbs / 6 months type of 431 00:21:52,280 --> 00:21:54,160 thing. But typically it's nothing 432 00:21:54,160 --> 00:21:55,920 crazy. But there are some people who 433 00:21:55,920 --> 00:21:58,000 are hyper responders that we had in the clinical trial. 434 00:21:58,280 --> 00:22:01,000 We had some natural bodybuilders who put on 6 to 8 lbs of muscle, 435 00:22:01,000 --> 00:22:02,520 and this was confirmed by DEXA scan. 436 00:22:03,160 --> 00:22:05,840 And then we had some people who weren't working out at all and 437 00:22:05,840 --> 00:22:09,880 they still gained like one 1 1/2 lbs of muscle and they lost body 438 00:22:09,880 --> 00:22:12,960 fat. So there's so there's definitely 439 00:22:13,520 --> 00:22:17,040 a benefit even if you're not exercising, but if you exercise, 440 00:22:17,040 --> 00:22:18,400 you're obviously going to get more out of it. 441 00:22:18,680 --> 00:22:21,000 I would imagine that would still probably be frowned upon within 442 00:22:21,000 --> 00:22:22,440 natural bodybuilding federations. 443 00:22:22,440 --> 00:22:24,040 They would probably still view that as like. 444 00:22:25,160 --> 00:22:26,880 A Yeah, I've had. I've had this discussion with 445 00:22:26,880 --> 00:22:29,120 Jeff Nippert and Alan Aragon. I don't know if you know who 446 00:22:29,120 --> 00:22:30,600 they are. Yeah. 447 00:22:30,600 --> 00:22:32,480 So both of them. I mean it's an interesting 448 00:22:32,480 --> 00:22:35,400 discussion because we we have there isn't there definitely is 449 00:22:35,400 --> 00:22:37,000 not a consensus in the community. 450 00:22:37,000 --> 00:22:41,520 I think some people think that it's similar to BPC and it is a 451 00:22:41,520 --> 00:22:43,200 peptide technically. So it's just helping with 452 00:22:43,200 --> 00:22:46,200 healing and recovery. Yes it is giving you some sort 453 00:22:46,200 --> 00:22:48,640 of advantage but so is creative. I mean, look at creatine. 454 00:22:48,640 --> 00:22:51,800 Like, I I don't know where you draw the line and between what's 455 00:22:51,800 --> 00:22:56,160 natural and what's unnatural, because creatine has obviously 456 00:22:56,160 --> 00:22:58,080 benefits too. It's an ergogenic aid, Caffeine 457 00:22:58,080 --> 00:23:01,800 as well. And so I don't know what I think 458 00:23:01,800 --> 00:23:06,120 in this era, modern era peptides in my opinion shouldn't be 459 00:23:06,120 --> 00:23:09,440 considered illegal when it comes to sports performance. 460 00:23:09,680 --> 00:23:13,240 But many federations have banned them, which is a shame and which 461 00:23:13,240 --> 00:23:16,040 is why I like the fact that Peter Thiel and these guys are 462 00:23:16,040 --> 00:23:17,880 getting, I don't know if you've seen that thing about starting 463 00:23:17,880 --> 00:23:21,960 enhanced. Enhanced, Yeah, I'm a I'm a huge 464 00:23:22,000 --> 00:23:23,840 proponent of that. So I'm going to be one of the 465 00:23:23,840 --> 00:23:26,400 doctors. I think that's a great idea. 466 00:23:27,320 --> 00:23:30,560 So it's it's it's the way things should be anyway, because most 467 00:23:30,560 --> 00:23:33,440 people do use this stuff and they just skirt testing and they 468 00:23:33,440 --> 00:23:35,960 know how to get around it. Yeah, I mean totally independent 469 00:23:35,960 --> 00:23:39,040 of the the natural bodybuilding federations and sports 470 00:23:39,040 --> 00:23:40,880 performance in general. Like, I'm super excited about 471 00:23:40,880 --> 00:23:43,640 this from an aging and longevity standpoint. 472 00:23:43,640 --> 00:23:46,800 Like when you have an elderly individual that would most 473 00:23:46,800 --> 00:23:49,440 definitely benefit from it and they're not trying to compete, 474 00:23:50,280 --> 00:23:51,760 you know, for cash prizes or anything. 475 00:23:51,760 --> 00:23:54,160 Like I can't understand why there would be so much pushback 476 00:23:54,160 --> 00:23:57,680 for that demographic. Yeah, and that's why we we 477 00:23:57,680 --> 00:24:01,840 believe a country like we're doing our phase two trial for 478 00:24:01,840 --> 00:24:06,040 sarcopenia which is age-related muscle loss. 479 00:24:06,440 --> 00:24:08,480 Sometimes it can be, even at younger ages, but generally it's 480 00:24:08,480 --> 00:24:13,760 with aging and sarcopenia is probably a bigger public health 481 00:24:13,760 --> 00:24:16,760 concern than osteopenia or osteoporosis, which is low bone 482 00:24:16,760 --> 00:24:18,400 density but doesn't get talked about enough. 483 00:24:18,400 --> 00:24:21,080 And sarcopenia, there's no treatment for it. 484 00:24:21,560 --> 00:24:24,160 So this will be the hopefully the world's first treatment for 485 00:24:24,160 --> 00:24:25,800 sarcopenia and we want to get that. 486 00:24:25,880 --> 00:24:27,960 And the goal for that is to eventually have insurance 487 00:24:27,960 --> 00:24:30,600 companies cover it for that, for that indication, especially with 488 00:24:30,600 --> 00:24:33,520 the aging population. And that's why Japan's in our 489 00:24:33,520 --> 00:24:36,800 sight and because we believe Japan will really love the 490 00:24:36,800 --> 00:24:39,400 treatment because obviously they have a really aging population, 491 00:24:39,400 --> 00:24:42,000 so. What about something like 492 00:24:42,000 --> 00:24:44,960 diabetes? How would this be applicable for 493 00:24:44,960 --> 00:24:47,360 those suffering with diabetes? Yeah. 494 00:24:47,360 --> 00:24:49,960 Well, there's two types, right? Type one, type 2. 495 00:24:50,280 --> 00:24:54,000 So type 2, as most people probably know, is related to 496 00:24:54,000 --> 00:24:57,440 hyperinsulinemia, which means you have persistent insulin 497 00:24:57,440 --> 00:25:00,160 levels because you become resistant, because you're 498 00:25:01,000 --> 00:25:04,040 because of the blood sugar levels becoming persistently 499 00:25:04,040 --> 00:25:07,640 high, not exercising, all the lifestyle stuff, stress, sleep, 500 00:25:07,640 --> 00:25:09,080 there's so many things that can affect it. 501 00:25:09,320 --> 00:25:11,760 And over time, your cells just don't respond to the insulin 502 00:25:11,760 --> 00:25:13,720 signal. And so your body has to produce 503 00:25:13,720 --> 00:25:15,840 more and more insulin. And this, this is called insulin 504 00:25:15,840 --> 00:25:18,360 resistance. And then that insulin resistance 505 00:25:18,360 --> 00:25:21,400 leads to chronic inflammation. And that chronic inflammation is 506 00:25:21,400 --> 00:25:24,000 what kind of leads to that degradation of health and 507 00:25:24,160 --> 00:25:26,760 cardiovascular disease and everything else that comes with 508 00:25:26,760 --> 00:25:29,360 inflammation. And that is so the way we treat 509 00:25:29,360 --> 00:25:32,720 that because if you think about inflammation as a root cause is 510 00:25:32,720 --> 00:25:35,200 by we talked about how intravenous stem cells have a 511 00:25:35,200 --> 00:25:37,400 benefit. So we we can do intravenous stem 512 00:25:37,400 --> 00:25:39,680 cells and then we also inject the stem cells directly into the 513 00:25:39,680 --> 00:25:43,800 pancreas, which can help to reduce the inflammation in the 514 00:25:43,800 --> 00:25:47,720 organs as well and allow the body to resensitize kind of to 515 00:25:47,720 --> 00:25:50,040 insulin. And so we, we've seen people get 516 00:25:50,040 --> 00:25:53,880 off if they're on insulin or medications, We see the blood 517 00:25:53,880 --> 00:25:58,320 sugar improved dramatically with just regular umbilical cord stem 518 00:25:58,320 --> 00:26:01,440 cells done through this method. And there's a paper that was 519 00:26:01,440 --> 00:26:03,080 published actually from India this year too. 520 00:26:03,800 --> 00:26:07,680 And they showed that same type of results with I think 40 or 50 521 00:26:07,680 --> 00:26:10,680 patients that were able to get off insulin by through this 522 00:26:10,680 --> 00:26:14,520 method. And for type 1, which is more 523 00:26:14,520 --> 00:26:16,800 complicated because there's an autoimmune component and it 524 00:26:16,800 --> 00:26:19,720 tends to be genetic. But what's being worked on for 525 00:26:19,720 --> 00:26:22,680 that and we're we're working on this as well is creating those 526 00:26:22,680 --> 00:26:26,240 genetically engineered cells but creating beta islet cells. 527 00:26:26,600 --> 00:26:30,040 Beta islet cells are the cells that produce insulin and so you 528 00:26:30,040 --> 00:26:35,000 can transplant them via infusion into the pancreas and basically 529 00:26:35,160 --> 00:26:37,600 regrow new islet cells to produce insulin. 530 00:26:37,600 --> 00:26:40,000 But you have to create an environment so the body doesn't 531 00:26:40,000 --> 00:26:42,720 attack itself. So that's the clinical trial 532 00:26:42,720 --> 00:26:45,040 we're going to be doing is kind of combining it with the 533 00:26:45,040 --> 00:26:48,280 intravenous stem cells and something called FMT, which is 534 00:26:48,280 --> 00:26:51,640 fecal microbial transplant for the microbiome and a few other 535 00:26:51,840 --> 00:26:55,400 peptides and bio regulators to help support the immune system 536 00:26:55,400 --> 00:26:59,160 and the thymus gland to basically reboot the immune 537 00:26:59,160 --> 00:27:02,480 system and then transplant new beta islets into the pancreas. 538 00:27:02,480 --> 00:27:03,960 So that's the clinical trial we'll be doing. 539 00:27:03,960 --> 00:27:06,480 It'll be starting next year. There's already a company called 540 00:27:06,480 --> 00:27:09,680 Vertex that has done beta islet cells successfully. 541 00:27:09,840 --> 00:27:12,320 But the problem was the patients have to go on immunosuppressants 542 00:27:12,320 --> 00:27:14,960 because of the the cells that they used. 543 00:27:14,960 --> 00:27:18,200 Our cells will not have the need for immunosuppressants. 544 00:27:18,200 --> 00:27:20,680 So we're hoping we'll have a positive result. 545 00:27:20,680 --> 00:27:22,760 I think we will. And if we do, obviously it'll be 546 00:27:22,760 --> 00:27:25,280 pretty revolutionary for people with type one diabetes. 547 00:27:25,840 --> 00:27:28,200 No, 100% as a treatment like that, something that would also 548 00:27:28,200 --> 00:27:31,960 be administered like on a 1824 month basis or more frequently. 549 00:27:32,720 --> 00:27:35,280 No, it's meant to be permanent because we're in grafting, we're 550 00:27:35,280 --> 00:27:37,440 in grafting new cells that are going to transplant. 551 00:27:38,280 --> 00:27:41,040 It's the same thing with the Parkinson's disease trial they 552 00:27:41,040 --> 00:27:43,200 did this year. They use those IPSC cells I was 553 00:27:43,200 --> 00:27:47,120 talking about and they differentiate them into dopamine 554 00:27:47,160 --> 00:27:49,680 producing neurons and they transplant them surgically into 555 00:27:49,680 --> 00:27:53,920 the claudate nucleus or cotamputamine into the brain 556 00:27:53,920 --> 00:27:57,480 part where the dopamine neurons get degenerated in Parkinson's. 557 00:27:57,480 --> 00:28:00,760 And so you're actually engrafting new cells and those 558 00:28:00,760 --> 00:28:04,920 new cells produce dopamine and so you've effectively cured. 559 00:28:05,240 --> 00:28:07,240 I never like to use the word cure, cause the medicine, you 560 00:28:07,240 --> 00:28:09,160 know, cured is. It's hard to say, 'cause that's, 561 00:28:09,400 --> 00:28:10,520 you know, sounds too good to be true. 562 00:28:10,520 --> 00:28:12,600 But let's just say in remission you're putting patients into 563 00:28:12,600 --> 00:28:14,960 remission effectively after the treatment. 564 00:28:15,680 --> 00:28:16,880 That's just with a single treatment. 565 00:28:16,880 --> 00:28:19,880 Wow that that's insane. That seems much less profitable 566 00:28:19,880 --> 00:28:22,600 than a consistent. Exactly, it's just. 567 00:28:22,640 --> 00:28:25,640 Medication or constant insulin prescriptions. 568 00:28:26,080 --> 00:28:28,360 So yeah, that's the hard part, man. 569 00:28:28,360 --> 00:28:32,680 It's unfortunate there has to be so much finance focused around 570 00:28:32,680 --> 00:28:36,640 treatment, but I mean, for the well-being of the patient, this 571 00:28:36,640 --> 00:28:39,080 seems like the way to go. Yeah. 572 00:28:39,080 --> 00:28:43,240 And and that's why I think the reality is as as more and more 573 00:28:43,240 --> 00:28:46,800 of those, the stuff that we, we explore and if we're able to 574 00:28:46,800 --> 00:28:49,560 pull it off, I think there's going to be a lot of negative 575 00:28:49,840 --> 00:28:51,480 media and negative press around it. 576 00:28:51,480 --> 00:28:53,800 I mean, there's already some about our gene therapy company, 577 00:28:54,360 --> 00:28:58,600 but it's unfortunate. I think I, I always equate it to 578 00:28:58,600 --> 00:29:01,000 what Tesla went through. Tesla was the most shortest 579 00:29:01,000 --> 00:29:04,240 stock in history. At one point it was 33% shorted 580 00:29:04,560 --> 00:29:07,000 which means the hedge funds were trying to drive it under the 581 00:29:07,000 --> 00:29:10,120 ground and because they didn't have because they were so 582 00:29:10,120 --> 00:29:12,360 shorted, they can't. It's harder to raise cash and if 583 00:29:12,360 --> 00:29:15,520 you have more cash flow it makes it harder to run a business and 584 00:29:15,520 --> 00:29:17,320 grow. And so they almost went bankrupt 585 00:29:17,320 --> 00:29:19,240 and. And but why was that? 586 00:29:19,240 --> 00:29:23,160 It was because the oil industry really wanted them to fail and 587 00:29:23,160 --> 00:29:25,160 they did not want them to succeed and they did everything 588 00:29:25,160 --> 00:29:27,240 they could and all the media outlets and everything kept 589 00:29:27,240 --> 00:29:29,760 saying sell, sell sell. Tesla's going to go bankrupt and 590 00:29:30,560 --> 00:29:34,560 you know, after 2020 they their stock 10 or 20X and there was 591 00:29:34,560 --> 00:29:35,720 something called a short squeeze. 592 00:29:35,720 --> 00:29:39,400 And so I saw that unfold as as an investor, early investor in 593 00:29:39,400 --> 00:29:42,040 Tesla. And so I I I expect the same 594 00:29:42,040 --> 00:29:44,920 thing with this stuff. How do you stay optimistic, kind 595 00:29:44,920 --> 00:29:47,000 of being on the tip of the spear with it, but seeing all this 596 00:29:47,000 --> 00:29:52,440 push back? I think because honestly it's 597 00:29:52,440 --> 00:29:55,440 it's as silly as it sounds. I think it's because of the 598 00:29:55,560 --> 00:29:58,880 modern era we're in. If we didn't have social media, 599 00:29:59,000 --> 00:30:01,680 there'd be like 0 hope because then then then the narrative is 600 00:30:01,680 --> 00:30:04,400 all controlled by like 1 entity essentially which is mainstream 601 00:30:04,400 --> 00:30:06,080 media. And they all more or less have 602 00:30:06,080 --> 00:30:10,280 the same people behind them and kind of they want to push 603 00:30:10,280 --> 00:30:14,080 stories in a certain way. But because of because of social 604 00:30:14,080 --> 00:30:17,920 media they can't really stop it and and and to the extent that 605 00:30:17,920 --> 00:30:22,200 they'll go where you if you if you put stem cells on a Google 606 00:30:22,200 --> 00:30:26,360 ad they'll take you down or if you know even on YouTube certain 607 00:30:26,360 --> 00:30:29,360 things and so they can't but they can't really stop podcasts 608 00:30:29,360 --> 00:30:31,920 and and certain things on Instagram and and influencers 609 00:30:31,920 --> 00:30:34,320 talking about it and getting it done because that's that's the 610 00:30:34,320 --> 00:30:36,440 only way you can really grow because if you if you run Google 611 00:30:36,440 --> 00:30:38,280 ads on stem cells they'll block you. 612 00:30:39,120 --> 00:30:42,720 So it's it is an interesting time in that way. 613 00:30:42,720 --> 00:30:47,120 But I I think because of the ever growing the stain in 614 00:30:47,120 --> 00:30:50,400 mainstream medicine as well. COVID actually helped ironically 615 00:30:50,400 --> 00:30:53,800 enough. Because people just after that, 616 00:30:53,800 --> 00:30:57,160 there's so much distrust in the mainstream narrative and people 617 00:30:57,160 --> 00:30:59,800 are starting to question things more and don't necessarily 618 00:30:59,800 --> 00:31:01,480 always believe what their doctor has to say. 619 00:31:02,080 --> 00:31:03,920 And I think that's and that's the whole point. 620 00:31:03,920 --> 00:31:05,920 I'm not saying believe everything I say either. 621 00:31:05,920 --> 00:31:07,680 You got to fat. It's good to get different 622 00:31:07,680 --> 00:31:11,920 opinions and then just weigh all your options and know what's out 623 00:31:11,920 --> 00:31:13,960 there so you can at least make an informed decision. 624 00:31:14,200 --> 00:31:17,840 The problem is when you go to your average doctor and let's 625 00:31:17,840 --> 00:31:20,000 say you haven't, you have chronic pain or you have an 626 00:31:20,000 --> 00:31:22,680 injury or whatever disease you have, they're only going to give 627 00:31:22,680 --> 00:31:24,520 you what they know. They don't know what they know. 628 00:31:24,760 --> 00:31:26,080 They don't know what they don't know, right. 629 00:31:26,320 --> 00:31:29,200 And and and that's that's the biggest problem is the lack of 630 00:31:29,200 --> 00:31:33,160 education and medical doctors education after medical school 631 00:31:33,160 --> 00:31:36,760 and residency is pretty abysmal. Our our medical school education 632 00:31:36,760 --> 00:31:40,200 is actually terrible as well in in in hindsight because it gives 633 00:31:40,200 --> 00:31:42,960 us a great foundation just for Physiology and pathophysiology 634 00:31:42,960 --> 00:31:46,120 but doesn't really it doesn't it there was very little training 635 00:31:46,120 --> 00:31:49,800 on actual root cause mechanisms and how they play into disease 636 00:31:49,800 --> 00:31:51,800 and targeting those essentially what's called functional 637 00:31:51,800 --> 00:31:54,840 medicine and that's something I had to study on my own and but 638 00:31:54,840 --> 00:31:57,400 there's like little to no teaching on that and which is 639 00:31:57,480 --> 00:32:00,360 like a shame. When you when you reach out to 640 00:32:00,400 --> 00:32:03,360 like doctors and physicians boots on the ground, you know 641 00:32:03,360 --> 00:32:06,400 care caregivers are are they pretty receptive to what you're 642 00:32:06,400 --> 00:32:07,800 having to say? Are you still getting pushback 643 00:32:07,800 --> 00:32:10,280 from them? I'd say it's mixed. 644 00:32:10,280 --> 00:32:14,480 There's definitely some who are receptive and then I would say 645 00:32:14,480 --> 00:32:17,680 the majority are still pretty conservative and there are still 646 00:32:17,680 --> 00:32:21,240 just kind of like, oh, the guidelines don't say this, 647 00:32:21,240 --> 00:32:24,400 therefore it can't be true. Yeah, there's and the guy, where 648 00:32:24,400 --> 00:32:25,480 did the guidelines come from, though? 649 00:32:25,480 --> 00:32:28,360 The guidelines come from specialists who are considered 650 00:32:28,360 --> 00:32:31,680 top in their field and who all have industry ties. 651 00:32:32,120 --> 00:32:35,120 So it's it's just a system that feeds itself. 652 00:32:35,920 --> 00:32:38,000 How how long has Y'all's company been running? 653 00:32:38,040 --> 00:32:43,600 When did you start it? My own company has been around 654 00:32:43,600 --> 00:32:46,200 only for a year actually. It's been crazy where we went 655 00:32:46,200 --> 00:32:48,880 from start up to scale up. We're growing like really fast. 656 00:32:49,560 --> 00:32:52,200 And then the the mini circle gene therapy company's been 657 00:32:52,200 --> 00:32:56,280 around this. We started, I think, in 2017, so 658 00:32:56,280 --> 00:32:58,720 almost seven years. And what, what made you want to 659 00:32:58,720 --> 00:33:01,080 go down this trajectory, man? Like what were you doing prior 660 00:33:01,080 --> 00:33:04,240 to and then had had you switched course to this? 661 00:33:04,240 --> 00:33:05,760 Like what was the the catalyst there? 662 00:33:06,680 --> 00:33:09,800 Yeah, I'm I'm a I'm a gym, gym junkie at heart. 663 00:33:09,800 --> 00:33:12,200 So I'm a meathead funny, you know. 664 00:33:12,720 --> 00:33:17,200 So I was a personal trainer and I'm sure, you know, if being in 665 00:33:17,200 --> 00:33:19,600 the fitness world, you have a very different perspective about 666 00:33:19,600 --> 00:33:21,880 health because you you'd literally see in front of you 667 00:33:22,160 --> 00:33:25,480 how fitness, just fitness, exercise, nutrition can fix so 668 00:33:25,480 --> 00:33:27,720 many chronic diseases and and help so many people. 669 00:33:28,200 --> 00:33:31,120 So I always had that lens when I was in medical schools. 670 00:33:31,120 --> 00:33:34,440 Kind of like why are we learning more about prevention and why 671 00:33:34,440 --> 00:33:37,560 aren't we learning more about how to actually treat the root 672 00:33:37,560 --> 00:33:40,120 cause? So I was just, that was just my 673 00:33:40,120 --> 00:33:42,760 bias, I guess coming from the personal training world, which 674 00:33:42,760 --> 00:33:46,560 obviously paid off because it's LED me down this road of kind of 675 00:33:46,560 --> 00:33:50,520 innovating and discovering new things and being able to look at 676 00:33:50,520 --> 00:33:52,280 things differently from the average doctor. 677 00:33:53,120 --> 00:33:55,080 Yeah. No, that's I think that's a good 678 00:33:55,280 --> 00:33:57,440 background to have, man. Like you, you didn't get into it 679 00:33:57,440 --> 00:33:59,720 because of any financial means. Like you just simply recognize 680 00:33:59,720 --> 00:34:02,320 the benefit of how you could subject your body to certain 681 00:34:02,320 --> 00:34:04,440 stimulus, IE the training, and then benefit from it. 682 00:34:04,440 --> 00:34:08,840 So that's the purest lens to look at Medic Medical, you know, 683 00:34:08,840 --> 00:34:12,000 intervention and health through. Yeah. 684 00:34:12,000 --> 00:34:15,239 No exactly. I Jordan Peterson on his podcast 685 00:34:15,280 --> 00:34:17,560 he's like why should people trust you And I'm like that's 686 00:34:17,560 --> 00:34:20,719 basically it. It's like because I I don't have 687 00:34:20,719 --> 00:34:24,639 I was never motivated by finance and and then Canada especially 688 00:34:24,639 --> 00:34:27,440 where we're not we don't even we're not really really talk 689 00:34:27,440 --> 00:34:29,920 about that because it's it's a publicly funded system. 690 00:34:29,920 --> 00:34:33,719 So you never really look at how much doctors make. 691 00:34:33,760 --> 00:34:36,840 Well, at least I didn't. And and I think that when you 692 00:34:36,840 --> 00:34:38,600 look at it from that and you're kind of just looking at it from 693 00:34:38,600 --> 00:34:41,520 like how do I help more people, it naturally takes you down this 694 00:34:41,520 --> 00:34:44,280 route. Because I mean, I just can't see 695 00:34:44,280 --> 00:34:46,440 as an average physician, if you're in the regular system, 696 00:34:46,440 --> 00:34:48,920 you obviously see it's broken unless you're like a trauma 697 00:34:48,920 --> 00:34:51,280 surgeon or those are different things. 698 00:34:51,679 --> 00:34:54,480 But if you're dealing with chronic disease care like 699 00:34:54,480 --> 00:34:57,080 internal medicine, family medicine and a lot of these 700 00:34:57,080 --> 00:34:59,000 specialists who are just prescribing medications for 701 00:34:59,000 --> 00:35:01,320 chronic illnesses, how can you not see it's broken? 702 00:35:01,400 --> 00:35:04,960 It's so obvious and and I think most of them are and they know. 703 00:35:04,960 --> 00:35:06,760 I think a lot of them know actually and a lot of my 704 00:35:06,760 --> 00:35:09,640 physician and friends know that it's just most of them are too 705 00:35:09,640 --> 00:35:14,280 burnt out or tired to care. And the ones who want to make a 706 00:35:14,280 --> 00:35:16,120 difference, they're just, they just don't know how. 707 00:35:16,120 --> 00:35:19,720 And so I'm hoping that we can kind of be almost like a beacon 708 00:35:19,720 --> 00:35:23,120 of hope or light that we can create a lot of systemic change. 709 00:35:23,520 --> 00:35:26,080 Totally, ma'am. Out of out of curiosity, what is 710 00:35:26,080 --> 00:35:28,360 the the publicly funded system in Canada like? 711 00:35:28,440 --> 00:35:30,720 All in all, like, do you think that is a significantly better 712 00:35:30,720 --> 00:35:32,160 system than what we have here in the States? 713 00:35:33,120 --> 00:35:35,960 No, it's probably way worse. Probably way worse. 714 00:35:37,320 --> 00:35:41,120 It's I mean from a metrics perspective it's it's probably 715 00:35:41,280 --> 00:35:44,120 it is OK from from if you look at the numbers in terms of GDP 716 00:35:44,120 --> 00:35:48,120 per capita and how much you spend you guys are worse but but 717 00:35:48,520 --> 00:35:53,200 we also have people dying while waiting in emergency rooms and 718 00:35:53,200 --> 00:35:56,080 we have people waiting six months to get Mris when they 719 00:35:56,080 --> 00:35:58,760 have cancer. So and there's tragic cases like 720 00:35:58,760 --> 00:36:01,880 where people die in those cases like it's so we have pretty some 721 00:36:01,880 --> 00:36:05,320 pretty horrific things that I don't think should happen in the 722 00:36:05,320 --> 00:36:08,680 developed country whereas at least in the US if at least you 723 00:36:08,680 --> 00:36:13,320 can pay to get those things done and but that but then it's too 724 00:36:13,320 --> 00:36:15,960 much to the other extreme where it's like people are paying way 725 00:36:15,960 --> 00:36:18,400 too much and insurers are charging so much and it's like 726 00:36:18,400 --> 00:36:20,320 at the end of the day who's who's making all the money? 727 00:36:20,320 --> 00:36:23,200 It's not the doctors. Doctors do pay it's it's 728 00:36:23,200 --> 00:36:26,000 insurers and it's the pharmaceutical companies and 729 00:36:26,000 --> 00:36:28,600 it's the hospitals. So it's just this business 730 00:36:28,600 --> 00:36:30,440 that's feeding itself. What would be? 731 00:36:30,440 --> 00:36:32,880 I mean this is just us totally blue sky thinking that, but what 732 00:36:32,880 --> 00:36:35,680 would be the ideal set up situation? 733 00:36:35,680 --> 00:36:38,480 Like would it be through a governmental entity at all or 734 00:36:38,480 --> 00:36:40,680 would it just be quality? Quality. 735 00:36:40,680 --> 00:36:45,360 Well I think first we have to we have to maximize medicine 3.0 736 00:36:45,800 --> 00:36:49,320 and which means prevention and it's like how do we scale that 737 00:36:49,320 --> 00:36:54,280 and we do have a company called Exalt XAL T dot Fit and we're 738 00:36:54,280 --> 00:36:56,320 basically our goal is to do that. 739 00:36:56,320 --> 00:36:59,360 I mean it's super ambitious but we're we're trying to basically 740 00:36:59,360 --> 00:37:02,880 use virtual trainers like personal trainers and fitness 741 00:37:02,880 --> 00:37:05,560 coaches because we and just making it more accessible by 742 00:37:05,560 --> 00:37:08,440 using machine learning and having a dashboard that allows 743 00:37:08,440 --> 00:37:11,040 every tracking. Because as I'm sure you know the 744 00:37:11,040 --> 00:37:13,760 biggest issue is behavior change and it's we we're trying to 745 00:37:13,760 --> 00:37:15,920 solve for behavior change by just having you accountable to 746 00:37:15,920 --> 00:37:18,080 someone. I don't think AI on its own can 747 00:37:18,080 --> 00:37:20,440 replace it. I think people need a coach and 748 00:37:20,440 --> 00:37:22,200 they need someone to keep them accountable and that's the only 749 00:37:22,200 --> 00:37:23,480 way they're going to stick to it long term. 750 00:37:24,240 --> 00:37:27,360 And then once you've solved for behavior change and you scale up 751 00:37:27,360 --> 00:37:29,520 medicine 3 point O where it's like OK, this is super 752 00:37:29,520 --> 00:37:31,600 accessible and you're you're actually getting these 753 00:37:31,600 --> 00:37:35,440 preventative care methods, then they're like 80% of chronic 754 00:37:35,440 --> 00:37:38,760 disease goes away And then that's based off long term data. 755 00:37:38,760 --> 00:37:41,640 We know that 80% of chronic illnesses are linked to 756 00:37:41,880 --> 00:37:46,240 lifestyle and then you can add in the layer have hopefully one 757 00:37:46,240 --> 00:37:49,160 day where these imagine where intravenous stem cells or 758 00:37:49,160 --> 00:37:51,360 exosomes and these gene therapies are covered by 759 00:37:51,360 --> 00:37:53,320 insurance and you can go to your doctor every two years and get 760 00:37:53,320 --> 00:37:56,480 them done and give you vitality and energy and how to prevent 761 00:37:56,480 --> 00:37:59,720 disease and that would be and then and then instead of just 762 00:37:59,720 --> 00:38:02,120 chasing disease you're you're preventing disease altogether 763 00:38:02,120 --> 00:38:04,160 but that's not good for business. 764 00:38:04,160 --> 00:38:07,480 So I don't, I don't know if that will happen, but I hope that 765 00:38:07,480 --> 00:38:08,640 will happen. Yeah. 766 00:38:09,080 --> 00:38:11,040 Well, that that our hopes are aligned there for sure. 767 00:38:11,360 --> 00:38:14,040 If you were to map out like a a timeline, chronologically 768 00:38:14,040 --> 00:38:16,440 Speaking, of what this would look like as far as the 769 00:38:16,440 --> 00:38:18,440 technology goes, the gene cell therapy, like what? 770 00:38:18,440 --> 00:38:22,280 What do you forecast over the next 10, twenty, 3050 years? 771 00:38:23,880 --> 00:38:27,560 Yeah, I think, I think over the next in 10 years we'll see stem 772 00:38:27,560 --> 00:38:30,600 cells become mainstream, which means they'll be accessible. 773 00:38:30,600 --> 00:38:34,200 They'll probably be available everywhere and including in 774 00:38:34,200 --> 00:38:37,840 North America I think as well because FDA and healthcare, I 775 00:38:37,840 --> 00:38:42,040 mean they they have no no choice but to admit that these things 776 00:38:42,040 --> 00:38:44,560 work and different cell therapies for different 777 00:38:44,560 --> 00:38:47,560 conditions and it'll probably it'll be regulated but at least 778 00:38:47,560 --> 00:38:50,360 it'll be permitted. And then same thing with the 779 00:38:50,360 --> 00:38:53,080 gene therapies. I see that stuff really becoming 780 00:38:53,560 --> 00:39:00,800 mainstream and it might be sooner, but I think often the 781 00:39:00,800 --> 00:39:04,960 kind of precipitous or kind of trigger to for a lot of these 782 00:39:04,960 --> 00:39:09,240 things to become mainstream, as sad as it is, it's kind of like 783 00:39:09,240 --> 00:39:14,040 cosmetics or the sex industry. And the reason I use that 784 00:39:14,040 --> 00:39:17,600 example is like platelet rich plasma like PRP was around for a 785 00:39:17,600 --> 00:39:21,440 long time like you know almost 2030 years for for 786 00:39:21,480 --> 00:39:24,720 musculoskeletal conditions. But it didn't become mainstream 787 00:39:24,720 --> 00:39:29,520 until until they started using it for hair and then face the 788 00:39:29,520 --> 00:39:33,240 vampire facial and then the pee shot like penis and then people 789 00:39:33,240 --> 00:39:36,960 started talking about it. So it's I feel like once we're 790 00:39:36,960 --> 00:39:39,320 all working on the gene therapy product for cosmetics called 791 00:39:39,320 --> 00:39:42,320 copper peptide gene therapy. So I feel like that and then 792 00:39:42,320 --> 00:39:44,240 we're also working on women's Viagra gene therapy. 793 00:39:44,240 --> 00:39:46,440 So I feel like once we've launched those products, I think 794 00:39:46,440 --> 00:39:49,080 gene therapy will become a lot more popular and more 795 00:39:49,080 --> 00:39:52,160 mainstream. And that'll be a good hopefully 796 00:39:52,160 --> 00:39:57,760 trigger for more and more people to want to, yeah, to want to do 797 00:39:57,760 --> 00:40:01,680 it. And and then that'll also pave 798 00:40:01,680 --> 00:40:04,000 the way for us to do more research in clinical trials and 799 00:40:04,000 --> 00:40:06,680 then show that, hey, this stuff actually works and have insurers 800 00:40:06,680 --> 00:40:09,640 cover it. And then in in 20 years and 30 801 00:40:09,640 --> 00:40:12,640 years, what I see is customized cell therapies and gene 802 00:40:12,640 --> 00:40:15,040 therapies, which means we can take, we can take a cell from 803 00:40:15,040 --> 00:40:18,760 your body, a defective cell and correct the defect and then 804 00:40:18,760 --> 00:40:21,040 manufacture the healthy cell and then put it back in your body 805 00:40:21,040 --> 00:40:22,920 and fix whatever problem you had in the first place. 806 00:40:23,680 --> 00:40:27,640 So customize to your body. That's that's gonna happen for 807 00:40:27,640 --> 00:40:31,160 sure in our in our lifetime. Yeah, it's a lot of people are 808 00:40:31,160 --> 00:40:36,000 talking about doing that like in embryonic stages, like for, you 809 00:40:36,000 --> 00:40:39,400 know, people before they're born yet, which is kind of crazy that 810 00:40:39,400 --> 00:40:42,000 that is even a possibility when people are kind of like playing 811 00:40:42,000 --> 00:40:45,440 God with that one. Well, that already happened in 812 00:40:45,440 --> 00:40:47,040 China and then the guy got arrested. 813 00:40:47,280 --> 00:40:49,760 But I feel like they just did that for optics because I'm 814 00:40:49,760 --> 00:40:52,960 pretty sure China and Russia are probably doing that. 815 00:40:53,200 --> 00:40:57,400 I just based off their ethics, the way they are with things and 816 00:40:57,400 --> 00:40:59,240 they want to obviously be the first to do things. 817 00:40:59,240 --> 00:41:03,200 And yeah, but the gene editing embryos is a whole Pandora's box 818 00:41:03,280 --> 00:41:05,920 And I think there's going to have to be a lot of regulation 819 00:41:05,920 --> 00:41:08,760 created around that and ethicists and a lot of people to 820 00:41:08,760 --> 00:41:11,480 figure out what's the best way to regulate that because 821 00:41:11,480 --> 00:41:14,360 obviously gene editing embryos can be life saving potentially 822 00:41:14,360 --> 00:41:18,200 for some embryo have genetic deficits, right. 823 00:41:18,880 --> 00:41:22,160 So but on the other side of it then you can start manipulating 824 00:41:22,160 --> 00:41:26,320 and start being like oh we want to enhance their height or why 825 00:41:26,320 --> 00:41:28,840 don't we make them have this eye color and this type of stuff. 826 00:41:28,840 --> 00:41:32,480 So then it just, yeah it just gets into a whole controversial 827 00:41:32,720 --> 00:41:37,280 box that I hope smarter people than what's been done with the 828 00:41:37,280 --> 00:41:40,600 tech industry will create. Because the tech if anything 829 00:41:40,600 --> 00:41:43,320 I've we've learned from big tech is lack of regulation is not a 830 00:41:43,320 --> 00:41:46,680 good idea because then like obviously I'm I don't know if 831 00:41:46,680 --> 00:41:49,320 you've heard about how you know technology probably shouldn't be 832 00:41:49,600 --> 00:41:53,280 so overly used for young kiddos with on screens and stuff but 833 00:41:53,320 --> 00:41:55,080 it's just like no regulation around it. 834 00:41:55,080 --> 00:41:58,480 So it's just like, you know, it's like dopamine casino for 835 00:41:58,480 --> 00:42:00,120 kids. Yeah, no, totally. 836 00:42:00,120 --> 00:42:02,440 It's it's scary times for sure as far as that's concerned. 837 00:42:02,640 --> 00:42:04,120 But I would hope there wouldn't be. 838 00:42:04,200 --> 00:42:06,880 There is, but I hope that that that the controversy wouldn't be 839 00:42:06,880 --> 00:42:10,880 nearly as heightened for, you know, simple acute inflammation 840 00:42:10,880 --> 00:42:15,040 injuries, ailments that could and should be corrected, you 841 00:42:15,040 --> 00:42:17,440 know, relatively easily with this technology as we know it 842 00:42:17,440 --> 00:42:19,040 now. It's unfortunate that people 843 00:42:19,040 --> 00:42:20,920 have to go to a third world country or not third world 844 00:42:20,920 --> 00:42:23,840 country but a different country to get this care. 845 00:42:24,000 --> 00:42:26,640 It's like for people listening now that are in the States, for 846 00:42:26,640 --> 00:42:28,600 instance, like what is their best option? 847 00:42:28,600 --> 00:42:31,760 Like if they're wanting to, you know, mediate some type of. 848 00:42:32,040 --> 00:42:35,800 Well, the problem is if you Google stem cells US, you'll 849 00:42:35,800 --> 00:42:39,760 find hundreds of clinics, many of them being in Florida and 850 00:42:39,760 --> 00:42:43,200 that the problem is that they're not legitimate clinics because 851 00:42:43,840 --> 00:42:48,000 stem cells are illegal and not FDA approved, both stem cells 852 00:42:48,000 --> 00:42:50,160 and exosomes. So it's like how are all these 853 00:42:50,160 --> 00:42:53,280 clinics operating? It's just FDA can't keep up and 854 00:42:53,280 --> 00:42:57,800 shutting them all down, which it's not a you know, it's it's 855 00:42:57,800 --> 00:43:00,400 not a great environment. Because the problem is when you 856 00:43:00,400 --> 00:43:02,840 don't, when you don't have proper regulatory oversight, 857 00:43:03,120 --> 00:43:05,080 then you have people. Then you have bad players who 858 00:43:05,080 --> 00:43:07,280 don't really know what and they're just trying to cash in 859 00:43:08,000 --> 00:43:10,080 on the opportunity because they know there's some desperate 860 00:43:10,080 --> 00:43:12,320 people out there who are just Googling stem cells and will go 861 00:43:12,320 --> 00:43:13,800 to the first person who's nearby. 862 00:43:14,200 --> 00:43:16,920 And the problem in the US is you're only allowed to use 863 00:43:16,920 --> 00:43:20,080 autologous stem cells, which means from your own body and 864 00:43:20,080 --> 00:43:22,080 your own body. Stem cells after age 40 are 865 00:43:22,240 --> 00:43:24,360 really not that useful because there's something called stem 866 00:43:24,360 --> 00:43:27,080 cell exhaustion, which is one of the hallmarks of aging, which 867 00:43:27,080 --> 00:43:30,120 basically denotes the stem cells functioning to repair and 868 00:43:30,120 --> 00:43:32,240 regenerate tissue decreases as you age. 869 00:43:32,840 --> 00:43:36,000 Plus, you're not allowed to expand stem cells, which is the 870 00:43:36,000 --> 00:43:38,240 dosing. So if I take stem cells from 871 00:43:38,240 --> 00:43:41,080 your body, from your fat or your or your bone marrow, and I 872 00:43:41,080 --> 00:43:43,920 inject it back in, I may be injecting 500,000 or something 873 00:43:43,920 --> 00:43:46,880 to maybe a million at most. And that can still be helpful 874 00:43:46,880 --> 00:43:48,560 for certain conditions. I'm not saying it doesn't work, 875 00:43:48,560 --> 00:43:51,200 but it's often temporary. And for muscle tendon tears, it 876 00:43:51,200 --> 00:43:54,400 can still work for those issues. But if you're talking about like 877 00:43:54,400 --> 00:43:58,960 really severe osteoarthritis or chronic illnesses, it's not 878 00:43:58,960 --> 00:44:01,560 gonna really do much for long term results. 879 00:44:01,560 --> 00:44:04,520 And so then you have to go into work called culture expanded 880 00:44:04,520 --> 00:44:07,200 where you actually grow the stem cells for a couple weeks and 881 00:44:07,200 --> 00:44:10,040 then we we you know we put like 100 million or 200 million or 882 00:44:10,040 --> 00:44:12,680 sometimes even more. And so obviously if you have 100 883 00:44:12,680 --> 00:44:15,320 times higher dosing, just intuitively you're probably 884 00:44:15,320 --> 00:44:16,480 going to think it's going to work better. 885 00:44:16,480 --> 00:44:19,120 And it's it's not that more is always better, but there in this 886 00:44:19,120 --> 00:44:22,320 case it actually is there is a certain dose that you have to 887 00:44:22,320 --> 00:44:24,920 have for these things to be efficacious, which is the 888 00:44:24,920 --> 00:44:27,960 biggest problem I see with the clinics that, you know Joe 889 00:44:27,960 --> 00:44:30,920 recommends and some of the other clinics is is dosing. 890 00:44:30,920 --> 00:44:33,680 And I've had many patients go to those places and not get good 891 00:44:34,000 --> 00:44:36,680 treatments. And even like, you know, like 892 00:44:36,680 --> 00:44:41,720 Israel, we had a post with him Adiosania, he's AUFC fighter and 893 00:44:42,280 --> 00:44:43,680 you know he was going to go to CPI. 894 00:44:43,680 --> 00:44:46,520 But the problem is luckily he came to me just because they're, 895 00:44:46,920 --> 00:44:49,840 it has to be the, the interventional skill set and how 896 00:44:49,840 --> 00:44:52,360 you go to stem cells. There's so much nuance to it, 897 00:44:52,360 --> 00:44:55,640 and I'm not saying that we're the best, but I just, I've 898 00:44:55,640 --> 00:44:57,280 learned from different people around the world who are the 899 00:44:57,280 --> 00:44:58,800 best. I think like in Japan and in 900 00:44:58,800 --> 00:45:01,200 other in Europe and stuff we've been doing for such a long time. 901 00:45:01,200 --> 00:45:03,560 And I'm just kind of taking their practices and bringing 902 00:45:03,560 --> 00:45:04,960 them here. Gotcha. 903 00:45:05,560 --> 00:45:08,200 So I'm, I'm 32 that's kind of selfish question here but I'm 904 00:45:08,200 --> 00:45:10,040 not over the the hill yet so to speak. 905 00:45:10,320 --> 00:45:13,160 Is there anything that I could and should be doing to kind of 906 00:45:13,160 --> 00:45:15,560 play for the long game like STEM? 907 00:45:15,560 --> 00:45:17,600 Cell. Yeah, I mean, like, to me it's 908 00:45:17,600 --> 00:45:19,400 just, it's all about the means, right? 909 00:45:19,400 --> 00:45:23,040 Like if you have the means to do it, there's no reason you can't 910 00:45:23,040 --> 00:45:26,800 do the stuff starting in your 30s or even in your 20s because 911 00:45:27,200 --> 00:45:31,880 it has so much upside with pretty much like little to no 912 00:45:31,880 --> 00:45:34,640 downside. So the I think the biggest 913 00:45:34,640 --> 00:45:37,080 things people in your age group like to do probably is the fall 914 00:45:37,080 --> 00:45:39,600 of Saturn just because especially if you're a lifter, 915 00:45:39,600 --> 00:45:42,560 it just gives you a better, it gives you better pumps because 916 00:45:42,560 --> 00:45:45,920 it increases neurological Dr. which is pretty cool and then it 917 00:45:45,920 --> 00:45:50,160 just gives you better recovery, better strength and yeah and 918 00:45:50,160 --> 00:45:53,440 then some people what we do for them too is the, the IV, the 919 00:45:53,440 --> 00:45:56,840 intravenous stem cells as part of our anti aging stuff and that 920 00:45:56,840 --> 00:45:59,560 just helps with recovery, it can improve HRV and sleep. 921 00:45:59,560 --> 00:46:01,520 So. So there's some, there is some 922 00:46:01,840 --> 00:46:03,800 tangible benefits you can see from that stuff. 923 00:46:03,800 --> 00:46:06,360 But I think, I think for you probably if you're going to just 924 00:46:06,360 --> 00:46:08,760 do one thing, probably the false data would probably be the thing 925 00:46:08,760 --> 00:46:10,920 that you would be like, oh, this was this is awesome. 926 00:46:11,560 --> 00:46:14,800 Would it be worthwhile to do any stem cell banking like so I can 927 00:46:14,800 --> 00:46:17,560 kind of sit on it until a lot of this regulatory stuff gets 928 00:46:17,560 --> 00:46:19,920 worked out? You don't need to because we're 929 00:46:19,920 --> 00:46:22,600 getting into the era of genetically engineering stem 930 00:46:22,600 --> 00:46:27,320 cells so we can manufacture them and make better ones from 931 00:46:27,320 --> 00:46:28,960 someone else than your own body anyway. 932 00:46:28,960 --> 00:46:31,800 Even even the umbilical cord, I think it's going to be 933 00:46:31,840 --> 00:46:33,560 relatively outdated within the next few years. 934 00:46:33,560 --> 00:46:36,600 I mean it's always starting to be because like the Parkinson's 935 00:46:36,600 --> 00:46:38,960 trial is talking about that was with the second generation stem 936 00:46:38,960 --> 00:46:41,400 cells as well. So we're going to be 937 00:46:41,400 --> 00:46:45,760 transitioning to those later this year and the idea is we'll 938 00:46:45,760 --> 00:46:47,680 use, we'll still have umbilical cords available and there's 939 00:46:47,680 --> 00:46:50,200 still efficacious for certain things, but the second Gen. has 940 00:46:50,200 --> 00:46:52,840 more definitely more potential. That's crazy, man. 941 00:46:52,840 --> 00:46:54,720 It's crazy what science is allowing us to do now. 942 00:46:55,080 --> 00:46:57,160 It's amazing. Yeah, I mean it's it's it, it 943 00:46:57,160 --> 00:47:00,480 sounds like sci-fi right, where you're engineering cells to do 944 00:47:00,480 --> 00:47:03,160 what you want. So it's it's called synthetic 945 00:47:03,160 --> 00:47:06,520 biology which is really exciting field and it's only gonna get 946 00:47:06,880 --> 00:47:10,760 more and more sophisticated. I'm excited to see where it goes 947 00:47:10,760 --> 00:47:12,720 for sure. I know you got to catch a flight 948 00:47:12,720 --> 00:47:14,560 here soon, so I don't want to keep you long, but for the 949 00:47:14,560 --> 00:47:17,800 listeners sake and for your sake and what you're trying to get 950 00:47:17,800 --> 00:47:19,720 the word out there for, what can people do? 951 00:47:19,720 --> 00:47:23,400 Where can they go to learn more? What should people do to? 952 00:47:23,400 --> 00:47:25,240 Learn more. I think at the very least like 953 00:47:25,640 --> 00:47:28,920 I'm a huge fan of peptides and I think really learning about 954 00:47:28,920 --> 00:47:31,840 peptides and educating yourself because they can really make a 955 00:47:31,840 --> 00:47:34,760 difference. Like NMN is is not a peptide but 956 00:47:34,760 --> 00:47:37,960 it is a molecule that's been talked about a lot for anti 957 00:47:37,960 --> 00:47:40,240 aging. And I think that and there's 958 00:47:40,240 --> 00:47:44,920 certain peptides like s s 31 and I see JC Apramellian which I 959 00:47:44,920 --> 00:47:46,520 think are great to cycle throughout the year. 960 00:47:46,520 --> 00:47:48,560 So I think those are and they're not expensive and those things 961 00:47:48,560 --> 00:47:51,080 are easy things I think everyone can do that can add into their 962 00:47:51,080 --> 00:47:54,960 longevity routine. And then as this stuff hopefully 963 00:47:54,960 --> 00:47:57,240 becomes more and more accessible then it's obviously this is like 964 00:47:57,240 --> 00:48:00,320 the next step up. But I feel like a lot of people 965 00:48:00,320 --> 00:48:03,840 who you know listen to your show I'm sure or a health conscious 966 00:48:03,840 --> 00:48:05,360 and they have the foundations in place. 967 00:48:05,360 --> 00:48:07,640 So it's like what else is out there and I would say it goes 968 00:48:07,640 --> 00:48:10,000 peptides and then cell and gene therapy after that. 969 00:48:10,440 --> 00:48:11,160 Got you. Yeah. 970 00:48:11,160 --> 00:48:13,480 I just finished a book from Saint Clair and he was, you 971 00:48:13,480 --> 00:48:16,560 know, very bullish on Intamin. Do you do that yourself? 972 00:48:16,560 --> 00:48:17,640 Like how do you kind of work that into? 973 00:48:17,640 --> 00:48:18,080 Your routine? Yeah. 974 00:48:18,080 --> 00:48:18,960 No. Yeah, I started. 975 00:48:19,000 --> 00:48:22,760 I started doing it myself and I I think it's so the reason 976 00:48:22,760 --> 00:48:26,040 people to understand why this molecule in particular is so 977 00:48:26,040 --> 00:48:30,760 powerful and it's so beneficial is because the mitochondria, I'm 978 00:48:30,760 --> 00:48:33,200 sure everyone from high school, high school biology remembers 979 00:48:33,240 --> 00:48:35,720 mitochondria are the powerhouses of the cell. 980 00:48:35,760 --> 00:48:39,280 There's these little organelles that are, quote UN quote 981 00:48:39,280 --> 00:48:41,640 powerhouses, but there's so much more than that we're realizing 982 00:48:41,640 --> 00:48:45,000 they're they they help with signal transduction, iron and 983 00:48:45,000 --> 00:48:48,600 calcium homeostasis. And most importantly, they they 984 00:48:48,600 --> 00:48:51,320 are probably mostly involved in cellular senescence. 985 00:48:51,320 --> 00:48:54,960 Which means if the mitochondria become dysfunctional and there's 986 00:48:54,960 --> 00:48:58,920 too much oxidative stress, and that can be a signal for the 987 00:48:58,920 --> 00:49:01,160 cells over time to become senescent. 988 00:49:01,280 --> 00:49:03,360 And there's also something called mitophagy, which is 989 00:49:03,760 --> 00:49:07,440 mitochondria themselves are supposed to send a signal to 990 00:49:07,480 --> 00:49:10,560 become catabolic and kind of disappear, but sometimes they 991 00:49:10,560 --> 00:49:12,120 don't and they become senescent too. 992 00:49:12,440 --> 00:49:14,920 So and then when you have build up of senescent cells, that's 993 00:49:14,960 --> 00:49:17,480 least of chronic inflammation and all these other things. 994 00:49:17,480 --> 00:49:20,280 So that's really one of the biggest. 995 00:49:20,600 --> 00:49:23,960 What's called theories of aging is based off mitochondria 996 00:49:23,960 --> 00:49:25,720 dysfunction. And to really put that in 997 00:49:25,720 --> 00:49:28,880 perspective, when you're five years old, they've done studies 998 00:49:28,880 --> 00:49:32,520 where if you take a 5 year old, they have 0% dysfunctional 999 00:49:32,520 --> 00:49:35,160 mitochondria. If you take a 75 year old, they 1000 00:49:35,160 --> 00:49:38,480 have 95% mitochondrial dysfunction. 1001 00:49:38,760 --> 00:49:42,680 So what does mitochondrial dysfunction really stem from? 1002 00:49:43,000 --> 00:49:45,840 It stems from the different intermediaries. 1003 00:49:45,840 --> 00:49:48,840 And the things that make up mitochondrial function such as 1004 00:49:48,840 --> 00:49:53,480 NMN helps to support NAD, which is A, which is a molecule that 1005 00:49:53,680 --> 00:49:55,640 helps to produce AATP, which is energy. 1006 00:49:55,640 --> 00:50:00,600 So basically NMN SS31, which is another peptide I both support 1007 00:50:00,800 --> 00:50:03,480 mitochondrial function, and there's been studies in animals 1008 00:50:03,680 --> 00:50:08,600 showing NMN and S S 31 together are more efficacious, so I 1009 00:50:08,600 --> 00:50:10,520 usually recommend taking them together because they have 1010 00:50:10,520 --> 00:50:12,600 different mechanisms as well. Gotcha. 1011 00:50:12,880 --> 00:50:14,040 Very cool. Very cool. 1012 00:50:14,440 --> 00:50:16,400 What do people go to Find out more about you, man, and to dive 1013 00:50:16,400 --> 00:50:18,880 deeper into your ecosystem? Yeah. 1014 00:50:18,880 --> 00:50:22,960 I mean I I'm pretty active on Instagram at ER dot Akon Khan 1015 00:50:22,960 --> 00:50:25,240 and I think TikTok is the Regen doc. 1016 00:50:25,640 --> 00:50:27,840 I think that one is just for fun. 1017 00:50:27,840 --> 00:50:30,880 But we we post stuff on there as well just because especially 1018 00:50:30,880 --> 00:50:33,480 with the younger generation I mean we get it's funny I had a 1019 00:50:33,880 --> 00:50:36,440 I've I've had so many people in their even in their 60s I'm like 1020 00:50:36,440 --> 00:50:38,040 how'd you find me? They're like TikTok I was like 1021 00:50:38,040 --> 00:50:40,920 what That's crazy. And so it's yeah. 1022 00:50:40,920 --> 00:50:45,160 So we're very active on there and our website's eternal, like 1023 00:50:45,160 --> 00:50:48,840 eternal without AL dot health, and you can just go on there and 1024 00:50:48,840 --> 00:50:50,120 book an appointment and if you have. 1025 00:50:50,120 --> 00:50:51,600 And there's lots of information too. 1026 00:50:51,600 --> 00:50:54,240 And a lot of times people aren't sure if this stuff can help them 1027 00:50:54,240 --> 00:50:55,800 or not. And if you're struggling out 1028 00:50:55,800 --> 00:50:57,800 there and you're not sure what your options are, you can always 1029 00:50:57,800 --> 00:50:59,520 get a console and see if we can help you. 1030 00:50:59,920 --> 00:51:01,720 Awesome man. Well I certainly appreciate the 1031 00:51:01,720 --> 00:51:04,280 time Doctor Khan, and I appreciate you being on the tip 1032 00:51:04,280 --> 00:51:06,800 of the spear cutting edge and doing this research and doing it 1033 00:51:06,800 --> 00:51:08,400 for the right reasons, changing lives. 1034 00:51:09,000 --> 00:51:11,200 So I'm I'm definitely excited to follow along and see how this 1035 00:51:11,200 --> 00:51:13,760 unfolds as time progresses. So keep fighting the good fight, 1036 00:51:13,760 --> 00:51:15,040 man. Yeah. 1037 00:51:15,040 --> 00:51:15,800 Thanks. Appreciate it. 1038 00:51:16,000 --> 00:51:17,080 Have a good one, Sir. Take care. 1039 00:51:18,000 --> 00:51:18,120 Bye.