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Welcome back, pet parents. 
I hope you and your family and 

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your fur babies had a wonderful 
holiday. 

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I know we're in this weird place
where like time doesn't exist 

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right after the holidays and 
like going into the new year. 

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And I just want to say thank you
so much for being here with us. 

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Being a dedicated pet parent. 
I have a very, very important 

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episode today, and I have been 
planning this for, gosh, a 

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couple of months now just trying
to gather information and get it

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to you. 
And I'm hopeful to have a 

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particular veterinarian back on 
the podcast to talk to you about

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it some more because we can't 
get the word out quick enough or

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far enough. 
And So what we're going to be 

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talking about today is a 
prescription medication for 

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dogs, it's called Librella. 
For cats, it's called Silencia, 

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but it's basically the same 
thing. 

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So what I'm going to do is just 
give you a rundown of everything

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I have learned about this and I 
will and I'll give you some 

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recommendations of where to go 
to learn more about this. 

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Because everything that I have 
learned about it and has been 

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from Doctor Josie Bug, who has 
been on the podcast in the past.

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And hopefully I'll be able to 
have her back on to talk a 

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little bit more in detail about 
specifically about what to do if

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your animal has had this 
injection once or multiple times

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or there's so much unknown 
around it. 

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So really quickly, let me let me
do my little spiel. 

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We'll jump into everything. 
If you're new here, my name is 

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Jessica. 
I am a canine nutritionist, a 

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feline nutritionist, a holistic 
pet health coach, and a positive

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reinforcement dog trainer. 
And of course, I'm also the host

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of this podcast that you're 
listening to right now, the Pet 

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Parenting Reset. 
I'm so happy you're here. 

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I'm so happy you have decided to
be the best pet parent you can 

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be and continue to learn and 
increase our pets health span. 

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That's the goal here really 
quickly. 

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If you do want, I am still doing
one-on-one consultations. 

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My packages are changing in the 
new year. 

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I'll have my existing package up
for a little while just to give 

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people a little bit of time to 
get used to the new packages. 

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But you can find all of that at 
jessicalfisher.com. 

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Also LinkedIn the show notes. 
So let's get into Librella and 

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Silencia. 
So right off the bat, I'll, I'll

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give this to you again at the 
end, but pet pet. 

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So Pet advocare.com is a website
you can go to learn more if you 

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have more questions and I'm sure
you will because this is a very 

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complex topic. 
And again, all of this 

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information I have been learning
over the past few months from 

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Doctor Josie Bug. 
So Librella is what it's called 

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for dogs. 
Silencia is what it is called 

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for cats. 
And it's it's considered by the 

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FDA a biologic and a biologic is
considered the same thing as a 

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vaccine. 
This is a monoclonal antibody. 

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It's the same class as 
Cytopoint. 

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So one of the biggest problems 
here is that the pharmaceutical 

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reps are promising that there 
are absolutely no side effects. 

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So veterinarians who don't have 
the time, energy, whatever to do

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their own research, who trust 
their pharmaceutical reps are 

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believing that there are 
absolutely no side effects and 

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don't understand when patients 
come back in with all of these, 

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like, adverse reactions, they're
not connecting the dots because,

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Oh my gosh, the pharmaceutical 
company says there's absolutely 

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no side effects. 
What it is, is a once a month 

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injection for arthritis and it's
intended to be received 

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indefinitely, which to me is the
biggest red flag, right? 

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We should never ever, ever 
unless outside of, you know, a 

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type 1 diabetic who literally 
cannot live without insulin. 

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Like, and maybe a couple of 
other cases that I just can't 

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think of off the top of my head.
Like we should not be ever 

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considering a pharmaceutical for
life. 

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Like, that does not make sense. 
It makes sense to their 

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pocketbooks, but it doesn't make
sense to our health or to our 

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pets health. 
And then fortunately and one of 

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the one of the both cool things,
but also really scary things 

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that I learned is that different
countries are getting different 

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package inserts. 
Now, you probably, if you have 

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been offered this for your pet, 
maybe the first time they get 

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it, you're like, Oh my gosh, is 
a miracle, right? 

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But hear me out because there's 
so, so much going on. 

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And at the end of this, the 
while I was preparing for this, 

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the FDA actually issued a 
warning letter to veterinarians 

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on this drug. 
So there is hope that our 

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veterinarians are going to learn
that this is not the miracle 

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that they, they were sold 
basically by the pharmaceutical 

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companies. 
So the reality is there are so 

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many adverse events being 
reported, but what is it first? 

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So it is a genetically 
engineered protein creating 

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created using recombinant DNA 
specific to different things in 

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the body. 
So right now what it is doing is

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attacking or it's binding, 
excuse me, to nerve growth 

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factor and creating biologically
inactive nerve growth factor. 

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And by doing this, it is 
reducing or eliminating the pain

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of arthritis. 
Really interestingly, and I just

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want to throw this in, I was 
listening to Doctor Karen Becker

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and Rodney Habib, who when the 
FDA came out with their warning 

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letter did like a quick, I don't
know like 12 minute video, which

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I wish I could publish for you 
on here, but I, I don't know 

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that I have the rights to do 
that. 

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So what I can do is put the link
in the description or in the 

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show notes. 
So if you want to go watch that 

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you can on I'll put the link to 
Instagram. 

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Thank you. 
But what I heard, one of the 

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things I heard Doctor Karen 
Becker say on this live that was

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so interesting to me, is that 
she has had reports of 

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veterinarians who, because they 
did not do their research and 

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they don't understand what this 
actually is and how this 

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actually works, have been using 
it in place of NSAIDs. 

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So for all kinds of pain, not 
just arthritis. 

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And that is one of the most 
scary things I've heard because 

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it is absolutely not a 
replacement for NSAIDs in any 

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situation. 
It was only designed by the way 

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this medication was originally 
brought for humans and failed. 

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So the FDA said, no, we're not, 
we're not doing this, you can't 

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do this. 
And so they just relabeled it, 

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rebranded it and are giving it 
to pets now. 

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So there are so many side 
effects listed in the package 

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insert, not necessarily in the 
one in the United States. 

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So I think that one, they have 
continually been changing up. 

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But if you go to like the ones 
from Europe from According to 

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Doctor Josie Bug, there are so 
many side effects listed. 

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Increased BUN, lethargy, 
vomiting, anorexia, lameness, 

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cough, bacterial skin 
infections, injection site 

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reaction, UTI's, dermatitis, 
dermal masses, redness, cysts, 

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pain on injection, urinary 
incontinence, increased drinking

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and thirst, ataxia, lack of 
coordination, seizures, 

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anaphylaxis, diarrhea and death.
So in the body, this is a 

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foreign protein. 
So in the body, this is a 

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foreign protein and it is a 
large antibody that creates an 

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antigen, creates a large 
antibody antigen process say 

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that five times fast. 
It is making the nerve growth 

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factor biologically inactive in 
the body. 

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And what? 
But one of the scarier things 

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again in all of these side 
effects that are being seen is 

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that the theory here is that the
only thing nerve growth factor 

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is doing is pain and weakness. 
That's all that it's 

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controlling. 
And so when it inactivates nerve

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growth factor, it's removing the
pain and weakness of arthritis. 

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The reality is nerve growth 
factor does so much more. 

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It help, it regenerates 
everything in the joints and so 

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many things we actually don't 
even know yet that nerve growth 

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factor does. 
We're constantly learning new 

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things that it does. 
And so it's inactivating 

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everything else. 
Especially hate to hear younger 

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animals being given this because
you're inactivating nerve 

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growth, you're you're 
inactivating all of it in the 

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body. 
And we don't have long term 

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studies on it to know if it's 
reversible at this point. 

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So many animals, so many dogs 
and I'm sure cats, but I, I 

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think it is more prevalent in 
dogs right now. 

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But I think by that, I mean I 
think more dogs are receiving 

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Librella and not as many cats 
are receiving Silencia, though I

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don't know, that could be 
changing. 

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It could just be that people are
more aware and paying attention 

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to what's going on with their 
dogs. 

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I think that often is a case 
with our pets. 

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And I've talked about that 
before on the podcast as well. 

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So again, according to Doctor 
Josie, bug nerve growth factor 

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is a peptide. 
We actually know very little 

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about it, but we do know that it
is involved in the maintenance 

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repair and neuroplasticity and 
joints and heart tissue and it 

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does seem to cross the blood 
brain barrier. 

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And so by the way, just a 
reminder Librella Salincia are 

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in activating this. 
So what happens when we 

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introduce these really large 
foreign proteins into the body 

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while we because that's what a 
monoclonal antibody does, it 

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creates immune reactions. 
And so there are four different 

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types, type 1, type 2, type 3 
and type 4 of immune mediated 

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reactions and this one is 
causing problems all over the 

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body. 
She also is very, very clear 

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that comorbidities are not 
studied. 

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So any of the packaging inserts,
even the one in the United 

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States, very clearly says that 
it is only for animals that do 

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not have any other like disease 
processes going on. 

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That's kind of scary because I 
would imagine many of these 

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animals actually do. 
That's the world we live in, 

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right? 
Actually, and I was wrong about 

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Europe having the most extensive
package insert. 

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I wrote this down because it was
important to me. 

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The most thorough package insert
is actually from Canada. 

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The next one is in the UK. 
And then according to Doctor 

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Josie Bug in the United States, 
it pretty much mostly says, we 

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don't know, like they are 
basically passing off, like 

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they'd have no liability. 
It hasn't been studied. 

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We don't know kind of thing in 
the packaging inserts. 

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So what has happened over the 
past almost year is that a group

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of people, including Doctor 
Josie Buke, who I was just 

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talking about and where I've 
learned all of this information 

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from, have been putting 
together, gathering data from 

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people who whose pets have been 
on this medication, who have 

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been given this injection. 
And so the statisticians have 

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gone through, come through all 
of the data. 

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These are the most reported side
effects. 

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Increased thirst, increased 
urination, lack of efficacy, 

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meaning that it doesn't work. 
Lethargy, incontinence, death by

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euthanasia, vomiting, ataxia, 
seizures, anorexia, dogs dying 

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within hours of receiving the 
injection within hours or days, 

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partial or complete paralysis, 
progressing to incontinence, 

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seizures and death, sudden 
blindness, dementia, lupus and 

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other autoimmune conditions. 
So one of the things when I was 

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listening to Doctor Buve on 
Doctor Judy Morgan's, Judy 

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Morgan's podcast, she was saying
our best hope right now is if 

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your pet has received this 
injection, best outcome, the 

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best we can do right now is to 
keep your pet alive for a month 

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for it to wear off in the hopes 
of going back to normal. 

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If your pet has had more than 
one injection, there's a half 

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life calculator on the website, 
which again is pet advocare.com.

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But it's not necessarily the 
same for every pet. 

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It may work once or twice and 
then it may not work anymore. 

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And there are so many serious, 
very serious side effects that 

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it for her. 
And I think for me too, it's 

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just not worth it. 
I mean, of course for you, you 

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have to make that decision for 
your pet. 

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But what I do want to do is say 
that again, the FDA did issue a 

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letter to veterinarians. 
It was on, I want to say 

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December 17th or 18th. 
Actually let me pull it up here,

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I'm sorry, December 16th and it 
says the this is on fda.gov 

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website. 
FDA notifies veterinarians about

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an adverse events reported for 
Librella and here is the letter.

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Dear Veterinarian the US Food 
and Drug Administration's Center

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for Veterinary Medicine has 
completed an evaluation of 

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adverse events reported in dogs 
of various ages treated with 

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Librella. 
The adverse events identified 

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and analyzed include ataxia, 
seizures, other neurologic signs

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including but not limited to 
paresis, recumbency, urinary 

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incontinence, polyuria, and 
polydipsia. 

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In some cases, death, including 
euthanasia, was reported as an 

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outcome of these adverse events.
The FDA is making available 

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reports containing summaries of 
clinical signs reported for 

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Librella in the CVMFOIA FOIA 
electronic reading Room. 

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Drug Information. 
The FDA approved Librella, a 

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monoclonal antibody drug used 
for the control of pain 

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associated with osteoarthritis 
and dogs, on May 5th, 2023, and 

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it was introduced to the 
marketplace later that year. 

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Prior to approval, the FDA 
reviewed available studies and 

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other data on Librella and 
determine Librella to be safe 

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and effective for its intended 
use for control of pain 

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associated with osteoarthritis 
in dogs. 

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Librella is dosed by weight and 
labeled for subcutaneous 

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injection once a month. 
What should a veterinarian do if

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a patient treated with Librella 
has an adverse event? 

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If a dog under your care 
experiences an adverse event 

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while receiving Librella, the 
FDA encourage you, encourages 

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you to report it to Zoetis, the 
drug sponsor, and gives the 

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phone number. 
Drug sponsors are required to 

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submit reports of adverse drug 
events to FDA. 

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If you would prefer to report 
directly to 

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fdapleaseseefda.gov/report 
Animal AE. 

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When reporting adverse events to
the FDA and or Zoetis, please 

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include, if available, a full 
medical history, how many times 

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the dog has received Labella, 
and the lot number on the vial 

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used. 
Where can veterinarians get more

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information about the adverse 
events that have been reported 

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to the FDA? 
The FDA is posting reports 

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00:15:25,960 --> 00:15:28,720
containing adverse drug event 
information for Librella on a 

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rolling basis in the FOIA 
Reading room for CBM. 

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If the agency has additional 
information to share, it will be

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made available additional 
information. 

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The FDA monitors the safety 
profile of all animal drugs 

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after they reach the market, as 
widespread use of a drug in a 

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large number of patients may 
uncover adverse events not 

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observed prior to approval. 
Meaning your pet is the 

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experiment, and I'm not saying 
that they're saying that 

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pharmaceutical companies. 
Drug sponsors are required to 

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report all cases of adverse 
events they receive from the 

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public, including pet owners and
veterinarians, to the FDA. 

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The agency evaluates adverse 
events and other safety 

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information when it becomes 
available and it goes on just a 

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little bit, not much. 
Now, of course, Zoatis has their

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own response and it says we 
continue to have the utmost 

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confidence in the safety and 
efficacy of Librella. 

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Go figure. 
So basically, again, Doctor 

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Josie Bug is the one that I have
been getting so much of this 

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information from and following 
on this issue believe Silencia 

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is the exact same thing for 
cats. 

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I am hoping the FDA also issues 
a warning for Silencia. 

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You can go to petadvocare.com, 
PET advocare.com if you would 

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like to learn more. 
And you know, this is just this 

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is an ongoing thing. 
It's really of course sad to me 

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that our pets are the experiment
most often because this in my 

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opinion, especially knowing that
it was disapproved for humans, 

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00:17:07,359 --> 00:17:10,079
it should never have been 
approved for our pets. 

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The adverse events being listed 
in packaging in other countries 

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and not in the United States is 
terrifying. 

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I think we're seeing so many 
people are waking up to the fact

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that other countries definitely 
have their citizens best 

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interest at heart, more so maybe
not completely more so than 

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agencies in the United States 
do. 

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And we have to be constantly 
looking and researching and 

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doing our own research and 
figuring things out and doing 

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what we feel is best for our 
pets and for ourselves. 

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So with that, I just, you know, 
again, I, I hope to get Doctor 

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00:17:50,120 --> 00:17:52,800
Josie Beau back on to talk about
this some more. 

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As she said, the best we can 
hope for right now. 

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If your pet has received an 
injection of Librella or 

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Silencia, keep them alive for 
the month so that it has time to

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wear off. 
And we cross all of our fingers 

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and toes and hope that the pet 
does get back to normal. 

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Unfortunately, that's not what 
she and other people in the 

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00:18:17,960 --> 00:18:22,440
field are seeing with this 
particular pharmaceutical. 

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So yeah, there's that. 
There's so many other things 

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that we can do in relation to 
arthritis and osteoarthritis, 

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namely some of the things that I
would start with. 

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Of course, when I work with a 
client one-on-one, I am always 

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00:18:39,840 --> 00:18:42,840
looking for, you know, I'm 
looking at that individual's 

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symptoms and needs. 
And so it can vary, but I'm 

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always looking to create an 
anti-inflammatory diet. 

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00:18:51,520 --> 00:18:57,280
I am using very strategic 
supplementation, high doses of 

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Omega threes again for 
anti-inflammatory properties, 

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00:19:00,680 --> 00:19:02,880
potentially like to mark 
curcumin. 

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00:19:02,920 --> 00:19:07,240
Full spectrum hemp extracts are 
amazing for helping manage pain,

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00:19:07,240 --> 00:19:11,920
medicinal mushrooms for both for
inflammation and for overall 

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immune support. 
Because what we really need to 

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00:19:14,440 --> 00:19:18,880
do is support the body and not 
attack the symptoms. 

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00:19:18,880 --> 00:19:21,880
And I, I know I say this all the
time and maybe I sound like a 

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00:19:21,880 --> 00:19:25,520
broken record, but that is 
always the case. 

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00:19:25,720 --> 00:19:29,680
Supporting the body, supporting 
the immune system, providing an 

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00:19:29,680 --> 00:19:33,680
anti-inflammatory body, creating
an environment that is 

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00:19:33,680 --> 00:19:37,120
anti-inflammatory, creating a 
diet that is anti-inflammatory. 

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00:19:37,120 --> 00:19:40,520
That is going to be some of the 
best things we can do. 

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00:19:40,520 --> 00:19:43,800
And then we can also look at 
other modalities like pulsed 

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00:19:43,800 --> 00:19:47,280
electromagnetic frequency, 
acupressure, acupuncture, There 

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00:19:47,280 --> 00:19:49,800
are lots of other modalities 
that we can look at that are 

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00:19:49,800 --> 00:19:54,520
very beneficial for pain. 
So with that, now if you do have

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00:19:54,520 --> 00:19:56,680
any questions, please feel free 
to reach out to me. 

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00:19:56,680 --> 00:19:58,680
And Instagram is usually the 
best place to do that. 

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00:19:58,680 --> 00:20:03,000
And I sincerely want to give 
like my deepest sympathy to 

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00:20:03,080 --> 00:20:06,880
anyone who trusted their 
veterinarian to give this 

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00:20:06,880 --> 00:20:10,400
pharmaceutical to their pet and 
their pet has suffered because 

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00:20:10,400 --> 00:20:11,520
of it. 
It breaks my heart. 

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00:20:11,520 --> 00:20:14,640
So with that, I will talk to you
guys next week. 

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00:20:14,800 --> 00:20:17,840
I have a guest next week. 
It's a very, very fun and 

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00:20:17,840 --> 00:20:21,160
exciting episode. 
I I please please, please don't 

331
00:20:21,160 --> 00:20:22,720
miss it. 
You're going to want to catch it

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00:20:22,800 --> 00:20:27,360
right away as soon as it airs. 
It is very time, like very much 

333
00:20:27,360 --> 00:20:30,160
the day it airs. 
It is about that day. 

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00:20:30,480 --> 00:20:34,280
So please set your reminders for
January 7th. 

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00:20:34,280 --> 00:20:38,680
And that episode is with Amanda 
Wilborn of The Nautical Dog, and

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00:20:38,680 --> 00:20:40,840
I cannot wait for you to hear 
it. 

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00:20:41,080 --> 00:20:44,640
So with that, I hope you and 
your fur babies had a wonderful 

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00:20:44,800 --> 00:20:47,280
holiday and I will talk to you 
next.